Patents by Inventor Dean Michael Karantonis
Dean Michael Karantonis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210315502Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: ApplicationFiled: June 22, 2021Publication date: October 14, 2021Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis
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Patent number: 11045129Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: GrantFiled: March 21, 2018Date of Patent: June 29, 2021Assignee: Saluda Medical Pty Ltd.Inventors: John Louis Parker, James Hamilton Wah, Dean Michael Karantonis
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Publication number: 20210001133Abstract: A system for managing clinical data of an implanted neuromodulation device. An implanted neuromodulation device delivers electrical neurostimulation therapy, and captures recordings of neural responses to the electrical neurostimulation therapy. The device communicates clinical data including recordings of the neural responses to a non-implanted receiver. A supervisory device receives clinical data from the implanted neuromodulation device via the receiver, and presents the clinical data for review by a reviewer.Type: ApplicationFiled: March 23, 2018Publication date: January 7, 2021Applicant: Saluda Medical Pty LtdInventors: Matthew Marlon Williams, Dean Michael Karantonis, Ivan Guelton, Robert Bruce Gorman
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Publication number: 20200129108Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.Type: ApplicationFiled: December 24, 2019Publication date: April 30, 2020Applicant: Saluda Medical Pty LtdInventors: John Louis Parker, Dean Michael Karantonis
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Patent number: 10568559Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.Type: GrantFiled: May 11, 2012Date of Patent: February 25, 2020Assignee: Saluda Medical Pty LtdInventors: John Louis Parker, Dean Michael Karantonis
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Publication number: 20190307341Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: ApplicationFiled: April 22, 2019Publication date: October 10, 2019Applicant: Saluda Medical Pty Ltd.Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 10278600Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: GrantFiled: June 16, 2016Date of Patent: May 7, 2019Assignee: Saluda Medical Pty Ltd.Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20180256052Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: ApplicationFiled: March 21, 2018Publication date: September 13, 2018Applicant: Saluda Medical Pty. Ltd.Inventors: John Louis Parker, James Hamilton Laird, Dean Michael Karantonis
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Patent number: 9974455Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse Width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: GrantFiled: May 11, 2012Date of Patent: May 22, 2018Assignee: Saluda Medical Pty Ltd.Inventors: John Louis Parker, James Hamilton Laird, Dean Michael Karantonis
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Publication number: 20170071490Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: ApplicationFiled: June 16, 2016Publication date: March 16, 2017Applicant: Saluda Medical Pty, Ltd.Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 9386934Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: GrantFiled: May 11, 2012Date of Patent: July 12, 2016Assignee: Saluda Medical Pty Ltd.Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Patent number: 9381356Abstract: An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.Type: GrantFiled: May 11, 2012Date of Patent: July 5, 2016Assignee: Saluda Medical Pty Ltd.Inventors: John Louis Parker, James Hamilton Laird, Dean Michael Karantonis, Milan Obradovic, Robert Bruce Gorman
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Publication number: 20150164354Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.Type: ApplicationFiled: May 11, 2012Publication date: June 18, 2015Inventors: John Louis Parker, Peter Scott Vallack Single, Dean Michael Karantonis
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Publication number: 20140296737Abstract: A method for determining a desired location at which to apply a neural therapy. An array of electrodes is positioned proximal to neural tissue. A stimulus is applied from the array which evokes a neural compound action potential response in the neural tissue proximal to the array. A plurality of electrodes of the array simultaneously obtain respective measurements of the neural compound action potential response. From the measurements of the neural compound action potential response a desired location for a neural therapy is determined.Type: ApplicationFiled: May 11, 2012Publication date: October 2, 2014Inventors: John Louis Parker, Dean Michael Karantonis
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Publication number: 20140236257Abstract: An implantable device applies and controls a neural stimulus. The device has a plurality of electrodes, and a stimulus source for providing a stimulus to be delivered from the electrodes to a neural pathway in order to evoke an action potential on the neural pathway, such as the spinal cord. A control unit controls application of a neural stimulus as defined by a set of parameter values and measures via measurement circuitry an evoked neural compound action potential response. The control unit determines from the measured evoked response a feedback variable, and compares it to a therapy map. The therapy map defines a therapeutic relationship of control variable to feedback variable. One or more of the stimulus parameter values are altered to effect the required change in the control variable. This process is performed iteratively to improve alignment of the feedback variable with the therapy map over time.Type: ApplicationFiled: May 11, 2012Publication date: August 21, 2014Applicant: Saluda Medical Pty. Ltd.Inventors: John Louis Parker, James Hamilton Laird, Dean Michael Karantonis, Milan Obradovic
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Publication number: 20140236042Abstract: A method for estimating conduction velocity of a neural response. Measurements of the neural response are obtained from at least two electrodes which are at distinct locations along a neural pathway. A delay between the time of arrival of the neural response at each respective electrode is determined from the measurements. From the delay, and from knowledge of electrode spacing, a conduction velocity of the neural response is estimated.Type: ApplicationFiled: May 11, 2012Publication date: August 21, 2014Applicant: Saluda Medical Pty. Ltd.Inventors: John Louis Parker, Dean Michael Karantonis
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Publication number: 20140194771Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.Type: ApplicationFiled: May 11, 2012Publication date: July 10, 2014Inventors: John Louis Parker, James Hamilton Laird, Dean Michael Karantonis