Abstract: Modified probiotics, pharmaceutical compositions thereof, and methods of modulating and treating disorders are disclosed.

Abstract: Methods, compositions, and systems for treating subject(s) in need of plasma Factor VIII, particularly a subject having preexisting anti-FVIII inhibitory antibodies, are provided. The methods involve administering to the subject a therapeutically effective amount of an inflammation suppressor, a therapeutically effective amount of a CD8+ T cell depleting agent, and a therapeutically effective amount of a composition comprising a lentiviral vector (LV) comprising an optimized FVIII expression cassette expressibly linked to a megakaryocyte-specific promoter. Such methods, compositions, and systems are useful to treat subjects with blood clotting disorder(s), such as hemophilia A.

Abstract: Methods and systems for processing input from an image-capture device for gesture-recognition. The method further includes computationally interpreting user gestures in accordance with a first mode of operation; analyzing the path of movement of an object to determine an intent of a user to change modes of operation; and, upon determining an intent of the user to change modes of operation, subsequently interpreting user gestures in accordance with the second mode of operation.

Abstract: Processes and facilities for providing recycled content hydrocarbon products (r-products) from recycled content pyrolysis oil (r-pyoil) and recycled content pyrolysis gas (r-pygas). Processing schemes provided herein maximize use of recycled content pyrolysis products to provide a variety of recycled content end products.

Abstract: Frames for a head-mounted display may include a front frame portion, a facial interface portion with outer peripheral regions configured to flex to conform to a user's facial features when in use, and two upper support elements connecting the facial interface portion to the front frame portion. Intersection points between the upper support elements and the facial interface portion may be separated by a common interpupillary distance of expected users. Various other methods, head-mounted displays, frames and frame elements, and systems are also disclosed.

Abstract: A device for connecting a terminal of a battery module to an electrical conductor comprises a longitudinal insulation body having at least one housing for receiving the terminal, and an electrical conductor arranged in the longitudinal insulation body. The connection device further comprises a connection arrangement including an electrical connector configured to be inserted into the housing and to make electrical contact between the terminal and the electrical conductor in order to electrically connect them, and a latch. A visual lock indicator is disposed on the longitudinal insulation body so as to be at least partially concealed by the latch in a first latch position and to be fully exposed in a second latch position.

Abstract: A carbonation machine includes a carbonation head to sealingly couple to a bottle filled with liquid to be carbonated; a piping to introduce and compress carbon dioxide into a space within the bottle above a top surface of the liquid to a predetermined pressure level when the bottle is coupled to the carbonation head; a stirrer to stir the liquid to enhance absorption of carbon dioxide in the liquid when the bottle is coupled to the carbonation head; and a manually operated valve mechanism configured to be moved to any position between a closed position to an open position for user-controlled release of pressure within the space.

Abstract: Provided is napkin folding apparatus for folding a napkin around at least one piece of flatware forming a flatware bundle. The apparatus includes a napkin cartridge for receiving a plurality of napkins, at least one flatware cartridge for receiving a plurality of pieces of flatware, a folding assembly having a deck assembly for receiving one of the plurality of napkins and at least one of the plurality of pieces of flatware, and a rolling assembly for rolling the one of the plurality of napkins and the at least one of the plurality of pieces of flatware into the flatware bundle, a transport assembly including an actuator and a gripper assembly movable by the actuator for transporting the flatware and the flatware bundle, a taping assembly, a first lifting assembly, and at least one second lifting assembly.

Abstract: An oral care product comprises a package comprising a container and an applicator tip attached to the container. The applicator tip has a dispensing orifice in fluid communication with the container. The oral care product further comprises an oral care composition contained within the container of the package, wherein the oral care composition comprises an oral care active.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A communications system according to certain embodiments includes a mobile device and a second type of communications system, such as a landline telephone system, that share usage information. The shared information can include call logs of in-coming and out-going calls, missed calls, text messages, address book information, GPS data, internet browsing data, and the like.

Abstract: A medical devices en-vivo positional determination system and method of surgery using a registration system to create a 3D frame of reference from 2D images and in which the user uses his or her judgement to select points of interest within the 3D frame of reference more accurate hand-held drilling or cutting, using forward kinematic equations calculated on a microcomputer to provide a real-time display of the 3-linear position and 2-angular orientation of a hand-held medical instrument which is linked by a draw wire or a virtual draw wire to a gimbal so as to measure the angle and distance of the instrument from a fixed point.

Abstract: This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

Abstract: Disclosed herein is a method for polymerizing a compound in a gas phase reactor. The method includes at least passing a liquid catalyst to a catalyst inlet of a manifold assembly, passing a carrier gas to a carrier gas inlet of the manifold assembly, combining the liquid catalyst and the carrier gas in the main channel of the manifold assembly, and passing the combination of the liquid catalyst and the carrier gas to the reaction chamber. The present disclosure is also directed to manifold assemblies for communication with reaction chambers.

Abstract: The present invention relates to compounds that inhibit Protein Arginine N-Methyl Transferase 5 (PRMT5) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of treating cancer using the compounds and pharmaceutical compositions of the present invention.

Abstract: The specification relates to conjugates comprising a linker of Formula (IA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.

Abstract: A reconfigurable power circuit (400) includes a single one-way DC to DC power converter (220, 221). The reconfigurable power circuit is configurable by a digital data processor as one of three different power channels (230, 232, and 234). Power channel (230) provides output power conversion. Power channel (232) provides input power conversion. Power channel (234) provides bi-directional power exchange without power conversion.

Abstract: An apparatus including a multi-station processing chamber with a top plate and a bottom portion encloses stations each including a pedestal assembly. A spindle centrally located between the stations is configured to rotate about a central axis, and is electrically connected to the bottom portion. An actuator controls movement of the spindle in the Z-direction. An indexer connected to the spindle rotates with the spindle, and includes extensions each configured to interface with a corresponding substrate for substrate transfer. An electrically conductive interface movably connected to the top plate provides an RF return path. Another actuator coupled to the grounding interface controls movement of the electrically conductive interface in the Z-direction. The electrically conductive interface moves downwards in the Z-direction to make contact with the indexer when each of the plurality of extensions is parked and the spindle is moved to a lower position during plasma processing.

Abstract: The disclosure presented herein provides DNA constructs, recombinant cells comprising thereof, system comprising thereof, bacterial probes, and/or a recombinant cell decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying cells, preferably bacteria cells, and methods for using thereof.

Abstract: A computer-implemented method for generating and presenting an electronic display of guidance for performing a robotic medical procedure may include receiving a plurality of prior procedure data sets; receiving or identifying objective data defining one or more of a duration or a patient outcome of the robotic medical procedure; executing an algorithm to identify a pattern across the plurality of prior procedure data sets; receiving information about an instance of the robotic medical procedure to be performed in the future for a patient outside the population; automatically generating guidance for performing the robotic medical procedure; and generating and presenting an electronic display of the guidance for performing the robotic medical procedure.