Patents by Inventor David Wen

David Wen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160131588
    Abstract: The present invention relates to methods of enhancing chemiluminescence from a chemiluminescent label comprising contacting a chemiluminescent label with an acid in the presence of a degradable cationic surfactant and hydrogen peroxide followed by the addition of a base. Related kits containing such degradable cationic surfactant are also provided. The degradable cationic surfactant can compress light emission time of the chemiluminescent label to an extent that is comparable to or shorter than conventional surfactants. The degradable cationic surfactant can also increase chemiluminescence of the chemiluminescent label, providing increased light emission output that is comparable to conventional surfactants.
    Type: Application
    Filed: May 13, 2014
    Publication date: May 12, 2016
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • Publication number: 20150197491
    Abstract: A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.
    Type: Application
    Filed: July 10, 2013
    Publication date: July 16, 2015
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • Patent number: 8863066
    Abstract: High performance clock distributions and similar wiring networks require improvements in reliability and performance. This is especially true when hierarchical wiring with different metal thicknesses is employed and when a smaller number of large, higher-power buffers are used to reduce timing variability. Routing of critical nets improves robustness, reliability, and resistance while minimizing track and power usage. The method further optimizes the use of multiple physical pins on buffers to achieve desired electrical criteria. This involves optimal selection of additional routing beyond what is needed to satisfy simple connectivity. The routing involves an iterative process to select and evaluate additional possible routes on multiple layers. Each iteration involves extraction and simulation or estimation, and additional routes are added until the desired electrical criteria are met.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: October 14, 2014
    Assignee: International Business Machines Corporation
    Inventors: Joseph N. Kozhaya, Phillip J. Restle, David Wen-Hao Shan
  • Publication number: 20130065325
    Abstract: Zwitterion-containing compounds for the modification of hydrophobic molecules to improve their solubility and/or to lower their non-specific binding as provided. The zwitterion-containing compounds may be suitable for modification of detectable labels such as biotin and fluorescein to improve their solubility. The zwitterion-containing compounds may also be useful for the preparation of conjugates of proteins, peptides and other macromolecules or for crosslinking molecules and/or macromolecules.
    Type: Application
    Filed: May 18, 2011
    Publication date: March 14, 2013
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: Anand Natrajan, David Sharpe, David Wen, Qingping Jiang
  • Patent number: 8293908
    Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: October 23, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • Publication number: 20120114796
    Abstract: A method of manufacturing a porous vegetable filler for use in a foaming process mainly comprises exposing discarded coffee grounds to sunlight to a moisture content of 5%-15%; then baking the coffee grounds after solarization using a dryer at 120° C.-350° C. for 1 to 4 hours; finally grinding the baked coffee grounds to a size of less than 1000 mesh to obtain a porous vegetable filler for use in a foaming process.
    Type: Application
    Filed: November 8, 2010
    Publication date: May 10, 2012
    Inventors: Chi-Feng Lai, Yun-Tong Ou, David Wen
  • Publication number: 20100256380
    Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3-propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.
    Type: Application
    Filed: November 18, 2008
    Publication date: October 7, 2010
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • Publication number: 20070015301
    Abstract: A light sensor having a light conversion element between first and second electrodes is disclosed. The light conversion element includes a body of semiconductor material having first and second surfaces. The body of semiconductor material is of a first conductivity type and has doping elements in a concentration gradient that creates a first electrostatic field having a magnitude that varies monotonically from the first surface to the second surface. A bias circuit applies a variable potential between the first and second electrodes to create a second electrostatic field having a direction opposite to that of the first electrostatic field and a magnitude determined by the potential. One of the electrodes is transparent to light in a predetermined band of wavelengths. The body of semiconductor material can include an epitaxial body having a monotonically increasing concentration of a doping element as a function of the distance from one the surfaces.
    Type: Application
    Filed: July 14, 2005
    Publication date: January 18, 2007
    Inventors: David Wen, Xinqiao Liu, Ahn Vu, Steven Onishi
  • Publication number: 20060033826
    Abstract: The present invention includes an imaging apparatus having an imaging array, readout amplifier, and controller. The imaging array includes a plurality of pixels that accumulate charge when exposed to light. The readout amplifier receives charge from the pixels and generates a pixel signal indicative of the amount of charge received. The controller causes the charge from a plurality of the pixels to be added together to form a sum charge that is received by the readout amplifier. The imaging array can include a plurality of columns of pixels, and the controller causes the charge from a plurality of pixels in one of the columns to be added together to form a partial sum charge that is included in the sum charge. The readout amplifier can include a horizontal shift register, and the partial sum charge can be generated in the shift cells.
    Type: Application
    Filed: August 12, 2004
    Publication date: February 16, 2006
    Inventors: Xinqiao Liu, David Wen, Anh Vu, Steven Onishi, Charles Arduini
  • Publication number: 20050275906
    Abstract: Embodiments of the present invention are directed to an apparatus and a method for synchronizing the velocity of an image of a moving object or target and the clocking of image sensor elements used to track the moving target.
    Type: Application
    Filed: August 18, 2005
    Publication date: December 15, 2005
    Applicant: Fairchild Imaging
    Inventor: David Wen
  • Publication number: 20050274873
    Abstract: An imaging array having a CCD imaging array that includes a plurality of pixels that accumulate charge when exposed to light and a readout amplifier is disclosed. The readout amplifier includes an operational amplifier having an input and an output port and a feedback capacitor connecting the input and output ports and a variable impedance path between the input and output ports, the path having an impedance controlled by a reset signal. A reset signal generator generates the reset signal in three sequential phases in which the path between the input and output ports has three impedance values to provide a starting voltage at the amplifier input prior to the measurement of charge from each pixel that has reduced noise.
    Type: Application
    Filed: June 10, 2004
    Publication date: December 15, 2005
    Inventors: Xinqiao Liu, David Wen, Anh Vu, Steven Onishi, Charles Arduini
  • Patent number: 6933975
    Abstract: An apparatus and a method for synchronizing the velocity of an image of a moving object and the clocking of image sensor elements used to track the moving target. The imaging apparatus includes a two-dimensional array of image sensor elements being configured to sense a first set of image elements in a first direction according to a clock rate. A plurality of rows of image sensor elements are spaced from each other. The rows of image sensor elements are configured to sense a second set of image elements of the target moving in the first direction according to the clock rate. Each row has image sensor elements that are different in length from the image sensor elements of the other rows. A measurement module is coupled with the plurality of rows of image sensor elements to measure the sharpness of detected image elements and to identify the row of image sensor elements having the sharpest detected image elements.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: August 23, 2005
    Assignee: Fairchild Imaging
    Inventor: David Wen
  • Patent number: 6861464
    Abstract: A two component, curable hot melt adhesive system includes a first hot melt adhesive formulation which has a softening temperature greater than room temperature and which includes a first component of a curable adhesive therein. The system includes a second hot melt adhesive formulation which has a softening temperature which is greater than room temperature and which includes a second component of a curable adhesive therein. The second component is reactive with the first component to provide a cured adhesive bond. In use, the two formulations are heated to a temperature above their softening temperature and are contacted so as to cause mixing. The mixture cools to provide a thermoplastic bond which subsequently cures to provide a permanent adhesive bond. While the first and the second component individually perform as hot melt adhesives, combining the first and the second gives enhanced adhesive performance in extended temperature ranges.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: March 1, 2005
    Assignee: Diversified Chemical Technologies, Inc.
    Inventors: Rajan Eadara, Mooil Chung, David Wen-Lung Chang, Sunny K. George, Patrick A. Ohaka, Joribeth E. Joseff, Yushin Ahn
  • Patent number: 6841811
    Abstract: Large area, fast frame rate, charge coupled devices (CCDs) are provided. Interline transfer CCDs can have interleaved pinned photodiodes and vertical shift registers. The interline transfer CCDs are ideal for producing high frame rate video images from a continuous light source. The photodiodes transfer charge indicative of the previous video frame to an adjacent vertical shift register with little or no lag, while light from the current video frame is integrating in the photodiodes. The charge signals only have to travel a short distance from a photodiode to an adjacent vertical shift register. The charge signals indicative of each video frame are then shifted out of the vertical shift registers. Each vertical shift register has a doping gradient that increases the charge transfer rate. All of these factors provide a fast and efficient video frame rate, even in a large area CCD.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: January 11, 2005
    Assignee: Fairchild Imaging
    Inventors: David Wen, Steve Onishi
  • Patent number: 6818483
    Abstract: Large area, fast frame rate, charge coupled devices (CCDs) are provided. Interline transfer CCDs can have interleaved pinned photodiodes and vertical shift registers. The interline transfer CCDs are ideal for producing high frame rate video images from a continuous light source. The photodiodes transfer charge indicative of the previous video frame to an adjacent vertical shift register with little or no lag, while light from the current video frame is integrating in the photodiodes. The charge signals only have to travel a short distance from a photodiode to an adjacent vertical shift register. The charge signals indicative of each video frame are then shifted out of the vertical shift registers. Each vertical shift register has a doping gradient that increases the charge transfer rate. All of these factors provide a fast and efficient video frame rate, even in a large area CCD.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: November 16, 2004
    Assignee: Fairchild Imaging
    Inventors: David Wen, Steve Onishi
  • Publication number: 20040135914
    Abstract: Embodiments of the present invention are directed to an apparatus and a method for synchronizing the velocity of an image of a moving object or target and the clocking of image sensor elements used to track the moving target. In one embodiment, an imaging apparatus comprises a two-dimensional array of image sensor elements being configured to sense a first set of image elements of a target moving in a first direction with respect to the two-dimensional array of image sensor elements, to integrate light from the set of image elements into corresponding pixel values, and to shift the pixel values along the image sensor elements in the first direction according to a clock rate. A plurality of rows of image sensor elements are spaced from each other and extend in the first direction.
    Type: Application
    Filed: April 26, 2002
    Publication date: July 15, 2004
    Applicant: Fairchild Imaging
    Inventor: David Wen
  • Publication number: 20040033656
    Abstract: Large area, fast frame rate, charge coupled devices (CCDs) are provided. Interline transfer CCDs can have interleaved pinned photodiodes and vertical shift registers. The interline transfer CCDs are ideal for producing high frame rate video images from a continuous light source. The photodiodes transfer charge indicative of the previous video frame to an adjacent vertical shift register with little or no lag, while light from the current video frame is integrating in the photodiodes. The charge signals only have to travel a short distance from a photodiode to an adjacent vertical shift register. The charge signals indicative of each video frame are then shifted out of the vertical shift registers. Each vertical shift register has a doping gradient that increases the charge transfer rate. All of these factors provide a fast and efficient video frame rate, even in a large area CCD.
    Type: Application
    Filed: August 14, 2003
    Publication date: February 19, 2004
    Applicant: Fairchild Imaging
    Inventors: David Wen, Steve Onishi
  • Publication number: 20040014332
    Abstract: Large area, fast frame rate, charge coupled devices (CCDs) are provided. Interline transfer CCDs can have interleaved pinned photodiodes and vertical shift registers. The interline transfer CCDs are ideal for producing high frame rate video images from a continuous light source. The photodiodes transfer charge indicative of the previous video frame to an adjacent vertical shift register with little or no lag, while light from the current video frame is integrating in the photodiodes. The charge signals only have to travel a short distance from a photodiode to an adjacent vertical shift register. The charge signals indicative of each video frame are then shifted out of the vertical shift registers. Each vertical shift register has a doping gradient that increases the charge transfer rate. All of these factors provide a fast and efficient video frame rate, even in a large area CCD.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 22, 2004
    Applicant: Fairchild Imaging
    Inventors: David Wen, Steve Onishi
  • Publication number: 20040012688
    Abstract: Large area cameras that sense light using charge coupled devices are provided. The large area cameras have a scintillator that senses short wavelength (e.g. x-rays) radiation and provides light at a longer wavelength. Optical fibers transmit the light to charge coupled devices arranged in an M×N array. Subsets of the image signals can be summed together to increase signal strength and frame rate. The image signals can be amplified and digitized to accomplish image reconstruction in near-real time for a plurality of CCDs. To accomplish image reconstruction in near-real time for a plurality of CCDs, the digitized signals for one image frame are stored in first memory circuits, while image signals from another frame are read out of second memory circuits. The image signal are written into and read out of the memory circuits in configurations that are independent of the orientation of the CCDs within the CCD array.
    Type: Application
    Filed: July 16, 2002
    Publication date: January 22, 2004
    Applicant: Fairchild Imaging
    Inventors: Natale F. Tinnerino, David Wen, Edward Leon Guerrero, Douglas Debs, Dan Laxson
  • Publication number: 20040014866
    Abstract: A two component, curable hot melt adhesive system includes a first hot melt adhesive formulation which has a softening temperature greater than room temperature and which includes a first component of a curable adhesive therein. The system includes a second hot melt adhesive formulation which has a softening temperature which is greater than room temperature and which includes a second component of a curable adhesive therein. The second component is reactive with the first component to provide a cured adhesive bond. In use, the two formulations are heated to a temperature above their softening temperature and are contacted so as to cause mixing. The mixture cools to provide a thermoplastic bond which subsequently cures to provide a permanent adhesive bond. While the first and the second component individually perform as hot melt adhesives, combining the first and the second gives enhanced adhesive performance in extended temperature ranges.
    Type: Application
    Filed: July 19, 2002
    Publication date: January 22, 2004
    Inventors: Rajan Eadara, Mooil Chung, David Wen-Lung Chang, Sunny K. George, Patrick A. Ohaka, Joribeth E. Joseff, Yushin Ahn