Patents by Inventor Dean Michael Karantonis
Dean Michael Karantonis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11491334Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: September 24, 2020Date of Patent: November 8, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11464980Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: GrantFiled: April 20, 2022Date of Patent: October 11, 2022Assignee: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 11464979Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: September 29, 2021Date of Patent: October 11, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11445958Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: GrantFiled: June 22, 2021Date of Patent: September 20, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Peter Scott Vallack Single
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Patent number: 11439828Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: October 14, 2021Date of Patent: September 13, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Laird-Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11426587Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: January 14, 2022Date of Patent: August 30, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11420064Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: September 17, 2021Date of Patent: August 23, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11413460Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: GrantFiled: March 14, 2022Date of Patent: August 16, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Publication number: 20220249848Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: ApplicationFiled: April 20, 2022Publication date: August 11, 2022Inventors: Peter Scott Vallack SINGLE, Dean Michael KARANTONIS
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Publication number: 20220248999Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: ApplicationFiled: April 26, 2022Publication date: August 11, 2022Inventors: John Louis PARKER, Peter Scott Vallack SINGLE, Dean Michael KARANTONIS
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Publication number: 20220233150Abstract: A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.Type: ApplicationFiled: April 8, 2022Publication date: July 28, 2022Inventors: Peter Scott Vallack SINGLE, Dean Michael KARANTONIS
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Publication number: 20220193416Abstract: A method of applying a neural stimulus with an implanted electrode array involves applying a sequence of stimuli configured to yield a therapeutic effect while suppressing psychophysical side effects. The stimuli sequence is configured such that a first stimulus recruits a portion of the fibre population, and a second stimulus is delivered within the refractory period following the first stimulus and the second stimulus being configured to recruit a further portion of the fibre population. Using an electrode array and suitable relative timing of the stimuli, ascending or descending volleys of evoked responses can be selectively synchronised or desynchronised to give directional control over responses evoked.Type: ApplicationFiled: March 14, 2022Publication date: June 23, 2022Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Patent number: 11344729Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: GrantFiled: November 22, 2021Date of Patent: May 31, 2022Assignee: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 11337658Abstract: A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.Type: GrantFiled: August 9, 2019Date of Patent: May 24, 2022Assignee: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20220151536Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.Type: ApplicationFiled: October 25, 2021Publication date: May 19, 2022Applicant: Saluda Medical Pty LtdInventors: Dean Michael Karantonis, Peter Scott Vallack Single, Kai Huang
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Publication number: 20220152398Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: ApplicationFiled: November 22, 2021Publication date: May 19, 2022Inventors: Peter Scott Vallack SINGLE, Dean Michael KARANTONIS
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Patent number: 11324427Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: GrantFiled: April 22, 2019Date of Patent: May 10, 2022Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 11219766Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.Type: GrantFiled: October 30, 2019Date of Patent: January 11, 2022Assignee: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20210393964Abstract: A neurostimulation device has a stimulus, and a position of a measurement electrode relative to the stimulus, configured such that in artefact as arising relative to distance from the stimulus electrode a minima region of the artefact is substantially co-located with the measurement electrode. Or, a ratio of the inter-electrode spacing to the electrode length is between 2 and 3.66. Or, an impedance is connected to a passive electrode and is configured to reduce artefact arising on the measurement electrode.Type: ApplicationFiled: October 23, 2019Publication date: December 23, 2021Applicant: Saluda Medical Pty LtdInventors: Peter Scott Vallack Single, Dean Michael Karantonis, Jonathan Brereton Scott
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Patent number: 11179091Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.Type: GrantFiled: June 23, 2017Date of Patent: November 23, 2021Assignee: Saluda Medical Pty LtdInventors: Dean Michael Karantonis, Peter Scott Vallack Single, Kai Huang