Patents by Inventor David Wen
David Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9634654Abstract: A clock driver control scheme for a resonant clock distribution network provides robust operation by controlling a pulse width of the output of clock driver circuits that drive the resonant clock distribution network so that changes are sequenced. The clock driver control circuit controls the clock driver circuits in the corresponding sector according to a selected operating mode via a plurality of control signals provided to corresponding clock driver circuits. The pulse widths differ for at least some of the sectors during operation of digital circuits within the integrated circuit having clock inputs coupled to the resonant clock distribution network. The different pulse widths may be a transient difference that is imposed in response to a mode or frequency change of the global clock that provides an input to the clock driver circuits.Type: GrantFiled: August 7, 2015Date of Patent: April 25, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Thomas J. Bucelot, Phillip J. Restle, David Wen-Hao Shan
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Patent number: 9618966Abstract: A pulse-drive resonant clock with on-the fly mode changing provides robust operation in a resonant clock distribution network, in particular for processor circuits having a dynamically-varied operating frequency. The clock drivers for the resonant clock distribution network include a pulse width control circuit having selectable operating modes corresponding to multiple clocking modes of the resonant clock distribution network. The pulse width control circuit includes a delay line that has a selectable delay length to provide pulse enable signals that control the pulse widths of the clock drivers in a sector of the resonant clock distribution network. The delay line responds to a mode control signal so that at least one pulse width of the output is changed from a first pulse width to a second pulse width without generating half-cycles with a pulse width narrower than the first or second pulse width.Type: GrantFiled: August 18, 2015Date of Patent: April 11, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Thomas J. Bucelot, Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan, Christos Vezyrtzis
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Patent number: 9612614Abstract: A pulse-drive resonant clock with on-the fly mode changing provides robust operation in a resonant clock distribution network, in particular for processor circuits having a dynamically-varied operating frequency. The clock drivers for the resonant clock distribution network include a pulse width control circuit having selectable operating modes corresponding to multiple clocking modes of the resonant clock distribution network. The pulse width control circuit includes a delay line that has a selectable delay length to provide pulse enable signals that control the pulse widths of the clock drivers in a sector of the resonant clock distribution network. The delay line responds to a mode control signal so that at least one pulse width of the output is changed from a first pulse width to a second pulse width without generating half-cycles with a pulse width narrower than the first or second pulse width.Type: GrantFiled: July 31, 2015Date of Patent: April 4, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Thomas J. Bucelot, Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan, Christos Vezyrtzis
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Patent number: 9575119Abstract: A delay measurement technique using a tapped delay line edge capture circuit that captures tap position of edges within the delay line provides accuracy of measurement to one pico-second and below. A control circuit causes latches to capture an edge of a signal delayed through the delay line at taps of the delay line. The frequency of a clock from which the signal is derived is adjusted and tap outputs are captured by latches and averaged. A first frequency is found at which the average edge position is midway between two adjacent tap positions. A second signal, which may be the reference signal that clocks the latches, is propagated through the delay line and a second frequency is found for which the average edge position lies at the boundary between the two tap positions. The delay is determined from the difference between the periods of the first frequency and the second frequency.Type: GrantFiled: February 10, 2016Date of Patent: February 21, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan
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Patent number: 9568548Abstract: A delay measurement technique using a tapped delay line edge capture circuit that captures tap position of edges within the delay line provides accuracy of measurement to one pico-second and below. A control circuit causes latches to capture an edge of a signal delayed through the delay line at taps of the delay line. The frequency of a clock from which the signal is derived is adjusted and tap outputs are captured by latches and averaged. A first frequency is found at which the average edge position is midway between two adjacent tap positions. A second signal, which may be the reference signal that clocks the latches, is propagated through the delay line and a second frequency is found for which the average edge position lies at the boundary between the two tap positions. The delay is determined from the difference between the periods of the first frequency and the second frequency.Type: GrantFiled: October 14, 2015Date of Patent: February 14, 2017Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan
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Publication number: 20170040981Abstract: A clock driver control scheme for a resonant clock distribution network provides robust operation by controlling a pulse width of the output of clock driver circuits that drive the resonant clock distribution network so that changes are sequenced. The clock driver control circuit controls the clock driver circuits in the corresponding sector according to a selected operating mode via a plurality of control signals provided to corresponding clock driver circuits. The pulse widths differ for at least some of the sectors during operation of digital circuits within the integrated circuit having clock inputs coupled to the resonant clock distribution network. The different pulse widths may be a transient difference that is imposed in response to a mode or frequency change of the global clock that provides an input to the clock driver circuits.Type: ApplicationFiled: August 18, 2015Publication date: February 9, 2017Inventors: Thomas J. Bucelot, Phillip J. Restle, David Wen-Hao Shan
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Publication number: 20170040987Abstract: A clock driver control scheme for a resonant clock distribution network provides robust operation by controlling a pulse width of the output of clock driver circuits that drive the resonant clock distribution network so that changes are sequenced. The clock driver control circuit controls the clock driver circuits in the corresponding sector according to a selected operating mode via a plurality of control signals provided to corresponding clock driver circuits. The pulse widths differ for at least some of the sectors during operation of digital circuits within the integrated circuit having clock inputs coupled to the resonant clock distribution network. The different pulse widths may be a transient difference that is imposed in response to a mode or frequency change of the global clock that provides an input to the clock driver circuits.Type: ApplicationFiled: August 7, 2015Publication date: February 9, 2017Inventors: Thomas J. Bucelot, Phillip J. Restle, David Wen-Hao Shan
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Publication number: 20170031384Abstract: A pulse-drive resonant clock with on-the fly mode changing provides robust operation in a resonant clock distribution network, in particular for processor circuits having a dynamically-varied operating frequency. The clock drivers for the resonant clock distribution network include a pulse width control circuit having selectable operating modes corresponding to multiple clocking modes of the resonant clock distribution network. The pulse width control circuit includes a delay line that has a selectable delay length to provide pulse enable signals that control the pulse widths of the clock drivers in a sector of the resonant clock distribution network. The delay line responds to a mode control signal so that at least one pulse width of the output is changed from a first pulse width to a second pulse width without generating half-cycles with a pulse width narrower than the first or second pulse width.Type: ApplicationFiled: August 18, 2015Publication date: February 2, 2017Inventors: Thomas J. Bucelot, Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan, Christos Vezyrtzis
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Publication number: 20170031383Abstract: A pulse-drive resonant clock with on-the fly mode changing provides robust operation in a resonant clock distribution network, in particular for processor circuits having a dynamically-varied operating frequency. The clock drivers for the resonant clock distribution network include a pulse width control circuit having selectable operating modes corresponding to multiple clocking modes of the resonant clock distribution network. The pulse width control circuit includes a delay line that has a selectable delay length to provide pulse enable signals that control the pulse widths of the clock drivers in a sector of the resonant clock distribution network. The delay line responds to a mode control signal so that at least one pulse width of the output is changed from a first pulse width to a second pulse width without generating half-cycles with a pulse width narrower than the first or second pulse width.Type: ApplicationFiled: July 31, 2015Publication date: February 2, 2017Inventors: Thomas J. Bucelot, Robert L. Franch, Phillip J. Restle, David Wen-Hao Shan, Christos Vezyrtzis
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Patent number: 9512080Abstract: A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.Type: GrantFiled: July 10, 2013Date of Patent: December 6, 2016Assignee: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Anand Natrajan, David Wen
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Patent number: 9487480Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.Type: GrantFiled: May 18, 2011Date of Patent: November 8, 2016Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
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Publication number: 20160274094Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.Type: ApplicationFiled: May 28, 2016Publication date: September 22, 2016Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
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Patent number: 9353056Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.Type: GrantFiled: May 18, 2011Date of Patent: May 31, 2016Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
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Publication number: 20160131588Abstract: The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.Type: ApplicationFiled: May 13, 2014Publication date: May 12, 2016Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Wen
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Publication number: 20150197491Abstract: A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.Type: ApplicationFiled: July 10, 2013Publication date: July 16, 2015Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Wen
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Patent number: 8863066Abstract: High performance clock distributions and similar wiring networks require improvements in reliability and performance. This is especially true when hierarchical wiring with different metal thicknesses is employed and when a smaller number of large, higher-power buffers are used to reduce timing variability. Routing of critical nets improves robustness, reliability, and resistance while minimizing track and power usage. The method further optimizes the use of multiple physical pins on buffers to achieve desired electrical criteria. This involves optimal selection of additional routing beyond what is needed to satisfy simple connectivity. The routing involves an iterative process to select and evaluate additional possible routes on multiple layers. Each iteration involves extraction and simulation or estimation, and additional routes are added until the desired electrical criteria are met.Type: GrantFiled: May 15, 2013Date of Patent: October 14, 2014Assignee: International Business Machines CorporationInventors: Joseph N. Kozhaya, Phillip J. Restle, David Wen-Hao Shan
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Publication number: 20130065325Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.Type: ApplicationFiled: May 18, 2011Publication date: March 14, 2013Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
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Patent number: 8293908Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.Type: GrantFiled: November 18, 2008Date of Patent: October 23, 2012Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Wen
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Publication number: 20120114796Abstract: A method of manufacturing a porous vegetable filler for use in a foaming process mainly comprises exposing discarded coffee grounds to sunlight to a moisture content of 5%-15%; then baking the coffee grounds after solarization using a dryer at 120° C.-350° C. for 1 to 4 hours; finally grinding the baked coffee grounds to a size of less than 1000 mesh to obtain a porous vegetable filler for use in a foaming process.Type: ApplicationFiled: November 8, 2010Publication date: May 10, 2012Inventors: Chi-Feng Lai, Yun-Tong Ou, David Wen
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Publication number: 20100256380Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3-propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.Type: ApplicationFiled: November 18, 2008Publication date: October 7, 2010Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Anand Natrajan, David Wen