Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

Abstract: An example method includes receiving task identification information indicative of a manufacturing task to be performed on a workpiece, wherein the workpiece transfer system comprises a rail and a plurality of arms coupled to the rail, wherein each arm comprises (i) a plurality of arm linkages coupled at respective joints, (ii) an arm controller in communication with the supervisory controller, and (iii) respective joint controllers in communication with the arm controller and configured to actuate respective rotary actuators at the respective joints to move the plurality of arm linkages relative to each other: retrieving a motion plan corresponding to the manufacturing task and the workpiece: sending command signals to respective arm controllers to communicate respective command signals to the respective joint controllers and execute the motion plan; and once the final desired configuration is achieved, commanding the respective arm controllers to lock the respective joints.

Abstract: A device for sharing augmented reality content between users on a network. Augmented reality media may be curated, searched, selected to be viewed or created and represented by an icon representative of the media content.

Abstract: Surge arresters having secured MOV stacks. One surge arrester device includes a first housing portion including a first end and a second end, the first end including a first opening and the second end including a second opening, and a second housing portion protruding from an intermediate section of the first housing portion. The surge arrester device includes an MOV stack secured within the second housing portion by a MOV stack housing. The MOV stack is maintained within the second housing portion during a fault to ground condition of the surge arrester.

Abstract: Methods, systems, and devices for temperature exception tracking in a temperature log for a memory system are described. The memory system may store the temperature log separate from data to which the temperature information corresponds. For example, a memory device may store data in a relatively higher-level cell and the corresponding temperature information in a relatively lower-level cell. To perform a write operation, the memory system may determine a current temperature at which the data is being written or was written to a partition of a memory device and may indicate in the temperature log if the current temperature is entering a temperature range that is outside a threshold temperature (e.g., a nominal temperature). To perform a read operation, the memory system may determine if the data to read was written to the memory device outside the threshold temperature to determine whether to perform temperature compensation for the read operation.

Abstract: A computer platform is disclosed. The computer platform comprises a central processing unit (CPU) including at least one socket having a plurality of tiles and control circuitry to partition the socket into a plurality of sub-sockets and assign a unique identity to each of the plurality of sub-sockets for security verification, wherein each sub-socket comprises at least one of the plurality of tiles to operate as a cluster of resources.

Abstract: Processes for producing activated chromium catalysts such as titanated chromium/silica catalysts are disclosed, and these processes utilize a multistep process involving exposure to inert and oxidizing atmospheres at specific temperature conditions. The resulting activated chromium catalysts have unexpectedly high melt index potential and can produce ethylene-based polymers with lower gel counts in addition to higher melt indices.

Abstract: Provided herein are apparatus and methods for production of a chlorite salt, e.g., sodium chlorite, based on purification by recrystallization to achieve the desired purity.

Abstract: A first request to initiate a memory access transaction is received by a processing device of a memory sub-system from a host system. One or more host data items are received from the host system. The one or more host data items are stored in a memory buffer residing on a volatile memory device of the memory sub-system. In response to an initiation of one or more operations to commit the memory access transaction, the one or more data items are migrated from the memory buffer to a persistent memory device.

Abstract: Various implementations include a light including a central body and two or more lighting portions. The central body has a longitudinal axis, a first portion, and a second portion opposite and spaced apart along the longitudinal axis from the first portion. The two or more lighting portions each include two or more red-green-blue (RGB) light-emitting diodes (LEDs). The two or more LEDs of each of the two or more lighting portions are linearly spaced apart from each other such that each of the two or more lighting portions extend from the first portion to the second portion. The two or more lighting portions are circumferentially spaced apart from each other about the longitudinal axis.

Abstract: An improved external fixator assembly for fixating fractures that includes a proximal frame assembly, a distal frame assembly and a polyaxial joint. The polyaxial joint comprises articulating components that engage to have multi-axial or polyaxial translational motion to allow for distraction/reduction and adjustment of flexion/extension, radial/ulnar deviation, pronation/supination of the wrist to an optimal wrist position. The polyaxial joint may be lockable. Fixation screws are also provided for engaging the patient's bone tissue on opposite sides of a fracture.

Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.

Abstract: A firepit may include an aluminum top that may be mounted to a molded base where the top may be movable relative to the molded base to allow access to the propane tank stored within the base as well as provide access to other components of the firepit. The movable top may rotate or swivel about a pivot point to move the top away from the base to thereby allow access to the propane tank and other components without having to remove the heat conducting medium, the gas ring, the screen or cover, or any other components of the firepit that supply or provide the flames for the firepit.

Abstract: Variable geometry turbines having new configurations of vanes are disclosed. New methods for designating new configurations of vanes for geometry turbines having are also disclosed.

Abstract: The present disclosure in one aspect provides technologies for detection of pancreatic cancer, e.g., early detection of pancreatic cancer. In another aspect, technologies provided herein are useful for selecting and/or monitoring and/or evaluating efficacy of, a treatment administered to a subject determined to have or susceptible to pancreatic cancer. In some embodiments, technologies provided herein are useful for development of companion diagnostics, e.g., by measuring tumor burdens and changes in tumor burdens in conjunction with therapeutics. In some embodiments, technologies provided herein are useful for development of companion diagnostics, e.g., by identifying biomarkers in subjects' bodily fluid samples (e.g., blood samples) that are associated with therapeutic response.

Abstract: The technology relates in part to methods for controlling the activity or elimination of therapeutic cells using molecular switches that employ distinct heterodimerizer ligands, in conjunction with other multimeric ligands. The technology may be used, for example to activate or eliminate cells used to promote engraftment, to treat diseases or condition, or to control or modulate the activity of therapeutic cells that express chimeric antigen receptors or recombinant T cell receptors.

Abstract: The present invention relates to an applicator cap and containers for dispensing and applying a topical product, such as a lotion, cream, medicine, or liquid. Embodiments of the present invention comprise a top section, a base section, and an optional cap for the top section. The top section can comprise an upper face and at least two elongated sections extending downward from the upper face. The upper face further comprises a plurality of raised nubs around a central opening for dispensing the product. The base section is connected to the top section via corresponding coupling elements, and the base section is slidably movable relative to the top section. In an open position, the cylindrical tube and the central opening form a pathway for dispersion of the product. In a closed position, the cylindrical tube and central opening form a seal to prevent dispersion of the product.

Abstract: Various systems and methods for maintaining a record for a workpiece processed by a CNC electronically synchronized cell of a manufacturing assembly line are disclosed herein. Example embodiments involve a cell controller and a part-processing control system. The cell controller can be configured to: initialize a cell controller record; initiate a part assembly task involving at least one electronically synchronized part-processing operation and upon completion of each operation, update an inspection identifier of the cell controller.

Abstract: A lid may include first and second openings disposed within a spout. The first opening may provide a first fluid pathway to a fluid disposed in an attached container and the second opening may provide a second fluid pathway to a fluid disposed in the container. The lid may also include a spout at least partially defined by an outer wall. First and second openings may be disposed within the spout and the openings may be at least partially defined by the outer wall of the spout. A conduit, such as a straw, may be coupled to an opening. If desired, a closure may be connected to the lid and the closure may selectively close one or more of the openings.

Abstract: A tailgate for a pickup truck, in accordance with a non-limiting example, includes a body member having a first lateral side, a second lateral side that is opposite the first lateral side, a first edge configured to pivotally connect with a vehicle body, a second edge, and a surface extending between the first lateral side, the second lateral side, the first edge, and the second edge. A ramp support member extends between the first lateral side and the second lateral side at the second edge, the ramp support member including a first end and a second end.