Abstract: A medical device comprising a handle extending between a first end and a second end, a first actuator coupled to the first end of the handle, a first shaft coupled to the second end of the handle, and a second shaft extending from the first shaft, the second shaft including a first articulation section and a second articulation section, wherein an articulation of the first actuator relative to the handle is configured to articulate the first articulation section, an articulation of the handle relative to the first shaft is configured to articulate the second articulation section, and the first articulation section and the second articulation section are restricted to articulating only in a first plane.

Abstract: A clipping system includes an adapter configured to be mounted over an insertion device and a clip including first and second jaws movable between an insertion configuration and an initial deployed configuration. A first extending member is releasably coupled to the clip and movably connected to the adapter to permit a movement of the clip relative to the adapter from the insertion configuration to the initial deployed configuration. The first extending member is configured to permit withdrawal of the adapter away from the clip to place the system in a review configuration to enhance a visual observation of the clip. The first extending member is operable to retract the clip over the adapter so that the clip is forced open, freeing the clip from tissue on which it has been clipped. The first extending member is configured to release the clip therefrom in a final deployed configuration.

Abstract: A clipping system includes an adapter mounted on an insertion device and a clip including first and second jaws connected via hinges so that the first and second jaws are movable between an insertion configuration and an initial deployed configuration. A deployment member is configured to move the clip distally over and off of the adapter so that, as the clip leaves the adapter, the clip moves from the insertion configuration to the initial deployed configuration. An extending member is releasably coupled to the clip and movably connected to the adapter, and is configured to permit the withdrawal of the adapter away from the clip while the extending member remains coupled to the clip to place the system in a review configuration. The extending member is operable to retract the clip over the adapter, freeing the clip from tissue on which it had been clipped.

Abstract: A tissue-engagement member having a pair of jaws movable between a closed configuration and an open configuration, an actuator movable to shift the jaws between the closed and open configurations, and a biasing element biasing the jaws into a closed configuration. The biasing element may be provided over a portion of the tissue-engagement member. A cam mechanism may be provided in operative association with at least one of the jaws and/or the actuator. The biasing element may operatively engage at least one of the jaws and/or the actuator to actuate the cam mechanism to return the jaws to a closed configuration from an open configuration. A manipulator having an actuator-engagement element may be provided to engage an actuation element operatively associated with the actuator. The actuator-engagement element may operatively engage the actuation element in a range of orientations.

Abstract: The current invention relates to recombinant vectors for high protein expression. More particularly, it relates to recombinant vector having promoter sequence and terminator sequence for constitutive expression of homologous and heterologous proteins wherein the promoter sequence is selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2 and terminator sequence having sequence selected from the group consisting of SEQ ID NO: 3 and SEQ ID NO: 4.

Abstract: In one example, a medical device may include a main shaft extending from a proximal end to a distal end; a first articulation shaft coupled to the distal end of the main shaft; a second articulation shaft coupled to a distal end of the first articulation shaft; a first articulation wire coupled proximate to a distal portion of the first articulation shaft and extending longitudinally through the main shaft and the first articulation shaft; and a second articulation wire coupled proximate to a distal portion of the second articulation shaft and extending longitudinally through the main shaft, the first articulation shaft, and the second articulation shaft.

Abstract: A medical device that includes a handle, a shaft extending distally from the handle, an end effector extending distally from the shaft, and a first actuator coupled to the handle and secured to a first wire. The first wire extends through the shaft, and the first actuator is configured to pivot relative to the shaft to pull the first wire proximally and to deflect the end effector relative to the shaft.

Abstract: A medical device includes a handle, a shaft extending from the handle, and an articulation member integral with or attached to a distal end of the shaft. The articulation member includes a first portion coupled to a second portion, the second portion is receivable in a slot defined by the first portion, and the handle is coupled to each of the first portion and the second portion and to articulate the first portion independently of articulating the second portion.

Abstract: A medical device that includes a handle, an actuator movably coupled to the handle, a shaft extending distally from the handle, and a sheath including a distal end disposed within the shaft and a proximal end disposed within the handle. The sheath includes a plurality of branches secured to one another at the distal end and separated from one another at the proximal end. The actuator is coupled to each of the plurality of branches at the proximal end of the sheath, and the actuator is configured to move each of the plurality of branches relative to one another to articulate the shaft in a plurality of directions.

Abstract: A medical device that includes a handle, a shaft extending distally from the handle, an end effector extending distally from the shaft, a first actuator movably coupled to the handle, and a second actuator movably coupled to the handle. The first actuator is configured to (1) articulate the shaft in response to translating the first actuator in a first direction relative to the handle and the second actuator, and (2) actuate the end effector in response to translating the first actuator in a second direction relative to the handle and the second actuator. The second actuator is configured to (1) articulate the shaft in response to translating the second actuator in the first direction relative to the handle and the first actuator, and (2) actuate the end effector in response to translating the second actuator in the second direction relative to the handle and the first actuator.

Abstract: A medical device, for example a delivery catheter, may include a handle portion, a shaft portion extending distally from the handle portion, a deployment mechanism, and an actuation member positioned on the handle portion. The shaft portion may include a working channel and a distal tip portion having a payload chamber configured to receive a payload, such as a bio-absorbable foam. The distal tip portion may be operatively connected to the working channel. The deployment mechanism may be positioned in the working channel, and may be operable to deploy the payload out from the distal tip portion. The actuation member may be actuatable to operate the deployment mechanism.

Abstract: A medical device that includes a handle, a shaft extending distally from the handle and defining a lumen, and an actuator disposed in the shaft and including a distal tip. The actuator and the distal tip are movable relative to the lumen. The medical device includes an expandable member having an inner cavity. The actuator is configured to engage the expandable member when moving distally relative to the lumen and in response to the distal tip entering the inner cavity. The actuator is configured to disengage the expandable member when moving proximally relative to the lumen and in response to the distal tip exiting the inner cavity.

Abstract: A medical device, comprising a tube including at least one lumen, an absorbent located at a distal portion of the tube, the absorbent being configured to transition from a compressed state to an expanded state, and a structure fixed to the absorbent, wherein the structure is configured to flex into a compressed state and an expanded state simultaneously with the compressed state and the expanded state of the absorbent, and the structure exposes at least a portion of the absorbent.

Abstract: A medical device that includes a body and an arm extending from the body and configured to receive a first device such that the first device is suspended relative to the body. Translation of the arm relative to the body is configured to move the first device relative to the body. The medical device includes a receiver extending from the body and configured to receive a second device such that the second device is suspended relative to the body.

Abstract: A medical device may include a handle including a fixed body and a movable body. The movable body may be movable relative to the fixed body. The medical device may include a shaft extending from the fixed body and an end effector at a distal end of the shaft. Rotation of the movable body relative to the fixed body may permit rotation of the end effector relative to the shaft, and rotation of the movable body with rotation of the fixed body may permit rotation of the end effector with the shaft. Deflection of the movable body relative to the fixed body may permit deflection of the end effector relative to the fixed body.

Abstract: A medical device that includes a handle including a plurality of actuators. The handle defines a longitudinal axis extending through a distal end of the handle. The device includes a shaft extending from the handle and an end effector at a distal end of the shaft. A first actuator of the plurality of actuators is configured to actuate the end effector in response to translation of the first actuator relative to the handle along an axis parallel to the longitudinal axis. A second actuator of the plurality of actuators is configured to deflect the end effector relative to the shaft in response to pivoting the second actuator about an axis transverse to the longitudinal axis. A third actuator of the plurality of actuators is configured to rotate the end effector relative to the shaft in response to rotation of the third actuator relative to the handle about the longitudinal axis.

Abstract: A biopsy forceps device includes a control member; a yoke coupled to the member; jaws coupled to the yoke; and a capsule. In an open configuration, the jaws are separated to receive target tissue. In a closed configuration, cutting edges of the jaws are moved toward one another to cut tissue. The capsule slidably receives the yoke and a portion of the jaws. The jaws are constrained to the closed configuration when withdrawn proximally to a first position within the capsule. When the jaws are moved to a second position, portions of the jaws are freed from the constraint capsule and spread apart. When the yoke and the jaws are moved distally and the jaws move to the open configuration, a tissue contacting structure of the yoke extends distally to engage tissue between the jaws to anchor the engaged tissue again lateral movement as the jaws contact the tissue.

Abstract: A device includes an anoscope including an elongated hollow member with a longitudinal slot configured to receive tissue in an interior of the hollow member. The device also includes a clip applicator. The clip applicator includes a body slidably received in the slot and jaws at a distal end of the body configured to hold a ligation clip. The clip applicator further includes a plunger slidably coupled to the body configured to actuate the jaws. When the clip applicator is inserted into the slot and the plunger is moved relative to the body, the jaws close and deform the ligation clip from an open position into a closed position around tissue received in the slot.

Abstract: A device includes an elongated hollow member having an open distal end for receiving tissue therein and at least one exterior groove for loading at least one ligation band thereon. The device also includes a band deployment sleeve slidable over the exterior of the hollow member and configured to move from a radially expanded position to a radially contracted position in which, when the band deployment sleeve slides longitudinally over the hollow member, the distal portion engages the at least one ligation band. A closing sleeve slidable over the exterior of the band deployment sleeve is configured to constrain the distal portion from the radially expanded position into the radially contracted position. Retracting the closing sleeve proximally over the distal portion of the band deployment sleeve releases the distal portion from the radially contracted position into the radially expanded position.

Abstract: A medical device includes opposing first and second end effectors coupled together to move from an open configuration to a closed configuration, a first link with a distal end pivotally connected to a proximal end of the first end effector, the first link including a first slot at a proximal end of the first link, a second link with a distal end pivotally connected to a proximal end of the second end effector, and a first actuator pin slidable within the first slot.