Abstract: A model generator receives inputs of formal descriptions of an expected behavior of an electronic block. The model generator generates one or more models. Each generated model has a deep learning architecture to simulate an electronic block based upon the formal descriptions of an expected behavior of the electronic block. The model generator can then train each model with the deep learning architecture to simulate the electronic block using the formal descriptions of an expected behavior of that electronic block as logical reasoning to constrain machine learning of that model from training data during training of that model to simulate the electronic block to be consistent with the logical reasoning.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula Ia: or a pharmaceutically acceptable salt thereof.

Abstract: According to one aspect of the present disclosure, a method of thumbnail personalization is provided. The method includes initializing a thumbnail-personalization engine that includes a multi-armed bandit (MAB) model. The method includes allocating first user traffic to the plurality of thumbnails. The method includes calculating a first thumbnail-conversion rate of each thumbnail of the plurality of thumbnails based on performance data associated with the first user traffic. The method includes allocating second user traffic to the plurality of thumbnails based on the first thumbnail-conversion rate. The method includes calculating a second thumbnail-conversion rate of the plurality of thumbnails based on performance data associated with the second user traffic. The method includes determining an updated set of parameters for each arm of the MAB model based on a data decay function or a sliding-window period applied to the first thumbnail-conversion rate and the second thumbnail-conversion rate.

Abstract: Embodiments of the present disclosure provide improved embedding of an application within another application. Specifically, embodiments provide improved interoperability mechanisms supporting such embedding utilizing access to a storage access API. The storage access API in some embodiments provides a particular user-facing application access associated with a first application to particular shared cookie(s) or other data utilized to access functionality of an embedded application from within the user-facing application. Embodiments additionally or alternatively account for security barriers or security requirements of applications and/or supporting applications, for example browser applications, that facilitate the access to the embedded application from within the user-facing application associated with the user-accessed application by utilizing a credential-based access component.

Abstract: A semiconductor device includes an n-type buried layer, a first N-well region, a p-type body region, a first source/drain region, a second source/drain region, a gate structure, a second N-well region, and a first silicide region. The n-type buried layer in a substrate. The first N-well region is over the n-type buried layer. The p-type body region abuts the first N-well region. The first source/drain region is in the first N-well region. The second source/drain region is in the p-type body region. The gate structure extends across a boundary of the first N-well region and the p-type body region. The second N-well region is over the n-type buried layer. The first silicide region forms a Schottky contact with the second N-well region.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: The present invention provides a system and method for identifying cancerous tissue based on analysis of histopathologic slides of prostate tissue. In certain embodiments, the system and method classify image information associated with a histopathologic slide based on cancer risk using a first machine learning algorithm trained using a first training set and providing mask information associated with cancer risk that is superimposed on the image data to highlight cancerous or high risk tissue.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a system and method for identifying cancerous tissue based on analysis of histopathologic slides of prostate tissue. In certain embodiments, the system and method classify image information associated with a histopathologic slide based on cancer risk using a first machine learning algorithm trained using a first training set and providing mask information associated with cancer risk that is superimposed on the image data to highlight cancerous or high risk tissue.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula Ia: or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a system and method for identifying cancerous tissue based on analysis of histopathologic slides of prostate tissue. In certain embodiments, the system and method classify image information associated with a histopathologic slide based on cancer risk using a first machine learning algorithm trained using a first training set and providing mask information associated with cancer risk that is superimposed on the image data to highlight cancerous or high risk tissue.

Abstract: Embodiments disclosed herein provide an organic matter processing apparatus and method for the use thereof to convert organic matter into a ground and substantially dried product. The apparatus uses a bucket assembly that can grind, paddle, and heat organic matter contained therein. The bucket assembly can include a metal housing that has a flat bottom surface with multiple support structures that hold respective impeller assemblies that rotate about respective vertical axes. The impeller assemblies each include cutting structures and other structures designed to mix and agitate matter contained in the bucket assembly. One or more blade arrays can be mounted in a vertical orientation on a side of the metal housing plate and assist in fracture cutting and grinding of contents contained in the bucket.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula Ia: or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure provides DCN-1 modulating compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions, and their use for treating sickle cell disorders, diseases, and conditions. Such compounds are of Formula I: or a pharmaceutically acceptable salt thereof.

Abstract: Embodiments of the present disclosure provide improved embedding of an application within another application. Specifically, embodiments provide improved interoperability mechanisms supporting such embedding utilizing access to a storage access API. The storage access API in some embodiments provides a particular user-facing application access associated with a first application to particular shared cookie(s) or other data utilized to access functionality of an embedded application from within the user-facing application. Embodiments additionally or alternatively account for security barriers or security requirements of applications and/or supporting applications, for example browser applications, that facilitate the access to the embedded application from within the user-facing application associated with the user-accessed application by utilizing a credential-based access component.

Abstract: Provided are methods for treating hypertrophic cardiomyopathy and diastolic dysfunction.

Abstract: Disclosed herein are compounds of the formula: A-L-R1(I), wherein the these variables are defined herein, as well as medical devices comprising said compounds. The present disclosure also provides pharmaceutical compositions comprising the compounds or medical devices disclosed herein. Further, the present disclosure provides methods of treatment using the compounds, medical devices, or pharmaceutical compositions disclosed herein.

Abstract: The present disclosure provides methods, composition and devices for performing convection-based PCR and non-enzymatic amplification of nucleic acid sequences. Techniques and reagents employed in these methods include toehold probes, strand displacement reactions, Rayleigh-Benard convection, temperature gradients, multiplexed amplification, multiplexed detection, and DNA functionalization, in open and closed systems, for use in nucleic tests and assays.