Abstract: The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

Abstract: The disclosure relates to a table (100). The table (100) has a table top (102), a plurality of legs (104) connectable to the table top (102), and an air purifier (106) adapted to be placed below the table top (102). A bottom side of the table top (102) is provided with at least one groove (112) extending in a circumferential direction for preventing liquid from traveling from an outer edge of the table top (102) along the bottom side of the table top (102) and reaching an inner section of the air purifier (106). The disclosure also relates to a method for purifying air using a table (100).

Abstract: The present invention provides a locking mechanism in a mobile terminal and a method of manufacturing the same. The locking mechanism comprises a slider, latch, button, and spring. The slider and latch include openings and may translate between a locked position and an unlocked position. The latch may include a protrusion that limits the translation of the slider and the latch when in the locked position. The button is located within the opening of the slider and the opening of the latch, and the spring member is fixed adjacent the latch. In an instance in which an external force is applied to the button, the external force deforms the spring member such that contact between a vertical edge of the protrusion and the spring is precluded allowing translation of the slider and the latch between the locked position and the unlocked position.

Abstract: The present disclosure is directed to processing imagery using one or more machine learning (ML) models. In particular, data describing imagery comprising a plurality of different and distinct frames can be received; and based at least in part on one or more ML models and the data describing the imagery, and for each frame of the plurality of different and distinct frames, one or more scores can be determined for the frame. Each score of the score(s) can indicate a determined measure of suitability of the frame with respect to one or more of various different and distinct uses for which the ML model(s) are configured to determine suitability of imagery.

Abstract: Methods, nodes and computer program products control radio channel deployment when using un-licensed carriers in a wireless communication network and control mobility and/or load balancing target selection when using un-licensed carriers. When performed in an access node, unlicensed carrier intrinsic cell channel load is determined in a cell served by the access node based on one or more predetermined channel load indicators and neighbor cell channel load information is obtained, from one or more neighboring access nodes. The neighbor cell channel load information includes unlicensed carrier channel load in respective cells based on the one or more predetermined channel load indicators. At least one channel deployment operation is initiated based on an outcome of one or more comparative operations including the determined unlicensed carrier intrinsic cell channel load and/or the obtained neighbor cell channel load information.

Abstract: Examples of a suspension are provided. The suspension includes a mount plate attached to a load beam at a suspension assembly attachment point. The suspension may include a first actuator and a second actuator located at the mount plate. The first actuator is shaped as a non-right angle parallelogram spanning across a first opening in the mount plate. The second actuator is shaped as a non-right angle parallelogram spanning across a second opening in the mount plate. The first and second actuators are configured to deflect the distal end of the mount plate, which causes the load beam to rotate with a rotation center located along the load beam.

Abstract: The present disclosure provides compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof. The provided compounds may be kinase (e.g., Janus kinase (JAK) (e.g., Janus kinase 2 (JAK2)) and/or cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 11 (CDK11)) inhibitors. Also provided are pharmaceutical compositions and kits including the provided compounds. Further provided are methods of using the provided compounds, pharmaceutical compositions, and kits (e.g., for treating a disease (e.g., proliferative disease) in a subject in need thereof).

Abstract: A computing device includes: a housing having a plurality of sides defining a housing interior; a first outer lens disposed on a first side of the housing; a second outer lens disposed on a second side of the housing; an image sensor in the housing interior, the image sensor having first and second capture regions; an optical divider in the housing interior, the optical divider configured to (i) direct light from the first outer lens along a first optical path, and (ii) direct light from the second outer lens along a second optical path; and a lens assembly between the optical divider and the image sensor, the lens assembly configured to (i) focus light received along the first optical path onto the first capture region of the image sensor, and (ii) focus light received along the second optical path onto the second capture region of the image sensor.

Abstract: The present disclosure relates to peptidic compounds of Formula A, A-II, A-III, B, or C, or salt or solvate thereof, compositions thereof, and methods of use thereof. The compounds of the present disclosure are useful for targeting CXCR4 for purposes such as imaging and/or therapeutics.

Abstract: The present invention is directed to QTY CCR9 and CXCR2 variant Fc receptor fusion proteins, methods for the preparation thereof and methods of use thereof.

Abstract: This disclosure describes, in part, systems for enabling facilities to implement techniques to determine when users are in possession of items when located within and/or exiting the facilities. For instance, a system may use one or more sensors to determine locations of a user that navigated through a facility. Additionally, the system may use one or more sensors to determine locations of an item while the item was located within the facility. The system may then determine a probability that the user was in possession of the item when in the facility and/or when exiting the facility based at least in part on the locations of the user and the locations of the item. If the system determines that the user was in possession of the item when exiting the facility, the system may charge a payment instrument of the user for a price of the item.

Abstract: A device may receive network data identifying a topology of network devices of a network, quality of service (QoS) rules for user equipment (UEs) and application flows associated with the network, QoS profiles for a radio access network (RAN) of the network, and service data flow (SDF) templates. The device may process the network data, with a model, to calculate a network device service level agreement (SLA) score, for each of the network devices on a sliding window, to generate network device SLA scores, and may aggregate the network device SLA scores to generate an end-to-end SLA score on the sliding window. The device may generate QoS configuration data based on the end-to-end SLA score, and may implement the QoS configuration data.

Abstract: The present disclosure relates to compositions including monoglycerides and co-surfactants. An exemplary embodiment includes about 40 wt % to about 99 wt % of one or more monoglycerides of a C4-C28 fatty acid, about 0.1 wt % to about 20 wt % of one or more salts of a C4-C28 fatty acid, and about 0.1 wt % to about 20 wt % of one or more zwitterions.

Abstract: Systems and methods for generating transient object references are provided. The systems and methods perform operations including establishing a session between a first entity and a second entity. The operations include identifying an object that the first entity is authorized to access according to a first set of access privileges. The operations include generating a reference associated with the object. The operations include temporarily authorizing the second entity to access the object using the reference according to a second set of access privileges, the second set of access privileges being derived from the first set of access privileges.

Abstract: A method of isotope-labelling a microbiota sample. It involves providing a first microbiota sample that was obtained from a given source; exposing the first microbiota sample to an isotope enriched medium; and culturing the exposed first microbiota sample in the isotope enriched medium to obtain an isotope-labelled microbiota sample, wherein the isotope labelled metaproteome of the isotope-labelled microbiota sample is taxon specific for taxa present in the first microbiota sample when initially obtained from the given source.

Abstract: This disclosure relates to techniques for a wireless device to perform channel state information reporting. The wireless device may receive channel state information reporting configuration information. The channel state information reporting configuration information may include an indication to use a wideband precoding matrix indicator format for 3GPP release 16 type II channel state information reporting. The wireless device may perform channel state information reporting using a different reporting configuration than 3GPP release 16 type II channel state information reporting using a wideband precoding matrix indicator format based at least in part on the channel state information reporting configuration information. The wireless device may also or alternatively perform 3GPP type I channel state information reporting using a unified spatial basis selection framework for rank indicators of 3 and 4 for any number of channel state information reference signal ports.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: The present application relates to sustained release formulations of crystalline drugs, comprising a crystalline drug core and a polymer shell, wherein the polymer comprises PLA and/or PLGA and the shell completely encapsulates the core. The sustained release formulations are suitable for drugs such as steroid or proteins. The present invention also relates to methods of the manufacture of the sustained release formulations, using either pressing alone or pressing in combination with heating.

Abstract: Examples of electronic devices are described herein. In some examples, an electronic device includes a camera. In some examples, the electronic device also includes a processor to start a lock timer to lock the electronic device in response to detecting that a first person leaves a field of view of the camera. The processor is also to adjust the lock timer in response to detecting a second person within the field of view of the camera.

Abstract: An apparatus and method of blind detection of binauralized audio. If the input content is detected as binaural, a second binauralization may be avoided. In this manner, the user experience avoids audio artifacts introduced by multiple binauralizations.