Abstract: A cardiac pacemaker for a patient's heart, for example an ILP which realizes integrated circuit space conservation and simple design that covers many modes of operation even though robust behaviour requires complex dynamic adaptive algorithms. The pacemaker includes a processing unit, a detector and a pacing signal generator, wherein the processing unit, the detector and the pacing signal generator are electrically interconnected, wherein the detector is configured to detect electrical signals of the heart, for example an intracardiac electrogram, and to transmit these signals to the processing unit, wherein the processing unit is configured to perceive an intrinsic ventricular signal and an intrinsic atrial signal from the signals received from the detector, to enable or disable the perception of the intrinsic atrial signal, to produce a ventricular pacing control signal.

Abstract: This invention relates to a fixed-dose dry powder inhalation formulation comprising fluticasone propionate and albuterol sulfate, together with an ?-lactose monohydrate carrier. In the formulation, the albuterol sulfate stabilises fluticasone propionate.

Abstract: Systems and methods for providing an interbody implant are disclosed. According to some implementations, the implant includes an implant body having a cranial face and a caudal face disposed opposite the cranial face. In some implementations, the implant includes one or more primary fixation mechanisms, which in turn can include one or more anchor cavities defined by the implant body. In some cases, one or more anchors are configured to be housed at least partially within the anchor cavities in an undeployed position, and the anchors are configured to be translationally deployed to a deployed position in order to couple the implant to a bony endplate of a spinal vertebra. In some implementations, the implant includes one or more actuators configured to effectuate selective deployment of the anchors.

Abstract: A method of providing assistance to a rescuer to perform cardiopulmonary resuscitation (CPR) is disclosed. The method includes receiving sensor data from one or more sensors regarding CPR compressions. The method also includes determining, on a real-time basis, a CPR parameter value for each CPR compression. The method also includes determining a summarized CPR parameter value based on each CPR parameter value. The method also includes determining whether summarized CPR parameter value satisfies a CPR threshold value. In response to determining whether the summarized CPR parameter value satisfies the CPR threshold value, the method includes causing a user interface to provide feedback information for assisting the rescuer to perform CPR on a patient.

Abstract: A magnetic pocket for mobile devices (MPMD) includes a pocket-equipped article. The MPMD includes a pocket disposed on the pocket-equipped article. The pocket includes a top part and a bottom part. The top part of the pocket includes an opening. The MPMD includes a magnet. The magnet is enclosed in a material. The material fully covers the magnet. The material is removably attached to the pocket disposed on the pocket-equipped article.

Abstract: A joint connect assembly may include a metallic ring connector configured to couple with one or more tubular composite beams. The joint connect assembly may include a layer arranged between the metallic ring connector and an external surface of the one or more tubular composite beams. The layer may be formed of a material configured to reduce local stress concentrations on the one or more tubular composite beams. The material of the layer may be an elastomeric material, e.g., the layer may include at least one of a natural rubber, synthetic rubber, or a combination thereof.

Abstract: A bottle stopper adapted for self-opening and self-plugging a bottle, comprising a cylindrical cover having a bottom end and a top end. The cylindrical cover is sized and shaped to plug a bottle. A cartridge is encompassed by the cylindrical cover and has a fluid chamber; the cartridge also has at least one lateral protrusion thereon to form between the cartridge and the cylindrical cover. There is at least one fluid channel for fluidly connecting between a space below the bottom end and above the top end. A conduit having at least one inlet and at least one outlet is for fluidly connecting transferring the fluid of the fluid chamber to outside of the bottle stopper. An activation cap is mounted to push the conduit along a longitudinal axis of the cylindrical cover from a closed state to an open state.

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

Abstract: Disclosed herein are polypeptides that bind to the epithelial cell adhesion molecule (EpCAM) and programmed death-ligand I (PDL 1) receptors, nucleic acids encoding them, and methods for their use in treating or limited development of cancer, auto immune disease, or inflammation. The disclosure further provides nucleic acids encoding a polypeptide of the disclosure: expression vector comprising a nucleic acid of the disclosure operatively linker to a suitable regulatory control element, host cells comprising a polypeptide, fusion protein, nucleic acid, or expression vector of any embodiment of the disclosure, and pharmaceutical compositions, comprising the polypeptide, fusion protein, nucleic acid, expression vector, or host cell of any embodiment; and a pharmaceutically acceptable carrier.

Abstract: A drill rod spacer assembly is formed of a plurality of spacer members each movable to a first position, and a drive transfer arrangement configured operable for receiving a drive for moving a body. The body is configured for interacting with a spacer member while moving so as to move same to its first position. The drill rod spacer mover has a detent member configured operable for supporting a respective spacer member in its first position when the body moves to interact with another spacer member. More than one drill rod spacer mover can be arranged to form a drill rod spacer mover arrangement for operable use with a drill rod storage assembly.

Abstract: Device (10) for guiding a user to mark a core sample (12) carried by a core tube (14), the device (10) including: a housing (20) mountable relative to the core sample (12) or the core tube (14) and having a marking guide (22) configured to be arranged adjacent the core sample (12) to guide marking; a communications module (26) operable to communicate with the downhole tool (16) to receive data; a user interface (28) operable to convey perceptible feedback to the user; and a processor (30) and associated memory (32). The processor (30) is configured to store data in the memory (32) and determine a marking position based on the data, and operate the user interface (28) to direct the user to cause relative rotation of the marking guide (22) and the core sample (12) so that the marking guide (22) is aligned with the marking position, allowing the user to use the marking guide (22) to mark the core sample (12) at the marking position.

Abstract: An air turbine starter having a housing that includes an inlet and an outlet to define an air flow path from the inlet to the outlet. A stator includes a plurality of circumferentially spaced vanes extending into the air flow path and defined a stator core. A coating surrounds one or more portions of the housing, defining the housing core, or the stator, defining the stator core. The housing core or the stator core includes a first material having a first hardness and the coating comprises a second material having a second hardness.

Abstract: A system and method are provided for automating preparation of compound prescription at workstations having a user interface and a quantity input hardware, based on forecasted quantities, ordered quantities and simultaneous usage data. The method may include obtaining orders for compound prescriptions, via web clients, tracking information related to inventories, generating compounding tasks corresponding to the orders by analyzing ingredients necessary, prioritizing and assigning the compounding tasks to workstations, based on forecast demand, available supply, capacity, and the inventories, providing graphical user interfaces for users to process the orders at the workstations. In response to detecting a user of processing an order, the method may also include updating the inventories, updating the compounding tasks, and/or providing an update on the graphical user interfaces regarding a next compounding task performable at the workstation.

Abstract: The system uses machine learning to predict diseases or conditions and assess disease risk progression from routine healthcare test results, either at a single time point or across multiple time points. The system predicts the presence or absence of a disease or condition, including screening. Routine healthcare test results include a number of typical clinical measures (such as forty, fifty, sixty measures) each with a separate value. The system makes predictions regarding diseases or conditions. The system is configured to estimate disease probability, stratify patients by risk level, and generate risk trajectories over time. The framework is designed to be extensible to future disease categories, novel biomarkers, and evolving machine learning models. The methodology applies to any disease or condition where blood-based, genetic, imaging, environmental, or real-time physiological data provide diagnostic insights.

Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

Abstract: A network computer system records deposits to a donation funding account that is shared amongst a plurality of users. The donation funding account includes a total fund that is based on the recorded deposits for the plurality of users. The network computer system maintains an allocation profile for each of the plurality of users, where the allocation profile identifies, for each user, one or more user-selected organization recipients and an allocation of a portion of the total fund that is attributable to that user. In response to a given event, the network computer system automatically generates an output such as a donation acknowledgment report, based on the allocation profile specified by the respective user. The described by various examples, the output can be in the form of a visual representation and/or report.

Abstract: Systems, methods, and devices for payment product verification and authorization using a customer identifier are disclosed. In some aspects, techniques described herein relate to receiving, by a payment product provider and from a payment processor, a customer identifier; querying a datastore of customers of the payment product provider with a parameterized query, where the customer identifier is a parameter of the query; determining, based on the query, that the customer identifier is associated with customer profile data of the payment product provider; determining payment product data associated with the customer profile data; returning, by the payment product provider and to the payment processor, a positive eligibility indication based on the customer profile data and the payment product data; receiving, by the payment product provider and from the payment processor, a customer approval indication; and sending, by the payment product provider and to the payment processor, the payment product data.

Abstract: A static multiview display and method of static multiview display operation include micro-slit scattering elements configured to reflectively scatter out the guided light from the light guide as a corresponding plurality of directional light beams that encode view pixels of a static multiview image. The static multiview display includes a light guide configured to guide light and a plurality of the micro-slit scattering elements, each micro-slit scattering element of the micro-slit scattering element plurality is configured to reflectively scatter out a different one of directional light beams having a relative intensity and a direction that encode a corresponding view pixel of the static multiview image. The micro-slit scattering elements each comprise a sloped reflective sidewall having a slope angle that is tilted away from the propagation direction of the guided light that provides the reflective scattering.

Abstract: An image capture apparatus with an image sensor and lens assembly (ISLA). The ISLA includes an image sensor, a lens mount, a lens barrel, and a lens sub-barrel. A lens mount connects the ISLA within the image capture apparatus. The lens mount extends away from the image sensor. The lens barrel is in communication with the lens mount. Barrel lenses are located within the lens barrel. The lens sub-barrel is movably connected to the lens barrel, the lens mount, or both. A sub-barrel lens is located within the lens sub-barrel.

Abstract: An apparatus may have a neuromorphic architecture and facilitate parallel neural network workloads. The apparatus may include neurons and connections between the neurons. The neurons may perform computations in the neural network and produce payloads and may transmit payloads to each other in the form of spikes. The spike messages may be orthogonally modulated spikes that facilitate executions of the neural network to process multiple inputs to the neural network through parallel workloads. A spike message may indicate a payload and identify the workload through which the payload is produced. A neuron may combine multiple spikes into a combined spike. The combined spike may represent all the payloads and workloads in the spike messages. The neuron may send the combined spike to another neuron, which may decode the combined spike to obtain a payload for performing a neural network operation for a workload that it is assigned to.