Abstract: This disclosure provides compounds of Formula (I), Formula (II), and pharmaceutically acceptable salts thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3K?). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) PI3K? activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.

Abstract: An aircraft that includes a fuselage, right and left wings coupled to the fuselage, struts that are connected to and that extend outward from an underside of the wings, and engines mounted to the struts. The struts are configured to locate the engines in an overwing position.

Abstract: A quantum circuit for a lattice gas automata simulation includes an initialization step performed by setting up, for the quantum circuit, a position register, a channel register and a first ancilla register. To the position register, the channel register and the first ancilla register are applied in a sequential order: (i) a collision step constructed using a first set of multi-controlled gates, a second set of multi-controlled gates, and four CX gates arranged between the first set and the second set, the collision step being applied to the channel register and the first ancilla register; (ii) a mapping step constructed using two Hadamard gates and four multi-controlled SWAP gates, the mapping step being applied to the channel register and the first ancilla register; and (iii) a propagation step being applied to the position register and the first ancilla register.

Abstract: Systems and methods are provided for evaluating aggregate risk exposure of insurance policies associated with a geographical area. An insurance system may include an aggregate risk management system, which calculates an aggregate risk exposure of insurance policies associated with a geographical area, and compares the aggregate risk exposure with a maximum tolerable risk exposure for the geographical area. Based on the comparison, the aggregate risk management system determines whether more insurance policies may be issued associated with the geographical area. The aggregate risk management system may issue a block at an insurance system to prevent new insurance policies associated with a geographical area based on the aggregate risk exposure for that geographical area.

Abstract: An apparatus of the subject technology includes a first device in radio frequency communication with a plurality of second devices. The first device includes a transducer and a processor. The transducer measures an elevation of the first device with respect to a device of the second devices. The processor determines possible values of a three-dimensional (3D) position of the first device and selects one of the possible values as the 3D position of the first device based at least on the measured elevation.

Abstract: One example described herein can involve a system that receives, from a user, a structured document that describes one or more conditions selected by the user to customize one or more electronic data structures. The system can also query a database to retrieve data from the database. The system can then execute an interpreter program, which can ingest the structured document and the data, identify a subset of the data that satisfies the condition(s), and generate the one or more electronic data structures based on the subset of the data. The electronic data structure(s) can include the identified subset of the data and exclude a remainder of the data. The system can compact the electronic data structure(s) by removing empty fields therein. The system can then provide the compacted data structure(s) to the user.

Abstract: An information processing device includes a display, a communication interface configured to receive signals from a tap device, one or more processors, and one or memories storing instructions. Upon execution by the one or more processors, the instructions cause the one or more processors to: display a plurality of icons on the display in a predetermined pattern as a graphical user interface; in response to a selection signal received from the tap device, select one of the plurality of displayed icons; in response to an activation signal received from the tap device, activate a function corresponding to the selected icon; and in response to a shift signal received from the tap device, shift the plurality of icons to different positions in the predetermined pattern.

Abstract: Novel tools and techniques are provided for implementing software-based network probes for monitoring network devices for fault management. In various embodiments, a computing system may receive, from at least one software-based network probe, a first alert associated with a first device among layer 4 devices disposed in a plurality of networks; may parse and store first alert data from the received first alert in a database, in a standardized format; may perform, using an enrichment system, enrichment of the first alert data, by retrieving first enrichment data from one or more second databases and adding the first enrichment data to the parsed and formatted first alert data in the first database to form first consolidated alert data; and may send the first consolidated alert data to a fault management system for display to a user to facilitate addressing of the first alert by the user.

Abstract: The present disclosure describes a system for launching an activation device to a frac tree, to a frac tree including the system, and to a method of remotely launching an activation device into a frac tree. The activation device is pneumatically conveyed through a pneumatic line between a loading station located remotely from the frac tree, to a staging valve system adapted to connect to the frac tree. The staging valve system stages the activation device from a low pressure zone above the staging valve system to a high pressure zone in the frac tree.

Abstract: A wafer shape metrology system includes a wafer shape metrology sub-system configured to perform one or more stress-free shape measurements on a first wafer, a second wafer, and a post-bonding pair of the first and second wafers. The wafer shape metrology system includes a controller communicatively coupled to the wafer shape metrology sub-system. The controller is configured to receive stress-free shape measurements from the wafer shape sub-system; predict overlay between one or more features on the first wafer and the second wafer based on the stress-free shape measurements of the first wafer, the second wafer, and the post-bonding pair of the first wafer and the second wafer; and provide a feedback adjustment to one or more process tools based on the predicted overlay. Additionally, feedforward and feedback adjustments may be provided to one or more process tools.

Abstract: The present disclosure relates generally to an escape room game that includes a plurality of puzzles corresponding to different solutions to be solved by a player in a specific order and within a predetermined period of time and in a room with defined boundaries for successful completion of the escape room game. The players can wager on a predicted level of performance of the player in the escape room game. Awards are provided by the gaming system based on the wagers and an actual level of performance of the player in solving one or more of the puzzles.

Abstract: In an embodiment, a method for operating a plurality of delay units include supplying to a first delay unit in a chain an input signal that propagates along delay units in the chain, generating a clock signal as a logic combination of signals input to and output from delay units in the chain and forwarding a feedback signal to the first delay unit in the chain via a first feedback signal path from a last delay unit in the chain to the first delay unit in the chain and a second feedback signal path from an intermediate delay unit in the chain to the first delay unit in the chain, the intermediate delay unit being arranged between the first delay unit and the last delay unit.

Abstract: A computational evidence platform extracts clinical concepts from medical evidence sources and creates a database of elemental diagnostic factors and elemental investigations links to medical conditions. Input from a person groups factors and investigations makes corrections and adds a ranking. Elemental factors and investigations do not include information specific to their associated conditions but include synonyms and a link to a medical ontology. A patient state is determined by extracting patient known diagnostic factors and investigation results from the patient chart. These known factors and results are matched to the database and a ranking of likely conditions are output. Next-best actions per condition are output by determining factors not yet known and investigations not yet performed. Next-best actions across conditions are determined by performing a recursive tree search of the database and assuming that unknown factors are now known to generate a score for each assumption.

Abstract: This invention discloses a monocrystalline superconductor and a method for fabricating the monocrystalline superconductor. The method includes providing an ink comprising a mixture of powders of RE2O3, BaCO3, and a Ba and/or Cu precursor with a binder and a solvent; extruding the ink into micro-lattices layer by layer to form a three dimension (3D)-printed object with a desired architecture; sintering the 3D-printed object to obtain a polycrystalline 3D-printed object comprising REBa2Cu3O7-x(RE123)+RE2BaCuO5 (RE211); and performing single-crystal growth of monocrystalline structures from the polycrystalline 3D-printed object to fabricate the monocrystalline superconductor, wherein RE represents a rare-earth element selected from the group consisting of Y, La, Sm, Nd, Gd, and Eu.

Abstract: In an embodiment, a transistor device is provided that includes a semiconductor substrate having a first major surface, and a columnar trench arranged in the first major surface and having a lower surface and a side wall, the side wall extending from the lower surface to the first major surface. A gate electrode positioned in the columnar trench is electrically insulated from the semiconductor substrate by a gate dielectric. A field plate positioned in the columnar trench under the gate electrode is electrically insulated from the gate electrode and the semiconductor substrate by a field dielectric. The gate electrode is asymmetric about a longitudinal axis of the columnar trench. The field plate includes a field plate extension which extends from the field plate towards the first major surface and laterally adjacent to the gate electrode.

Abstract: A pervasive realtime framework supports the execution of realtime software applications with high-level functions that significantly reduce the effort and time needed to develop realtime software applications in a new operating environment paradigm in which realtime connections between network nodes are pervasive. The pervasive realtime framework handles the complex tasks of connecting to communicants, virtual areas, and other network resources, as well as switching those connections in response to user inputs and thereby enables software application developers to focus on developing high-level realtime software application functionality.

Abstract: An indicator light assembly for a vehicle includes a housing. The housing includes a casing and a cover. The cover is connected to the casing. A first light channel is formed in the housing. A second light channel is formed in the housing. A first indicator and a second indicator are formed on the cover. A first light source is disposed in the housing and configured to emit light through the first light channel to illuminate the first indicator. A second light source is disposed in the housing and configured to emit light through the second light channel to illuminate the second indicator.

Abstract: Shaped catalyst compositions and methods for making and using the shaped catalyst compositions are provided. In an exemplary a catalyst active phase includes a MoVTeTaOx catalyst. The composition also includes a support phase, wherein the support phase includes fumed silica, and wherein the catalyst active phase and support phase form a heterogeneous mixture.

Abstract: Systems, devices, and methods are disclosed herein for monitoring physiological data of subjects seated on a toilet, including systems, devices, and methods for monitoring light signals or readings on a toilet seat. In some embodiments, systems, devices, and methods disclosed herein include a set of sensors integrated into a seat (e.g., of a toilet), with the sensors being configured to measure multiple light signals associated with unique optical paths across a portion of tissue of an individual seated on the seat.

Abstract: A wearable Doppler blood flowmeter can be used with an inflatable cuff to measure blood flow, such as for assessing peripheral artery disease (PAD). The present approach can include techniques such as providing or using a wearable acoustic Doppler blood flowmeter, without requiring the intricate manipulation of a handheld Doppler probe. The system can select a pair of acoustic transmitter and acoustic receiver from a set of more than two transducers, including one or more of different locations, orientations, or spacings, such as to vary a targeted region. The RF echo response signal can be translated to an audio response signal. An audio response signal injection circuit can adaptively inject a noise or other enhancement signal, such as to help improve perceptibility of an audible characteristic of pulsatile arterial blood flow. A trained machine learning model can be employed to select or adjust operating settings, to assess diagnostic information, or both.