Abstract: A high energy explosive having reduced shock sensitivity for tactical weapon platforms to increase the safety margins to the warfighter if the weapon became involved in an unplanned event on the battlefield. The high energy explosive having a reduced crystalline particle size below about 30 microns, preferably 10 microns, and coated with a thermoplastic elastomer, which is capable of being compressed into a warhead configuration and attached to a weapon. The high energy explosive having a greater than 25% reduction in shock sensitivity compared to the same crystalline energetic material without undergoing size reduction prior to being coated.

Abstract: A box closure device having a first piece, a second piece, and a hub separating the first piece and second piece is provided. The first piece can have one or more engagement portions. The second piece can extend in both directions relative to the hub and is spaced from the first piece a selected amount allowing for box flaps to fit between the top piece and bottom piece. The second piece can have a blade to assist in positioning the closure device between the interior ends of two flaps. The second piece can also have a glide. In use, the user or a machine can engage the engagement portion(s) and twist the closure device so that the bottom piece is no longer aligned with a gap between the flaps thereby locking the flaps in a closed position. Lobes can be located on the ends of the second piece.

Abstract: The present invention relates to pharmaceutical compositions suitable for oral administration, and more particularly to pharmaceutical compositions, including pharmaceutical tablet compositions, containing N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide (“AZD9291”) or a pharmaceutically acceptable salt thereof, wherein such compositions comprise a certain amount of microcrystalline cellulose and at least one other pharmaceutical diluent.

Abstract: Cationic polymers having one or more anionic ligand end groups, including a new class of carboxylated branched poly(beta-amino ester)s that can self-assemble into nanoparticles for efficient intracellular delivery of different biomolecules, including a variety of proteins is disclosed.

Abstract: Systems and methods are provided for generating data for sensor system validation. A representative vehicle is equipped with a set of sensors positioned to provide a collective field of view defining a set of sensor locations as a set of master data and encompassing a field of view of a sensor positioned at any of the set of sensor locations. The set of sensor locations includes a sensor location at which no sensor of the set of sensors is placed. The representative vehicle is driven for a distance required for validation of a sensor system to provide master data representing the entire distance required for validation.

Abstract: An elastic multiple component fiber comprising a cross-section, wherein at least a first region of said cross-section comprises a polyurethaneurea composition; and comprising a second region.

Abstract: A dual-interface sewer cap removal device is provided. The device includes a base plate with a first side provided opposite a second side. A first interface is defined on the first side of the base plate. The first interface is designed to engage a slotted sewer cap. A second interface is defined on the second side of the base plate. The second interface is designed to engage a sewer cap. The second interface is structurally distinct from the first interface. An aperture is centrally disposed on the base plate.

Abstract: Disclosed are high-throughput vessel receiving systems and methods of receiving sample vessels, such as samples stored in test tubes. A system for receiving a plurality of individual vessels that each contains a sample, and systems and apparatus for guiding, reorienting, collecting, and transporting a plurality of articles, including vessels, are disclosed.

Abstract: Disclosed are high-throughput vessel sorting systems and methods of sorting sample vessels, such as samples stored in test tubes. A system for sorting a plurality of individual vessels that each contains a sample is disclosed.

Abstract: Some embodiments of the present disclosure may relate generally to software-based service platforms and graphical user interface (GUI) architectures for determining and presenting rule-based conclusions, along with explanations identifying the factor or factors influencing the conclusions. Other embodiments may be disclosed and/or claimed.

Abstract: Embodiments of the present invention provide a control system for a vehicle. The control system is configured to receive speed profile data indicative of a speed profile of the vehicle, wherein the speed profile represents one or more speeds at which the vehicle will be automatically controlled to travel at on a route ahead of the vehicle; receive route data indicative of the route ahead of the vehicle; determine, using the received speed profile data and the received route data, a representation comprising a relative position of the vehicle with respect to the route ahead and an indication of the speed profile on the route ahead; and output a signal indicative of the representation for provision to an output device.

Abstract: An explosion simulation system for simulating blast effects of an explosive device includes a transmitting device connected to the explosive device to transmit a virtual radio frequency blast wave upon activation; and attenuate the virtual radio frequency blast wave to match a mass of explosives used in the explosive device. The system also includes remote receiving devices comprising an audible alarm to indicate when the blast wave is received from the transmitting device. The receiving devices may get activated upon receiving the blast wave; calculate one or more effects of a blast of the explosive device by decoding the blast wave based on an explosive charge weight comprising a kg TNT equivalent of the explosive device, a distance, a peak incident pressure, a peak reflected pressure, and a peak reflected impulse; and display the effects of the blast in at least one category comprising an ear rupture threshold.

Abstract: Voice-controlled devices that include one or more speakers for outputting audio. In some instances, the device includes at least one speaker within a cylindrical housing, with the speaker aimed or pointed away from a microphone coupled to the housing. For instance, if the microphone resides at or near the top of the cylindrical housing, then the speaker may point downwards along the longitudinal axis of the housing and away from the microphone. By pointing the speaker away from the microphone, the microphone will receive less sound from the speaker than if the speaker were pointed toward the microphone). Because the voice-controlled device may perform speech recognition on audio signals generated by the microphone, less sound from the speaker represented in the audio signal may result in more accurate speech recognition, and/or a lesser need to perform acoustic echo cancelation (AEC) on the generated audio signals.

Abstract: An additive manufacturing machine that includes a wire supply including a wire drive configured to advance a wire at a wire feed rate and a wire heater configured to apply resistive heating to heat the wire. The additive manufacturing machine includes an additive head for emitting a laser beam to weld the wire to a substrate, a sensor configured to detect a weld parameter, and a controller operatively connected to the wire supply, additive head, and sensor. The controller is configured to determine a failure mode of the weld as the laser beam welds the wire to the substrate based at least in part upon the weld parameter. In response to determining the failure mode, the controller is configured to adjust at least one of the wire feed rate, the resistive heating, and a power of the laser beam as the laser beam welds the wire to stabilize the weld.

Abstract: A multi-factor probabilistic model evaluates user input to determine if the user input was intended for an on-screen user interface control. When user input is received, a probability is computed that the user input was intended for each on-screen user interface control. The user input is then associated with the user interface control that has the highest computed probability. The probability that user input was intended for each user interface control may be computed utilizing a multitude of factors including the probability that the user input is near each user interface control, the probability that the motion of the user input is consistent with the user interface control, the probability that the shape of the user input is consistent with the user interface control, and that the size of the user input is consistent with the user interface control.

Abstract: The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.

Abstract: A pressurized container assembly includes a pressurized container, a valve, and a shearing chamber. A flowable product and propellant are also provided within the container. The propellant is substantially non-soluble in the flowable product. Methods of producing a foamed flowable product using shearing chambers are also disclosed.

Abstract: Voice-controlled devices that include one or more speakers for outputting audio. In some instances, the device includes at least one speaker within a cylindrical housing, with the speaker aimed or pointed away from a microphone coupled to the housing. For instance, if the microphone resides at or near the top of the cylindrical housing, then the speaker may point downwards along the longitudinal axis of the housing and away from the microphone. By pointing the speaker away from the microphone, the microphone will receive less sound from the speaker than if the speaker were pointed toward the microphone). Because the voice-controlled device may perform speech recognition on audio signals generated by the microphone, less sound from the speaker represented in the audio signal may result in more accurate speech recognition, and/or a lesser need to perform acoustic echo cancelation (AEC) on the generated audio signals.

Abstract: The present disclosure relates to immunoassays for NF-L performed on liquid samples derived from physiological fluids such as venous blood to detect the presence or absence of a physiological condition by quantifying one or a combination of NF-L determinations at concentrations indicative of the condition.

Abstract: The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.