Patents by Inventor Dean Michael Karantonis
Dean Michael Karantonis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944440Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: GrantFiled: August 22, 2022Date of Patent: April 2, 2024Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Peter Scott Vallack Single
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Patent number: 11890113Abstract: A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.Type: GrantFiled: April 8, 2022Date of Patent: February 6, 2024Assignee: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20240033522Abstract: Recording evoked neural responses comprises delivering a stimulus from one or more stimulus electrodes to a neural pathway in order to give rise to an evoked compound action potential (ECAP) on the neural pathway. And, recording with measurement circuitry, during delivery of at least part of the stimulus, a neural compound action potential signal sensed at one or more sense electrodes. And, processing the recording of the neural compound action potential signal to determine at least one characteristic of the ECAP. At least one characteristic of the stimulus is then defined based on the determined at least one characteristic of the ECAP.Type: ApplicationFiled: February 9, 2022Publication date: February 1, 2024Applicant: Saluda Medical Pty LtdInventors: Dean Michael Karantonis, Peter Scott Vallack Single, James Hamilton Wah
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Publication number: 20240024683Abstract: Disclosed is a neurostimulation system comprising: a neuromodulation device for controllably delivering neural stimuli; a headset configured to be worn by the patient and to display images of a virtual object to the patient; one or more sensors configured to perceive a gesture of the patient; and an external computing device. The neuromodulation device comprises: a plurality of implantable electrodes; a stimulus source configured to deliver neural stimuli via selected ones of the implantable electrodes to a neural pathway of a patient; and a control unit configured to control the stimulus source to deliver each neural stimulus according to one or more stimulus parameters. The external computing device comprises a processor in communication with the neuromodulation device, the headset, and the one or more sensors.Type: ApplicationFiled: July 21, 2023Publication date: January 25, 2024Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, Dean Michael Karantonis, Matthew Marlon Williams, Samuel Nicholas Gilbert
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Publication number: 20240017072Abstract: An implantable device comprising: stimulus electrodes and measurement electrodes; a stimulus source to provide a neural stimulus to be delivered to a neural pathway of a patient to evoke a neural response; measurement circuitry configured to capture a signal window sensed on the neural pathway; and a control unit configured to implement closed-loop neurostimulation therapy by: controlling the stimulus source to provide the neural stimulus according to a stimulus intensity parameter; measuring a characteristic of the signal window; computing a feedback variable from an intensity of an evoked neural response in the signal window; adjusting the stimulus intensity parameter using the feedback variable; and repeating the controlling, measuring, computing, and adjusting to maintain the feedback variable at a target, thereby obtaining multiple measured intensities of neural responses; and computing one or more quantitative indicators of efficacy of the closed-loop neurostimulation therapy using the measured characteType: ApplicationFiled: July 13, 2023Publication date: January 18, 2024Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, Matthew Marlon Williams, Daniel John Parker, Dean Michael Karantonis, Samuel Nicholas Gilbert
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Publication number: 20240000367Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.Type: ApplicationFiled: September 14, 2023Publication date: January 4, 2024Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, Dean Michael Karantonis
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Publication number: 20240000358Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: ApplicationFiled: August 22, 2022Publication date: January 4, 2024Inventors: John Louis PARKER, James Hamilton WAH, Dean Michael KARANTONIS, Peter Scott Vallack SINGLE
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Patent number: 11826156Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.Type: GrantFiled: October 25, 2021Date of Patent: November 28, 2023Assignee: Saluda Medical Pty LtdInventors: Dean Michael Karantonis, Peter Scott Vallack Single, Kai Huang
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Patent number: 11819332Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.Type: GrantFiled: December 24, 2019Date of Patent: November 21, 2023Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, Dean Michael Karantonis
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Publication number: 20230355984Abstract: There is provided a method and implantable device for controlling a neural stimulus, the neural stimulus being defined by an artefact mitigation status. The method comprises generating a first neural stimulus for delivery to neural tissue, sensing a first signal subsequent to the first neural stimulus, generating a second neural stimulus for delivery to the neural tissue, and sensing a second signal subsequent to the second neural stimulus. The method further comprises determining an artefact mitigation measure (AMM) effect level based on the first sensed signal and the second sensed signal, and setting, in response to comparing the AMM effect level with an AMM effect threshold, the artefact mitigation status of a third neural stimulus to active.Type: ApplicationFiled: May 9, 2023Publication date: November 9, 2023Applicant: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis, Daniel John Parker, Samuel Nicholas Gilbert
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Publication number: 20230330418Abstract: An implantable device for delivering closed-loop neural stimulation therapy. The device comprises: a plurality of electrodes; a stimulus source to provide neural stimuli via the electrodes to a neural pathway; measurement circuitry to process signals sensed at the electrodes; and a control unit. The control unit is configured to: control the stimulus source to provide a first neural stimulus according to a first stimulus parameter; measure an intensity of a neural response evoked by the first stimulus; compute a feedback variable from the neural response; adjust the first stimulus parameter; repeat the control, measure, compute and adjust to maintain the feedback variable at a target response intensity; control the stimulus source to provide, interleaved with the first neural stimuli, a plurality of second neural stimuli according to respective second stimulus parameters; and monitor the therapy by analysing the sensed signals subsequent to each second neural stimulus.Type: ApplicationFiled: April 14, 2023Publication date: October 19, 2023Applicant: Saluda Medical Pty LtdInventors: Samuel Nicholas Gilbert, Daniel John Parker, Dean Michael Karantonis
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Publication number: 20230321443Abstract: Disclosed is a method of computing a probability distribution of the suitability of measurement electrode configurations for a neuromodulation device. The method comprises: computing the probability distribution of suitability of measurement electrode configurations from: a predetermined stimulus program vector of the neuromodulation device; and prior patient data. Also disclosed is an automated method of setting a measurement electrode configuration for a neuromodulation device configured to deliver a neural stimulus to a neural pathway of a patient.Type: ApplicationFiled: March 22, 2023Publication date: October 12, 2023Applicant: Saluda Medical Pty LtdInventors: Dean Michael Karantonis, Daniel John Parker, Ian Cameron Gould
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Publication number: 20230310870Abstract: An implantable pulse generator device (110) comprising a processor (117) configured to: receive, in a charging mode, electromagnetic radiation (106) from a charging device (102) wherein the electromagnetic radiation (106) transfers energy to the implantable device (110) to charge an energy storage device (104); measure, in a measurement mode, an electrical field parameter signal representing a neural response; and selectively transition between the charging mode and the measurement mode, such that the implantable device (110) does not receive electromagnetic radiation (106) from the charging device (102) during the measurement of the electrical field parameter signal.Type: ApplicationFiled: August 13, 2021Publication date: October 5, 2023Applicant: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20230277852Abstract: Disclosed is an implantable device for controllably delivering a neural stimulus. The device comprises: a plurality of electrodes including one or more stimulus electrodes and one or more sense electrodes; a stimulus source configured to provide a neural stimulus to be delivered via the one or more stimulus electrodes to a neural pathway of a patient in order to evoke a neural response on the neural pathway; measurement circuitry configured to process a signal window sensed at the one or more sense electrodes subsequent to the delivered neural stimulus, the sensed signal window including an evoked neural response; and a control unit.Type: ApplicationFiled: February 14, 2023Publication date: September 7, 2023Applicant: Saluda Medical Pty LtdInventor: Dean Michael Karantonis
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Publication number: 20230277850Abstract: Disclosed is a neuromodulation system comprising a neuromodulation device for controllably delivering a neural stimulus, and a processor.Type: ApplicationFiled: March 3, 2023Publication date: September 7, 2023Applicant: Saluda Medical Pty LtdInventors: Daniel John Parker, James Hamilton Wah, Samuel Nicholas Gilbert, Dean Michael Karantonis, Matthew Marlon Williams, John Louis Parker
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Publication number: 20230241397Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: ApplicationFiled: December 7, 2022Publication date: August 3, 2023Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Publication number: 20230096151Abstract: Disclosed is an implantable device for lead offset determination, comprising first and second electrode leads. A stimulus is delivered from one lead to tissue, and a signal is sensed from the tissue by the other lead. The sensed signal is processed to produce a measure of a stimulus artefact present in the signal. The stimulus artefact measure is used to produce a measure of an offset between the first electrode lead and the second electrode lead, such as by applying a distance-squared. analytical model to measures of stimulus artefact obtained from at least two sense electrodes. And/or, a compound action potential evoked by the stimulus is sensed from neural tissue, a latency of the evoked compound action potential is measured, and a measure of an offset between the first electrode lead and the second electrode lead is produced from the latency.Type: ApplicationFiled: September 28, 2022Publication date: March 30, 2023Applicant: Saluda Medical Pty LimitedInventors: Dean Michael Karantonis, Robert Bruce Gorman, Matthew Marlon Williams, Samuel Nicholas Gilbert, Milan Obradovic
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Publication number: 20230078685Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: ApplicationFiled: August 8, 2022Publication date: March 16, 2023Inventors: Peter Scott Vallack SINGLE, Dean Michael KARANTONIS
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Publication number: 20230014405Abstract: Disclosed is a method of adapting the operation of an implantable device for delivering neurostimulation therapy to a patient. The method comprises: delivering the neurostimulation therapy to electrically excitable tissue of the patient according to at least one therapy parameter; measuring a physiological characteristic of the patient; adjusting the at least one therapy parameter according to a schedule of adjustment and the measured physiological characteristic; and repeating the delivering, measuring, and adjusting.Type: ApplicationFiled: July 15, 2022Publication date: January 19, 2023Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis, Matthew Marlon Williams, Daniel John Parker, Samuel Nicholas Gilbert
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Patent number: 11554265Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: October 29, 2021Date of Patent: January 17, 2023Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman