Abstract: In one aspect, the invention relates to bicyclic MGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention provides methods of detecting triple negative breast cancer recurrence using biomarkers.

Abstract: In one aspect, the invention relates to compounds, including phenylethynylbenzamide derivatives, cycloalkylethynylbenzamide derivatives, styrylbenzamide derivatives, 4-(3-phenyl-1,2,4-oxadiazol-5-yl)benzamide derivatives, 4-(pyridinylethynyl)benzamide derivatives, and N1-phenylterephthalamide derivatives, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Disclosed is an underwater vehicle that can be operated as a remotely operated vehicle (ROV) or as an autonomous vehicle (AUV). The underwater vehicle has a tether, which may be a fiberoptic cable, that connects the vehicle to a control console. The underwater vehicle has vertical and lateral thrusters, pitch and yaw control fins, and a propulsor, all of which may be used in an ROV-mode when the underwater vehicle is operating at slow speeds. The underwater vehicle may also be operated in a AUV-mode when operating at higher speeds. The operator may switch the vehicle between ROV-mode and AUV-mode. The underwater vehicle also has a fail-safe mode, in which the vehicle may navigate according to a pre-loaded mission plan if the tether is severed.

Abstract: Automatic energy management is provided, in even the most complex multi-building system. The necessity of a human operator for managing energy in a complex, multi-building system is reduced and even eliminated. Computer-based monitoring and computer-based recognition of adverse energy events (such as the approach of a new energy peak) is highly advantageous in energy management. Immediate automatic querying of energy users within a system of buildings for energy curtailment possibilities is provided. Such immediate, automatic querying may be answered by the energy users through artificial intelligence and/or neural network technology provided to or programmed into the energy users, and the queried energy users may respond in real-time. Those real-time computerized responses with energy curtailment possibilities may be received automatically by a data processing facility, and processed in real-time.

Abstract: Automatic energy management is provided, in even the most complex multi-building system. The necessity of a human operator for managing energy in a complex, multi-building system is reduced and even eliminated. Computer-based monitoring and computer-based recognition of adverse energy events (such as the approach of a new energy peak) is highly advantageous in energy management. Immediate automatic querying of energy users within a system of buildings for energy curtailment possibilities is provided. Such immediate, automatic querying may be answered by the energy users through artificial intelligence and/or neural network technology provided to or programmed into the energy users, and the queried energy users may respond in real-time. Those real-time computerized responses with energy curtailment possibilities may be received automatically by a data processing facility, and processed in real-time.

Abstract: A tool to assess risks associated with software applications, and controls implemented to mitigate these risks, includes a first software component configured to gather information about the risks and controls, and a second software component configured to display the gathered information. The first software component includes a self-assessment tool which is invoked by a user to enter information reflective of risk levels over a number of risk categories. These risk levels are used to calculate a risk score associated with a particular application. The user also enters information as to whether or not a number of specific control attributes have been implemented, and this information is used to calculate a control score. This process may be repeated for each of several software applications.

Abstract: A method of automatically conducting patch clamp testing is provided wherein a liquid interface is utilized. The liquid interface is defined in a liquid suspension between layers of distinct densities such that cells introduced into the liquid suspension float towards the interface. Thus, the cells are locatable relative to the interface.

Abstract: The present application is directed to pipette configurations, arrays of the same and methods for using such pipettes and arrays to accomplish electrical measurements, including whole cell and on cell measurements. In one aspect of the present invention, a pipette includes a hollow tubular section having a distal portion and a tip portion. A bubble is formed at the tip and includes an interior chamber in communication with the hollow tubular section at an end adjacent to the bubble portion. The bubble may have a diameter greater than the diameter of an adjacent portion of the hollow tubular section. An aperture is formed between the internal chamber and an exterior surface of the bubble to accommodate seal formation.

Abstract: The present invention is directed to a rapid, quantitative screening procedure of ?-aminobutyric acid (GABA)-mediated halide transport in cells with the use of a conventional 384-well fluorescence plate reader (FLIPR). The halide sensor is a novel yellow fluorescent protein (YFP) with mutations at positions 46/148/152 that exhibits bright fluorescence at 37° C.

Abstract: A dishwasher incorporates a primary filter cleaning system for removing food debris from circulated wash water. The dishwasher having a sump formed in the bottom and a wash pump having an inlet in communication with the sump. A collection chamber is formed through the bottom of the sump and a filter is situated over the top of the sump. The filter has an opening for depositing debris in the collection chamber. A stationary manifold is situated about the upper periphery of the sump and is aligned with the discharge of the pump. The manifold has multiple spaced spray nozzles, with each of the nozzles being aligned for spray contact with the filter. When water is pumped from the sump to the manifold, the water is sprayed across the filter to remove any food debris on the filter. The debris is then swept into the collection chamber.

Abstract: A dishwasher incorporates a primary filter cleaning system for removing food debris from circulated wash water. The dishwasher having a sump formed in the floor of the dishwasher and a wash pump having an inlet in communication with the sump. A collection chamber is formed in the bottom of the sump and comprises at least one wall having filter media. A sprayer is disposed within the collection chamber and is in fluid communication with the pump. The sprayer has at least one nozzle aligned for spray contact with the filter media. When water is pumped from the sump to sprayer, the water is sprayed across the filter media to remove any debris from the filter media.

Abstract: A pump priming sensing system for managing a filtration system is provided. The sensing system is capable of monitoring the state of the motor that operates the pump in a dishwasher to determine if the pump is receiving enough water to operate at a normal torque level. A filter is provided above the pump inlet to the pump. When a mixture of water and air is received through the pump inlet, the torque level falls. The motor transmits this decrease in torque level to a controller, which activates a filter cleaning system to clean the filter of soil/food/debris loosed from the dishes being cleaned in the dishwasher. Once the filter has been cleaned, normal operation of the dishwasher is resumed with the pump operating at a normal torque level.

Abstract: A fill level control system for an article cleaning apparatus is provided. The fill level control system uses a sensor array to monitor a plurality of fill level points within, for example, a dishwasher. The level of water for each wash phase is monitored as a function of its height above the sump of an article cleaning apparatus, and the liquid used in the washing apparatus is introduced as a function of signals produced giving the level of liquid. The fill level control system further includes a low level sensor that turns the pumping system for the article cleaning apparatus off when the sump portion has been completely emptied. A further aspect of the fill level control system is an optional temperature control sensor, integrated with the liquid level sensors, to provide signals for modifying the temperature within the article cleaning apparatus.

Abstract: A dishwasher incorporating a food waste disposal system and has a sump formed in its lower portion and a drain pump located in the sump is provided. The drain pump includes a motor driving an impeller and a chopping blade. A fine filter is positioned before the inlet portion of a wash pump in the sump to collect and concentrate food particles held adjacent the drain pump. An electronic controller, which controls the dishwasher cycle and the wash and drain pumps, causes the chopping blade to rotate and chop any food particles held adjacent the drain pump. An electrically controlled valve, operated by the electronic controller, is in the drain line of the drain pump and can be pulsed on and off during operation of the dishwasher to allow removal of some food particles in the wash water at any intermediate point of the cycle.

Abstract: A method and system for dynamically controlling operation of a dishwasher during a cleaning cycle. The method includes detecting a plurality of conditions in the dishwasher during operation, evaluating the plurality of detected conditions to determine a dynamic control response, and sending a signal representing the dynamic control response to at least one component of the dishwasher. The plurality of detected conditions can include some or all of a rate of change of a wash water temperature, an approximate surface area and thermal mass of a plurality of dishes loaded in the dishwasher, an amount of wash water added to the dishwasher and a status of a full flow filter. The control system includes means for detecting a plurality of conditions in the dishwasher during operation, means for evaluating the plurality of detected conditions to determine a dynamic control response, and means for sending a signal representing the dynamic control response to control at least one component of the dishwasher.

Abstract: A dishwasher with a novel drying cycle is provided. The dishwasher door includes a vent channel connecting the interior of the dishwasher to the outside and housing a condenser section that condenses water vapor from moisture laden air from the interior of the dishwasher and directs the condensed water back into the dishwasher. A vent valve covers the opening of the vent channel into the dishwasher and is opened and closed at appropriate times during the drying cycle. A heater adjacent a blower heats air entering the dishwasher. A temperature sensor in the dishwasher interior provides temperature measurements of the inside of the dishwasher that may be used to control the duration of the drying cycle. A controller interconnects the operating components of the dishwasher and provides the logic for the drying cycle.

Abstract: A dishwasher having an adjustable article rack is provided. The dishwasher includes a pair of horizontal slide assemblies attached to opposed sidewalls and a fixed vertically extending member is attached to each slide assembly. A vertically moveable member is attached to each fixed member, the vertically movable member of the fixed member cooperating to form a self-correcting ratchet mechanism. A rack for holding articles is attached to the vertically movable members, allowing the rack to be vertically adjusted as the movable member moves with respect to the fixed member.

Abstract: The present invention is directed to methods and compositions for evaluating allelic variations with improved quality controls, methods of preparing such compositions, and applications employing such compositions and methods. In particular, the present invention provides methods and compositions for reducing false positives and/or false negatives in nucleic acid measurements.

Abstract: The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.