Abstract: A device includes an elongated hollow member having an open distal end for receiving tissue therein and at least one exterior groove for loading at least one ligation band thereon. The device also includes a band deployment sleeve slidable over the exterior of the hollow member and configured to move from a radially expanded position to a radially contracted position in which, when the band deployment sleeve slides longitudinally over the hollow member, the distal portion engages the at least one ligation band. A closing sleeve slidable over the exterior of the band deployment sleeve is configured to constrain the distal portion from the radially expanded position into the radially contracted position. Retracting the closing sleeve proximally over the distal portion of the band deployment sleeve releases the distal portion from the radially contracted position into the radially expanded position.

Abstract: A medical device is adapted to seal around elongate shafts of varying diameter therethrough. The medical device includes a plurality of elastomeric sealing members together defining a variable dimension aperture, a chuck body, and a chuck ring that is rotatably secured relative to the chuck body. The medical device is adapted such that rotating the chuck ring in a first direction causes the plurality of elastomeric sealing members to move closer together, thereby reducing a size of the variable dimension aperture, and rotating the chuck ring in a second direction causes the plurality of elastomeric sealing members to move farther apart, thereby increasing a size of the variable dimension aperture.

Abstract: The present invention provides a novel peptide as potent inhibitor of protein aggregation. A peptide for an inhibition of protein aggregation having the general Formula 1, [XiSACX1]mHHHH[X2X3CGG]m is provided. The m is 0 or 1; Xi is an acetyl group; X1 is a hydrophilic polar uncharged amide group containing amino acid; X2 is His or Leu; and X3 is His or Ser. The present invention specifically relates to peptide-based inhibitors useful in treatment of amyloid related disorders.

Abstract: A clipping system includes an adapter, a clip and an extending member. The adapter mounted over an insertion device. The clip mounted over the adapter and includes first and second jaws connected to one another such that the jaws are movable between an insertion configuration and an initial deployed configuration. The first jaw includes a keyhole opening. The member coupled to the clip and adapter. The member includes a distal end releasably engaging the opening. The distal end has a width smaller than a width of a first portion of the opening and larger than a second portion of the opening so that, when a portion of the member proximal of the distal end is received within the second portion, the adapter is released from the clip while the member remains coupled to the clip. The member forces the clip open as the clip retracts over the adapter.

Abstract: A medical device may comprise a shaft, an articulation wire extending through at least a portion of the shaft, and a handle, including a handle body having an outer surface that defines a channel. A distal portion of the shaft may be received within a first portion of the channel. A distal portion of the articulation wire may be received within a second portion of the channel. A control member may be movable relative to the handle body to move the distal portion of the articulation wire relative to the distal portion of the shaft.

Abstract: A system includes an adapter mounted over a distal end of an insertion device and an extending member. A clip mounted over the adapter includes jaws movable to separate from one another and, when the clip is moved off the adapter, to draw toward one another. The first member is releasably coupled to the clip, movably connected to the adapter and includes a clasp releasably coupling the clip to the first member via an engaging portion of one jaw to permit movement of the adapter relative to the clip while the first member remains coupled to the clip, enhancing visualization of the clip. The first member is operable to retract the clip proximally over the adapter so that the clip is forced open as the clip is retracted over the adapter freeing the clip from tissue on which it had been clipped.

Abstract: An elongate steerable medical device includes a shaft and a handle assembly that is removably securable to the shaft. The shaft includes an elongate outer member and an elongate inner member that is disposed within the elongate outer member. The handle assembly includes a proximal handle, a spool that is slidingly secured to the handle body and a collet that is removably secured to the handle body. The spool is adapted to releasable secure the elongate inner member and the collet is adapted to releasably secure the elongate outer member.

Abstract: A system includes an adapter mounted over a distal end of an insertion device, a clip and a first extending member. The clip includes jaws movable between an insertion configuration, with the jaws separated and an initial deployed configuration with the jaws drawn together. The clip is biased toward the initial configuration. The first jaw includes a connection element and a first member releasably coupled to the first jaw connection element permits movement of the adapter relative to the clip while the first member remains coupled to the clip to enhance visual observation of the clip. The first member retracts the clip proximally over the adapter so that the clip is forced open as the clip is retracted over the adapter freeing the clip from tissue on which it had been clipped.

Abstract: A system for treating tissue includes a cap mounted over a distal end of an endoscope, a clip mountable over the cap and including first and second jaws movably connected to one another between an insertion configuration, in which the first and second jaws extend over the cap to receive a target tissue therebetween, a review configuration, in which at least a portion of the clip extends into a field of view of the optical system of an endoscope, and a deployed configuration in which the clip is moved distally off of the cap so that the first and second jaws are drawn toward one another. A control element is configured so that movement proximally through the cap via a first distance moves the clip from the insertion configuration to the review configuration and a second distance moves the clip from the review configuration to the deployed configuration.

Abstract: A device includes an anoscope including an elongated hollow member with a longitudinal slot configured to receive tissue in an interior of the hollow member. The device also includes a clip applicator. The clip applicator includes a body slidably received in the slot and jaws at a distal end of the body configured to hold a ligation clip. The clip applicator further includes a plunger slidably coupled to the body configured to actuate the jaws. When the clip applicator is inserted into the slot and the plunger is moved relative to the body, the jaws close and deform the ligation clip from an open position into a closed position around tissue received in the slot.

Abstract: A medical device is adapted for use in assisting with mechanical thrombectomy. The medical device may include a housing that is adapted to be held within a user's hand and a pump that is secured within the housing. A fluid inlet is adapted to receive fluid that is pulled towards the pump and is fluidly coupled with the pump. A fluid outlet is adapted to expel fluid away from the pump and is fluidly coupled with the pump. As the pump is operated by the user, fluid is alternatively pulled into the fluid inlet and expelled through the fluid outlet. In some cases, the fluid may be blood or other bodily fluids.

Abstract: A suction device configured to simultaneously draw in fluid and expel fluid. The suction device may comprise a barrel defining a cavity and extending from a first end to a second end. A first fluid inlet may be adjacent the first end of the barrel and a second fluid inlet adjacent the second end of the barrel and a first fluid outlet may be adjacent the first end of the barrel and a second fluid outlet adjacent the second end of the barrel. A plunger may be slideably disposed within the cavity of the barrel with a handle assembly operably coupled thereto. A actuation of the handle assembly may be configured to move the plunger within the cavity between the first end and the second end of the barrel.

Abstract: A clipping system includes a cap configured to be mounted over a distal end of an endoscope. A clip mountable over the cap to move between an insertion configuration, in which first and second jaws extend over opposing portions of the cap so that the first and second jaws are separated from one another, a review configuration, in which the clip is moved distally relative to the cap so that a portion of the clip extends distally until at least a portion of the clip extends into a field of view of the optical system of an endoscope on which the cap is mounted, and a deployed configuration in which the clip is moved distally off of the clip so that the first and second jaws are drawn toward one another under the bias of the at least one hinge to close over tissue received therebetween.

Abstract: A medical device comprising a handle, a shaft extending from the handle, and an inflatable module at a distal portion of the shaft, the module including a camera, wherein the shaft includes a body defining a first channel extending between a first end configured to be in fluid communication with a fluid source, and a second end in fluid communication with the module, and wherein inflation of the module alters a viewing angle of the camera relative to an axis of the distal portion of the shaft.

Abstract: A medical system includes a medical device and an end cap. The medical device includes a handle, including an actuation device, and a shaft extending from the handle. A distal end of the shaft includes a tab, and the tab is movable based on movement of the actuation device. The end cap includes a modular camera assembly. The modular camera assembly includes a camera, a support, an arm, and a cavity. The tab is coupleable to the modular camera assembly via the cavity, and movement of the tab controls a position of the support and the camera.

Abstract: A medical device having multiple degrees of freedom independent of each other. The medical device includes a handle, an end effector, and a tubular section extending between the handle and the end effector. The end effector is configured to be rotated about a first axis extending through the tubular section without rotating the tubular section. And, the tubular section is configured to be rotated about the first axis with the end effector.

Abstract: A medical device system includes an insertion device and a medical device. The insertion device includes an insertion device handle, including a port on a handle body. The insertion device also includes an insertion device shaft extending from the insertion device handle. The insertion device shaft includes a working channel connected to the port. The medical device includes a medical device handle, including a movable handle portion and a stationary handle portion. The movable handle portion includes a ball portion movably positioned within a cavity in the stationary handle portion. The medical device also includes a medical device shaft. The medical device shaft is configured to be delivered through the port in the insertion device handle and through the working channel in the insertion device shaft. Movement of the movable handle portion relative to the stationary handle portion controls movement of a distal portion of the medical device shaft.

Abstract: A medical device for insertion into a body may include a handle assembly including a handle body and a ball joint; a sensor assembly configured to electronically communicate with a magnet; a body extending longitudinally from the handle assembly; an articulation portion coupled to a distal end of the body, wherein the articulation portion includes a magnetic material; and an end effector coupled to a distal end of the articulation portion. The articulation portion may be configured to move upon application of a magnetic field from the magnet.

Abstract: A medical device may comprise a handle having at least one actuator, a shaft having a proximal end and a distal end, the proximal end connected to the handle, and a distal assembly connected to the distal end of the shaft, the distal assembly including an end effector. The handle may be configured so that a single hand of a user can operate the at least one actuator to (1) actuate the end effector, (2) rotate the end effector relative to the shaft, and (3) articulate a distal portion of the shaft.

Abstract: A medical device includes a handle including a first slot, a first control device movable within the first slot in a proximal direction and a distal direction, and a sheath extending from the handle and having a longitudinal axis, the sheath defining a first lumen extending from the handle to a distal end of the sheath. A first tube extends within the first lumen, the first tube is connected to the first control device and moves between a first position, where a distalmost end of the first tube is flush with or proximal of a distalmost end of the sheath, and a second position, where the distalmost end of the first tube is positioned distal of the distalmost end of the sheath. The first slot extends parallel to the longitudinal direction of the sheath.