Patents by Inventor Deep Arjun Singh
Deep Arjun Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20190344046Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: July 26, 2019Publication date: November 14, 2019Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
-
Patent number: 10456533Abstract: Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.Type: GrantFiled: June 17, 2014Date of Patent: October 29, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, P J Anand
-
Publication number: 20190314574Abstract: Percutaneous therapy or drug delivery devices are described herein. The device can include one or multiple lumens inside a cannula or catheter body. The device can include features for reducing or preventing backflow or reflux of infusate along the device insertion track, such as one or more bullet noses, over tubes, and/or micro-tips. The device can be used in any of a variety of treatment methods, including to inject cancer therapy medicinal products directly into pulmonary tumors or tumors located in other regions of the body. The device can include features to keep the distal tip secure during patient respiration or during other patient movement, and can reduce the incidence of reflux during therapy delivery.Type: ApplicationFiled: February 27, 2019Publication date: October 17, 2019Inventors: Katelyn Perkins-Neaton, Gregory Eberl, Morgan Brophy, Andrew East, PJ Anand, Deep Arjun Singh, Loredana Guseila, Jon Freund, Derek Peter
-
Patent number: 10441770Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.Type: GrantFiled: July 31, 2014Date of Patent: October 15, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Andrew East
-
Patent number: 10434251Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.Type: GrantFiled: August 1, 2012Date of Patent: October 8, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh
-
Patent number: 10406285Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: GrantFiled: May 25, 2017Date of Patent: September 10, 2019Assignee: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
-
Publication number: 20190255284Abstract: Catheters, catheter ports, connectors, and related methods are disclosed herein, e.g., for drug delivery to a subject. The catheters and catheter ports can include various features to facilitate dosing protocols that require multiple injections, and/or for reducing or eliminating damage that may occur to the catheter, port, or patient tissue as a result of multiple injections.Type: ApplicationFiled: February 21, 2019Publication date: August 22, 2019Inventors: Jonathan Freund, PJ Anand, Deep Arjun Singh, Gregory Eberl
-
Patent number: 10363394Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: September 20, 2017Date of Patent: July 30, 2019Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, P J Anand, Blake Sama
-
Publication number: 20190160254Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: November 15, 2018Publication date: May 30, 2019Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura, Andrew East, Jonathan Freund
-
Publication number: 20190143038Abstract: A therapy specific, pre-programmed, hand-held auto-injection device for delivering a drug to a patient includes a housing, a plurality of syringes carried by the housing, at least one actuator disposed within the housing coupled to the plurality of syringes, and a controller disposed within the housing and communicatively coupled to the at least one actuator. The controller is configured to receive an infusion and aspiration profile, which includes an infusion and aspiration protocol for controlling at least one of the plurality of syringes. The controller is also configured to operate the at least one actuator based on the infusion and aspiration protocol by either expelling a fluid from a respective barrel of the plurality of syringes into the infusion and aspiration location or drawing a fluid from the infusion and aspiration location into a respectively barrel of the plurality of syringes.Type: ApplicationFiled: November 14, 2018Publication date: May 16, 2019Inventors: Pj Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
-
Publication number: 20190143037Abstract: A method of delivering a drug to a patient using a therapy specific, pre-programmed auto-injection device includes positioning the hand-held device proximate to an infusion and aspiration location of the patient, and receiving, at a controller disposed within the housing, an infusion and aspiration profile. The infusion and aspiration profile including an infusion and aspiration protocol for controlling at least one of a plurality of syringes partially disposed within the housing. The method also includes operating at least one actuator coupled to the plurality of syringes according to the infusion and aspiration protocol, causing the syringes to expel a fluid from a respective barrel of the plurality of syringe into the infusion and aspiration location or causing the syringes to draw a fluid from the infusion and aspiration location into a respective barrel of the plurality of syringes.Type: ApplicationFiled: November 14, 2018Publication date: May 16, 2019Inventors: PJ Anand, Deep Arjun Singh, Jonathan Freund, Katelyn Perkins-Neaton, Thomas T. Washburn
-
Publication number: 20190009055Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: August 31, 2018Publication date: January 10, 2019Applicant: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
-
Patent number: 10065016Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: January 21, 2015Date of Patent: September 4, 2018Assignee: ALCYONE LIFESCIENCES, INC.Inventors: Deep Arjun Singh, Pj Anand, Blake Sama
-
Publication number: 20180193595Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: September 20, 2017Publication date: July 12, 2018Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
-
Publication number: 20180185058Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: December 21, 2017Publication date: July 5, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura
-
Publication number: 20180104459Abstract: Systems and methods for flushing shunt systems are disclosed herein. In some embodiments, a flusher includes a pinch tube that extends over a flush dome such that a user can simultaneously close the pinch tube and actuate the flush dome with a single motion. Flushing and refill valves of the system can be disposed in a cartridge that is laterally-offset from the flush dome, advantageously reducing the height profile of the flusher. Flushers with integrated shunt valves are also disclosed, as are shunt systems with restricted and unrestricted modes for selectively limiting the instances in which a user can open an auxiliary flow path through the system.Type: ApplicationFiled: October 12, 2017Publication date: April 19, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh, Greg Eberl, Andrew East, Morgan Brophy, Ayesha Arzumand, Stela Moura, Loredana Guseila
-
Patent number: 9919129Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: December 18, 2013Date of Patent: March 20, 2018Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Blake Sama
-
Publication number: 20180064919Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: July 20, 2017Publication date: March 8, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
-
Publication number: 20180028761Abstract: Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.Type: ApplicationFiled: July 28, 2017Publication date: February 1, 2018Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Ayesha Arzumand, Morgan Brophy, Andrew East, Gregory Eberl, Deep Arjun Singh
-
Publication number: 20170258996Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: May 25, 2017Publication date: September 14, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl