Patents by Inventor Deep Arjun Singh
Deep Arjun Singh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9744338Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: April 18, 2015Date of Patent: August 29, 2017Assignee: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, P J Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20170189040Abstract: Methods and devices are disclosed herein that allow for infusion and aspiration through a single device. The device can be used to treat a stroke by delivering the device to the site of a blood clot and simultaneously or sequentially infusing a thrombolytic or other drug into the clot and aspirating the dissolving clot from the patient. The methods and devices can advantageously permit more efficient thrombolytic infusion and clot aspiration. Modular systems are also disclosed, as are methods of treating subdural hematoma or other conditions.Type: ApplicationFiled: January 4, 2017Publication date: July 6, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, John Ekholm, Deep Arjun Singh
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Publication number: 20170189656Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: March 17, 2017Publication date: July 6, 2017Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Deep Arjun Singh, Morgan Brophy, Timothy Fallon, Robert Degon, Matthew Attar, Anthony Wong, Allison Waller, Andrew East, Jon T. McIntyre
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Patent number: 9682193Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: GrantFiled: May 11, 2016Date of Patent: June 20, 2017Assignee: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Patent number: 9629987Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: January 22, 2014Date of Patent: April 25, 2017Assignee: Alcoyne Lifesciences, Inc.Inventors: P J Anand, Deep Arjun Singh, Morgan Brophy, Timothy Fallon, Robert Degon, Matthew Attar, Anthony Wong, Allison Waller, Andrew East, Jon T. McIntyre
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Publication number: 20160331897Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.Type: ApplicationFiled: May 11, 2016Publication date: November 17, 2016Applicant: Alcyone Lifesciences, Inc.Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl
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Patent number: 9433764Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: GrantFiled: June 16, 2015Date of Patent: September 6, 2016Assignee: Alcyone Lifesciences, Inc.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20160213312Abstract: Systems and methods for delivering a drug with a tracer or contrast agent are disclosed herein, as are systems and methods that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: January 26, 2015Publication date: July 28, 2016Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Deep Arjun Singh, PJ Anand, Martin Lee Brady
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Publication number: 20150367110Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: June 16, 2015Publication date: December 24, 2015Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20150297874Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: April 18, 2015Publication date: October 22, 2015Applicant: ALCYONE LIFESCIENCES, INC.Inventors: Andrew East, Morgan Brophy, Deep Arjun Singh, PJ Anand, Robert Degon, Timothy Fallon, Allison Waller, Matthew Attar
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Publication number: 20150133887Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: January 21, 2015Publication date: May 14, 2015Inventors: Deep Arjun Singh, PJ Anand
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Patent number: 8992458Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: GrantFiled: December 18, 2013Date of Patent: March 31, 2015Assignee: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20150038949Abstract: Systems and methods for delivering a drug or other therapy over an extended period of time (e.g., several hours, days, weeks, months, years, and so forth) are disclosed herein, as are systems and methods for monitoring various parameters associated with the treatment of a patient. Systems and methods are also disclosed herein that generally involve CED devices with various features for reducing or preventing backflow.Type: ApplicationFiled: July 31, 2014Publication date: February 5, 2015Applicant: Alcyone Lifesciences, Inc.Inventors: Deep Arjun Singh, PJ Anand, Andrew East
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Publication number: 20140371711Abstract: Methods and devices are disclosed herein that generally provide protection for devices (e.g., microcatheters) having small tips. Methods and devices are also disclosed herein that generally facilitate use of commercially-available stereotactic systems with devices (e.g., microcatheters) having small tips.Type: ApplicationFiled: June 17, 2014Publication date: December 18, 2014Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20140207045Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: January 22, 2014Publication date: July 24, 2014Applicant: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh, Morgan Brophy, Timothy Fallon, Robert Degon, Matthew Attar, Anthony Wong, Allison Waller, Andrew East, Jon T. McIntyre
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Publication number: 20140207043Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked.Type: ApplicationFiled: January 22, 2014Publication date: July 24, 2014Applicant: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh
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Publication number: 20140171902Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: December 18, 2013Publication date: June 19, 2014Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20140171760Abstract: Systems and methods are disclosed herein that generally involve CED devices with various features for reducing or preventing backflow. In some embodiments, CED devices include a tissue-receiving space disposed proximal to a distal fluid outlet. Tissue can be compressed into or pinched/pinned by the tissue-receiving space as the device is inserted into a target region of a patient, thereby forming a seal that reduces or prevents proximal backflow of fluid ejected from the outlet beyond the tissue-receiving space. In some embodiments, CED devices include a bullet-shaped nose proximal to a distal fluid outlet. The bullet-shaped nose forms a good seal with surrounding tissue and helps reduce or prevent backflow of infused fluid.Type: ApplicationFiled: December 18, 2013Publication date: June 19, 2014Inventors: Deep Arjun Singh, PJ Anand
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Publication number: 20130035560Abstract: The methods, systems, and devices disclosed herein generally involve convection-enhanced delivery of drugs to a target region within a patient. Microfluidic catheter devices are disclosed that are particularly suitable for targeted delivery of drugs via convection, including devices capable of multi-directional drug delivery, devices that control fluid pressure and velocity using the venturi effect, and devices that include conformable balloons. Methods of treating various diseases using such devices are also disclosed, including methods of treating cerebral and spinal cavernous malformations, cavernomas, and hemangiomas, methods of treating neurological diseases, methods of treatment using multiple microfluidic delivery devices, methods of treating hearing disorders, methods of spinal drug delivery using microfluidic devices, and methods of delivering stem cells and therapeutics during fetal surgery. Methods of manufacturing such devices are also disclosed.Type: ApplicationFiled: August 1, 2012Publication date: February 7, 2013Applicant: ALCYONE LIFESCIENCES, INC.Inventors: PJ Anand, Deep Arjun Singh