Abstract: In order to provide a treatment system for treating workpieces—in particular, vehicle bodies—which system has a simple structure and enables energy-optimized and/or quality-optimized workpiece treatment, it is proposed that the treatment system comprise the following: a housing which surrounds a treatment chamber; a cooling gas flow supply for supplying a cooling gas flow to the treatment chamber; and a heating region which is adjacent to the cooling gas flow supply or forms a component thereof and which can preferably be heated to a temperature which is above a temperature of the cooling gas flow.

Abstract: Oral care light devices, kits, and methods are provided. An oral care light device may include a housing, a light source positioned in the housing, the light source being capable of emitting electromagnetic radiation having an average light intensity of about 150 mW/cm2 or greater. The oral care light device may include a battery and may be portable. A kit may include an oral care light device and a whitening composition. A method of whitening teeth using an oral care light device may include applying a whitening composition including a bleaching agent to a tooth, maintaining the whitening composition on the tooth for a first time period without activating the light source, and, after the first time period, activating the light source to direct the electromagnetic radiation toward the tooth for a second time period.

Abstract: This disclosure provides compounds of Formula (I), Formula (II), and pharmaceutically acceptable salts thereof, that inhibit phosphatidylinositol 4,5-bisphosphate 3-kinase (PI3K) isoform alpha (PI3K?). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) PI3K? activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.

Abstract: Apparatus and associated methods relate to a catheter manipulation handle with user interface controls for steering a catheter in situ while providing an augmented (e.g., motorized, powered and tunable precision steering, and perforation safeguards) control and feedback user experience. In an illustrative example, the catheter manipulation handle may provide motor assisted operation to automatically rotate and/or deflect a distal tip of the catheter to steer and guide the distal tip to a target location in the patient's vasculature system. The augmented feedback may include, for example, haptic feedback via the handle. Haptic, audible, and/or visual feedback via the handle may indicate, for example, proximity or engagement of the distal tip with sensitive tissue. In some examples, the handle's augmented operation may advantageously amplify feedback signals to enhance the user's perception of the patient's safety with respect to the safe passage of the distal tip through the patient's vasculature.

Abstract: A head-mounted device may have a left display and a right display that provide respective left and right images. Left and right optical combiner systems may be configured to pass real-world light to left and right eye boxes while directing the left and right images respectively to the left and right eye boxes. Misalignment of the left and right images with respect to the left and right eye boxes may be detected using gaze tracking systems, using cameras such as front-facing cameras in conjunction with a database of known real-world object properties, using visual inertial odometry systems formed from cameras and inertial measurement units, or using one or more sensors in a portable head-mounted device case or other item with a receptacle configured to receive a head-mounted device. Compensating adjustments may be made to the images based on the measured misalignment.

Abstract: Provided herein is an ophthalmic composition. In some embodiments, the ophthalmic composition includes a low concentration of an ophthalmic agent for treatment of an ophthalmic disorder or condition; and an ophthalmically acceptable carrier, wherein the ophthalmic agent is distributed with substantial uniformity throughout the ophthalmically acceptable carrier. Further disclosed herein include an ophthalmic composition including a low concentration of an ophthalmic agent and deuterated water. Also disclosed herein are methods of arresting or preventing myopia development by administering to an eye of an individual in need thereof an effective amount of an ophthalmic composition as described herein.

Abstract: An apparatus includes a memory and a processor. The processor is configured to execute instructions stored in the memory to determine interrupt events from a plurality of notification events generated by one or more of a plurality of computer systems; receive alert data indicating occurrence of monitored conditions in a managed information technology environment; assign, based on the alert data, incidents to the responder; modify, with respect to the responder, a notification configuration based on resolution data associated with the incidents and the interrupt events; and transmit a notification to the responder according to the modified notification configuration in response to assigning a new incident to the responder. The interrupt events are determined based on respective corresponding notification events being sent in respective manners designed to immediately alert a responder.

Abstract: A collapsible rotor assembly and a method to assemble the rotor assembly are disclosed. The rotor assembly may include a mast, a blade, a first arm and a second arm. The rotor assembly may further include a first connection member attached to a mast top portion and a second connection member attached to a mast bottom portion. The rotor assembly may additionally include a third connection member attached to a blade top portion and a fourth connection member attached to a blade bottom portion. A first arm distal end may be pivotally attached with the first connection member and a first arm proximal end may be pivotally attached with the third connection member. Furthermore, a second arm distal end may be removably attached with the second connection member and a second arm proximal end may be pivotally attached with the fourth connection member.

Abstract: In one embodiment, external API vulnerability assessments may include detecting, by a process, usage of an external application programming interface in execution of an application; transmitting, by the process, a query to the external application programming interface for a list of one or more components of the external application programming interface; generating, by the process, a vulnerability assessment for the application based on a response to the query; and performing, by the process, one or more mitigation actions based on the vulnerability assessment.

Abstract: A heat integration process and system for a chemical recycling facility is provided that can lower the carbon footprint and global warming potential of the facility. More particularly, one or more heat transfer media may be used to recover heat energy from a waste plastic pyrolysis effluent and redistribute the recovered heat energy throughout the chemical recycling facility. Thus, the global warming potential of the chemical recycling facility may be optimized and lowered due to the heat integration process and system herein.

Abstract: An imaging device for capturing images viewed from an optical viewing device. The imaging device includes a housing having a bracket for attaching the imaging device to the optical viewing device. The imaging device captures a sequence of images viewed from the optical viewing device, determines an image quality score for each image in the sequence of images, and selects a subset of images from the sequence of images based on the image quality score determined for each image in the sequence of images. The imaging device displays the subset of images, receives a selection of one or more images from the subset of images, and stores the one or more images selected from the subset of images.

Abstract: The present invention provides a method for producing a full engagement Pittsburgh male lock using specific cutting assemblies and protocols that reduce the amount of metal that is removed from the male portion of the corner notches in the duct. Forming of the male portion of the lock is done after the connecting flange forming has been completed as opposed to before the connecting flange forming has been completed.

Abstract: The present invention relates to improved synthetic routes of synthesizing adagrasib. The invention also provides intermediates used in the provided synthetic routes.

Abstract: Computing platforms, systems, methods, and storage media for providing cybersecurity simulation and training are disclosed. Exemplary implementations may: generate a cybersecurity simulation comprising a set of simulation elements selected from a simulation and training database; in response to detection of a cybersecurity simulation completion condition, dynamically generate a cybersecurity training course comprising a set of training elements corresponding to the set of simulation characteristics, the set of training elements selected from the simulation and training database; and in response to identification of a change to the cybersecurity simulation, modify the cybersecurity training course based on the identified change to the cybersecurity simulation.

Abstract: Processing gesture input includes obtaining hand tracking data for a hand from one or more sensors, wherein the hand performs a pinch in the hand tracking data, determining a hand position and a hand orientation for the hand from the hand tracking data, applying a predefined offset from the hand position based on the hand orientation to determine a pinch centroid, and determining an input location based on the pinch centroid. The pinch centroid is used in an indirect motion mapping pipeline to determine characteristics of user input based on user motion.

Abstract: Systems, devices, and methods are provided for trunk and branch blockchain ledger architecture for validation of real-world claims. Claims may relate to objective claims, such as an individual's work history or whether an organization has insurance coverage. Trunks and branches may be used to implement a network of cross-ledger claims and endorsements. A first entity (e.g., endorser) may make a claim on a first branch blockchain ledger that is controlled by the first entity. A second entity (e.g., endorser) may review the claim, determine whether it is true, and then produce an endorsement on a second blockchain ledger that is controlled by the second entity. The endorsement may be an encoded version of the claim that cannot be used to reverse-engineer the claim. An endorsement pointer may be recorded to the first branch blockchain ledger that references the endorsement recorded by the second entity to the second blockchain ledger.

Abstract: A vehicle comprising a compressor and a manifold physically and fluidly coupled to the compressor.

Abstract: Disclosed systems and methods herein provide for high bandwidth processing using a plurality of compute-memory chiplets. A computing package may be configured with a plurality of the compute-memory chiplets in order to perform processing operations in connection with a large language model. The compute-memory chiplets may be configured to operate using small, low-power computing dies that can efficiently operate for workloads with low arithmetic intensity.

Abstract: A patient interface to deliver a flow of air at a positive pressure with respect to ambient air pressure to an entrance to the patient's airways to ameliorate sleep disordered breathing includes a frame assembly and a cushion assembly configured to removably and repeatably connect to the frame assembly. The frame assembly and the cushion assembly form at least part of a plenum chamber pressurizable to a therapeutic pressure. The cushion assembly comprises a one-piece construction including a seal-forming structure configured to form a seal with a region of a patient's face surrounding the entrance to the patient's airways and a frame connection structure configured to removably and repeatably connect the cushion assembly to the frame assembly. The seal-forming structure comprises a first elastomeric material and the frame connection structure comprises a second elastomeric material, the first elastomeric material comprising a lower durometer or hardness than the second elastomeric material.

Abstract: A polymer composition for producing gel extruded articles is described. The polymer composition contains one or more high density polyethylene polymers combined with one or more olefinic copolymers. In order to form gel extruded articles, the polymer composition is combined with a plasticizer. In one embodiment, the polymer composition is used to form a porous membrane for use as a separator in electronic devices. The presence of the olefinic copolymer can increase the adhesive characteristics of membranes made from the composition when placed in contact with an anode and/or a cathode. When producing porous membranes, the olefin copolymer can also decrease the shutdown temperature and increase wettability properties.