Abstract: Described herein are systems and methods for extending the dynamic range of assay methods and systems used for determining the concentration of analyte molecules or particles in a fluid sample. In some embodiments, a method comprises spatially segregating a plurality of analyte molecules in a fluid sample into a plurality of locations. At least a portion of the locations may be addressed to determine the percentage of said locations containing at least one analyte molecule. Based at least in part on the percentage, a measure of the concentration of analyte molecules in the fluid sample may be determined using an analog, intensity-based detection/analysis method/system and/or a digital detection/analysis method/system. In some cases, the assay may comprise the use of a plurality of capture objects.

Abstract: In one embodiment, a device obtains telemetry regarding processor hardware of a compute node in a containerized system, whereby the telemetry has been converted into a common data format. The device associates the telemetry with a microservice of an application executed by the compute node. The device generates, based on the telemetry, a control flow graph for the microservice associated with the telemetry. The device provides an alert for display based on the control flow graph for the microservice.

Abstract: A microfluidic system for processing a tissue sample. The system may comprise a microfluidic digestion device comprising an outlet. The system may further comprise a camera visually coupled to an interior of the microfluidic digestion device, configured to generate a stream of data comprising visual data of the tissue sample within the interior of the microfluidic digestion device. The system may further comprise a computing device configured to accept the stream of data from the camera as a plurality of images, and calculating an intensity of a red value of the tissue sample. The system may further comprise a microfluidic disaggregation device comprising an inlet fluidly coupled to the outlet of the microfluidic digestion device, an outlet, and a collection chamber fluidly coupled to the outlet of the microfluidic disaggregation device.

Abstract: A superabsorbent material generally free of organic solvents and having a high overall porosity and a high percentage of micropores are provided. The superabsorbent material is formed from a high-molecular weight linear water-soluble absorbent polymer and a non-reactive or latent crosslinking agent, and contains a plurality of micropores having a size of about 150 ?m or less. The superabsorbent material is formed into a variety of shapes having a high external surface to volume ratio.

Abstract: Lenses and methods are provided for improving peripheral and central vision for patients. The lenses improve vision by having an optic configured to provide optimal peripheral vision that minimizes off-axis astigmatism at, for example, 20 degree eccentricity, while maximizing on-axis visual acuity and contrast sensitivity. The method provides for the design of an IOL that reduces optical errors in an image produced at a peripheral retinal location of a patient's eye disposed at a distance from the fovea, while maximizing on-axis visual acuity and contrast sensitivity.

Abstract: A surgical microscope with a fluorescence excitation illuminator receives fluorescence emissions from a target, the surgical microscope having an optical output port. A tunable filter passes a filtered portion of light from the surgical microscope, the filtered light has wavelengths selected by the tunable filter and is provided to a high-resolution, broad-bandwidth electronic camera. The electronic camera converts light from the tunable filter to electrical signals. A processor processes the electrical signals to form an image of the target including estimated fluorophore depth, the image corrected for optical absorption and scattering parameters of the target. The processor also performs deformation modeling of the target to track tumor position changes during surgery. Embodiments track surface changes of the target using stereo cameras to support the deformation modeling, some images may include information from preoperative CT or MRI, and some images may map biomarkers like HbO2 and DexoHb.

Abstract: A heat integration process and system for a chemical recycling facility is provided that can lower the carbon footprint and global warming potential of the facility. More particularly, one or more heat transfer media may be used to recover heat energy from a waste plastic pyrolysis effluent and redistribute the recovered heat energy throughout the chemical recycling facility. Furthermore, a staged condensation configuration may be utilized to produce multiple pyrolysis oil streams and to provide heat to the heat transfer media. Thus, the global warming potential of the chemical recycling facility may be optimized and lowered due to the heat integration process and system herein.

Abstract: The present invention relates to methods of feeding polyphenols to animals, including associated feeds and preparation thereof, and methods of consuming animals fed the polyphenols.

Abstract: A computing system for treatment of a neural disorder of a user. The system comprises a processor, a memory, and an output device. The computing system further comprises an oscillator module adapted to run on the processor, thereby interacting with the output device to produce rhythmic sensory stimuli, perceivable by senses of the user, at at least one predetermined frequency to induce oscillations in a brain of the user and thereby to enhance neural activity of a neural circuit associated with the processing of a task. The computing system further comprises a content module stored in the memory interacting with the output device to produce content to engage the user. A method for treatment of a neural disorder in a user comprising providing rhythmic sensory stimuli, to induce oscillations in a brain of user to enhance neural activity of a neural circuit associated with the processing of a task.

Abstract: The invention provides fusion proteins that comprise a human IFN-?2, a first antigen-binding domain capable of binding to human PD-L1, a second antigen-binding domain capable of binding to human PD-L1 and to human IFN-?2, and methods of using the same.

Abstract: A winding device for adjusting the elastic energy of an overhead door spring system installed on a wall structure, the door having at least a door panel which can be moved up and down constrained within a track. The door also has a counterbalance system with a coil spring having a stationary end and a winding end. The door system also has a central shaft held within the counterbalance system. The winding device has a worm gear with a flange, or collar portion, a worm screw engaged by the worm gear, a box or container or a retainer to hold the worm gear and worm screw together in an engagement status. The worm gear is engaged with the central shaft by at least one fastener. It can also be used to lift said door directly when said spring is broken, or there is no spring at all.

Abstract: Exercise systems, including Pilates reformer systems, configured to provide feedback and suggestions based on a performance or an activity of the user. A system includes sensors for sensing physical aspects of and producing sensor data related to the user's performance of an exercise. The sensor data is processed to compute real-time and historical parameters. Real-time performance may be compared with historical performance and used to generate feedback and suggestions to be delivered to the user such that the user may change their activity based on the feedback or suggestions.

Abstract: In one aspect, an immunogen includes an immunogenic carrier comprising an RNA bacteriophage virus-like particle (VLP) and an antigenic SARS-CoV-2 stem-helix peptide linked to the immunogenic carrier. In another aspect, an immunogen includes an immunogenic carrier comprising an RNA bacteriophage virus-like particle (VLP) and an antigenic SARS-CoV-2 nucleocapsid (N) protein peptide linked to the immunogenic carrier. In one or more embodiments of either aspect, the immunogen may be a component of a pharmaceutical composition. In one or more embodiments of either aspect, the immunogen may be a component of a vaccine.

Abstract: A first drive acts on a machine element via a transmission and a second drive acts on the machine element directly. First and second closed-loop speed controllers determine respective first and second setpoint force values for the first and second drives with the aid of the difference between the setpoint speed value and of the actual speed value and activate the first drive and/or the second drive as a function of the respective first and second setpoint force values. Respective first and second pilot force values are determined from a first axis inertia scaled by a first scaling factor (?), and second axis inertia scaled by a second scaling factor (1??).

Abstract: Apparatuses and methods are provided to enable a receiver device monitoring a control channel configured for carrying information indicating transmission types of point-to-multipoint services detect a point-to-multipoint service of interest. The device can further detect an indication of a transmission type associated with the point-to-multipoint service of interest. In response a request can be sent for a configuration enabling reception of the indicated transmission type of the point-to-multipoint service of interest on a point-to-multipoint traffic channel. In the absence of said further detecting, the device can refrain from sending the request for the configuration for reception of the transmission type of the point-to-multipoint service.

Abstract: Some methods may involve receiving a first content stream that includes first audio signals, rendering the first audio signals to produce first audio playback signals, generating first calibration signals, generating first modified audio playback signals by inserting the first calibration signals into the first audio playback signals, and causing a loudspeaker system to play back the first modified audio playback signals, to generate first audio device playback sound. The method(s) may involve receiving microphone signals corresponding to at least the first audio device playback sound and to second through Nth audio device playback sound corresponding to second through Nth modified audio playback signals (including second through Nth calibration signals) played back by second through Nth audio devices, extracting second through Nth calibration signals from the microphone signals and estimating at least one acoustic scene metric based, at least partly, on the second through Nth calibration signals.

Abstract: Embodiments permit secure information exchange using lightweight data and near-field communication (NFC). A user can transmit lightweight data, such as one or more indicators (e.g., user indicator, scope indicator(s), documents indicator(s), etc.), to a receiving computing system via the user's wireless device and an NFC protocol. Because NFC transmissions are performed by co-located devices, this lightweight data transmission can trigger and/or continue a sophisticated workflow. For example, the receiving computing system can be associated with a product or service provider, and the lightweight data transmission can progress a workflow related to a particular product and/or service. The workflow progression can include accessing secure user information via the indicator(s) received over the NFC transmission.

Abstract: Method and for recording transactions on a distributed ledger, the method comprising the steps of generating a private and public key pair using an applet of a UICC within a device. Storing the generated private and public key pair within the UICC. Deriving from the public key of the generated private and public key pair an identifier. Adding one or more transactions to a block of a distributed ledger, wherein the one or more transaction is identified using the derived identifier.

Abstract: In one implementation, a method for providing security on externally connected controllers includes receiving, at a server system, operation information for a plurality of instances of a controller, the plurality of instances being installed across a plurality of devices; statistically analyzing, by the server system, the operation information; identifying, by the server system, one or more anomalous controller behaviors based on the statistical analysis; and providing, by the server system, information regarding the one or more anomalous controller behaviors on the controller as potential security threats.

Abstract: A method including receiving a request for an anchor associated with a location, determining whether the location includes a structure, in response to determining the location includes a structure, retrieve data associated with the structure and determine if a quality associated with the data associated with the structure meets a criterion, and in response to determining the quality meets the criterion, return an anchor in response to the request.