Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract: A telephony application host has a web service environment and a telephony application proxy. The web service environment is adapted to host one or more instances of a telephony application. The telephony application proxy is adapted to receive telephony messages associated with the one or more instances of the telephony application and to proxy each received telephony message into a web request. The telephony application is adapted to process the web request within the web service environment.

Abstract: A method and apparatus for electromagnetic navigation of a surgical probe near a metal object. The electromagnetic navigation system includes a transmitter coil array and a shield. The transmitter coil array has a plurality of transmitter coils and is operable to generate the electromagnetic field to navigate the probe. The shield is positioned adjacent the metal object and is operable to shield the metal object from the electromagnetic field generated by the transmitter coil array, such that the shield substantially reduces distortion of the electromagnetic field by the metal object.

Abstract: A cell-array battery is disclosed having end-of-life cells that can be activated at the end of a battery's life to, illustratively, neutralize the toxic chemicals inside the battery. In one embodiment, neutralization of the electrolyte in the battery is achieved through immobilization of the electrolyte at the end of the life of the battery by, for example, a vitrification process. Using electrowetting techniques, the electrolyte is made to contact a neutralizing substance between the nanostructures in one or more end-of-life cells, thus causing a reaction that results in the electrolyte becoming immobilized by, for example, a polymer substance. In a second illustrative embodiment, when the electrolyte contacts the substance between the nanostructures in one or more end-of-life cells, the chemical composition of the electrolyte is changed into a less toxic chemical compound, thus neutralizing the electrolyte.

Abstract: A control pedal disabling device includes a housing having a side opening or notch for receiving a pedal assembly component. The opening has a forward surface for bearing against the underside of a pedal assembly component. A rod is slidably mounted to the housing. The rod is movable across the opening to trap the pedal assembly component in the opening. The rod is also movable forwardly from the housing to bear against a vehicle floor, thereby preventing movement of the pedal assembly component toward the vehicle floor.

Abstract: A representation of a prosthesis opening is created and a device having a marker is tracked through the opening while monitoring the relative positions of the opening representation and the marker on a display. In one alternative, a representation is made on a display of the center of the contralateral stump opening and an electromagnetic marker coil that is secured to an endovascular delivery device, and the marker and delivery device are guided into the opening, while monitoring the relative positions of the opening center and the electromagnetic marker coil representations. In another alternative, one or more markers are positioned in the vicinity of the prosthesis opening and a device having a marker is tracked to the one or more markers and through the opening where the device is one of a guidewire and a catheter, while monitoring the relative position of the markers on a display.

Abstract: A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.

Abstract: A cell-array battery is disclosed having end-of-life cells that can be activated at the end of a battery's life to, illustratively, neutralize the toxic chemicals inside the battery. In one embodiment, neutralization of the electrolyte in the battery is achieved through immobilization of the electrolyte at the end of the life of the battery by, for example, a vitrification process. Using electrowetting techniques, the electrolyte is made to contact a neutralizing substance between the nanostructures in one or more end-of-life cells, thus causing a reaction that results in the electrolyte becoming immobilized by, for example, a polymer substance. In a second illustrative embodiment, when the electrolyte contacts the substance between the nanostructures in one or more end-of-life cells, the chemical composition of the electrolyte is changed into a less toxic chemical compound, thus neutralizing the electrolyte.

Abstract: This Invention Relates To Novel Glucocorticoid Receptor Agonists of Formula (I): and to processes and intermediates for their preparation. The present invention also relates to pharmaceutical compositions containing these compounds, to their combination with one or more other therapeutic agents, as well as to their use for the treatment of a number of inflammatory and allergic diseases, disorders and conditions.

Abstract: Embodiments of the invention provide a substrate with a device layer having different crystal orientations in different portions or areas. One layer of material having one crystal orientation may be bonded to a substrate having another crystal orientation. Then, a portion of the layer may be amorphized and annealed to be re-crystallized to the crystal orientation of the substrate. N- and P-type devices, such as tri-gate devices, may both be formed on the substrate, with each type of device having the proper crystal orientation along the top and side surfaces of the claimed region for optimum performance. For instance, a substrate may have a portion with a <100> crystal orientation along a top and sidewalls of an NMOS tri-gate transistor and another portion having a <110> crystal orientation along parallel top and sidewall surfaces of a PMOS tri-gate transistor.

Abstract: A method for monitoring laser light launched into a core of a single mode fiber includes launching a portion of light directly into the cladding about the core. The cladding launched light is a known fraction of the core launched light and can be monitored by placing a detector about the cladding. Detected light including light that was launched into the cladding and has leaked through the cladding is used as a known fraction of light in the core and can be used to control the laser light source. This can be done with a straight section of single mode optical fiber and does not require bending the fiber. Advantageously, most of the core launched light remains in the core as guided light.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt and/or solvate (including hydrate) thereof; and the use of a compound of formula (I) in the treatment of a TNF-mediated disease, disorder, or condition, or a p38-mediated disease, disorder, or condition, in particular the allergic and non-allergic airways diseases, more particularly obstructive or inflammatory airways diseases, preferably chronic obstructive pulmonary disease.

Abstract: A method and apparatus for registering physical space to image space is disclosed. The system allows for determining fiducial markers as pixels or voxels in image data. The system can correlate and register the determined fiducial points with fiducial markers in physical space.

Abstract: A process for making a compound of formula (I), said process comprising a) reacting a compound of formula (II) with: i) a compound of formula (III) by nucleophilic aromatic substitution of X2 and ii) a compound of formula (IV) for example by nucleophilic aromatic substitution b) where necessary, converting X1 to a carboxylic acid; and c) coupling of the carboxylic acid group to an appropriate heterocyclic amine; wherein all variables are as defined in the description.

Abstract: One or more markers or sensors are positioned in the vasculature of a patient to facilitate determining the location, configuration, and/or orientation of a vessel or certain aspects thereof (e.g., a branch vessel), determining the location, configuration and/or orientation of a endovascular devices prior to and during prosthesis deployment as well as the relative position of portions of the vasculature and devices, generating an image of a virtual model of a portion of one or more vessels (e.g., branch vessels) or devices, and/or formation of one or more openings in a tubular prosthesis in situ to allow branch vessel perfusion when the prosthesis is placed over one or more branch vessels in a patient (e.g., when an aortic abdominal artery stent-graft is fixed to the aorta superior to the renal artery ostia).

Abstract: One or more localization markers are implanted in a patient's vessel to provide a virtual image of a portion of the vessel, provide a target for deploying a prosthesis, and/or facilitate post operative surveillance of a deployed prosthesis (e.g., to measure prosthesis migration and/or aneurysm elongation). In the case of providing a target or facilitating surveillance, one or more localization markers also can be provided on the prosthesis (e.g., the proximal end portion of the prosthesis) and the position of the prosthesis marker(s) monitored relative to the implanted marker(s). In another embodiment, one or more localization markers are provided adjacent to one opening of a tubular prosthesis to assist with cannulation of the opening. In one example, one or more localization markers are provided on the contralateral stump of a modular bifurcated stent-graft (e.g., to assist a surgeon with inserting a contralateral stent-graft into the contralateral stump of a modular bifurcated stent-graft).

Abstract: A method and circuit is disclosed for a laser system wherein the power of the laser signal is kept at a constant near optimum value and a portion of an frequency doubled output signal is monitored and detected so that noise within the frequency doubled output signal can be minimized. A feedback signal is used to dither the temperature of a frequency doubled crystal so as to minimize the noise in the frequency doubled output signal.

Abstract: A branch vessel in a human patient is located using in vivo tracked field sensors where in one variation the sensor positions can be located by determining the positions of the sensors relative to a plurality of magnetic field sources of known location. This approach is used, for example, in locating the opening in a renal artery and positioning the proximal end of the AAA stent-graft adjacent to the opening. According to another embodiment, field sensors in combination with signal generators are placed in vivo to locate vasculature aspects. In a further embodiment, an in vivo sensor is positioned in a deployed prosthesis to create a reference for a prosthetic member having a sensor to track to during cannulation of the deployed prosthesis with the prosthetic member.

Abstract: A branch vessel in a human patient is located or mapped using in vivo tracked field sensors where in one variation the sensor positions can be located by determining the positions of the sensors relative to a plurality of magnetic field sources of known location. This approach is used, for example, in locating the opening in a renal artery and positioning the proximal end of the AAA stent-graft adjacent to the opening. In another example, the sensors are tracked along the inner wall of an aneurysm and the acquired sensor location data processed to map the contour of the aneurysm to size a prostheses for spanning the aneurysm. The portions of the vessel adjacent the aneurysm also can be mapped. In a further embodiment, an in vivo sensor is positioned in a deployed prosthesis to create a reference for a prosthetic member having a sensor to track to during cannulation of the deployed prosthesis with the prosthetic member.

Abstract: A method and apparatus for optimizing a computer assisted procedure is provided. A method and apparatus for performing a procedure is also provided. Data can be accessed and processed to optimize and perform a procedure. The data can be augmented or supplemented with patient specific data.