Abstract: The invention relates to a process for manufacturing a pre-impregnated fibrous material comprising a continuous fibre fibrous material and at least one thermoplastic polymer matrix, characterized in that said pre-impregnated fibrous material is made of a single unidirectional ribbon or a plurality of parallel ribbons unidirectional and in that said method comprises an impregnation step, in particular at the core, of said fibrous material being in the form of a roving or of several parallel rovings by said thermoplastic polymer being in powder form, said step of impregnation being carried out with said at least one thermoplastic polymer and said fibrous material the D90/D10 ratio of which by volume of the thermoplastic polymer particles ranges from 1.

Abstract: A method of manufacturing an impregnated fibrous material including a fibrous material made of continuous fibers and at least one thermoplastic polymer matrix, the method including pre-impregnating the fibrous material while it is in the form of a roving or several parallel rovings with the thermoplastic material and heating the thermoplastic matrix for melting, or maintaining in the molten state, the thermoplastic polymer after pre-impregnation, the at least one heating step being carried out by means of at least one heat-conducting spreading part (E) and at least one heating system, with the exception of a heated calendar, the roving or the rovings being in contact with part or all of the surface of the at least one spreading part (E) and partially or wholly passing over the surface of the at least one spreading part (E) at the level of the heating system.

Abstract: A method for selecting at least one satellite navigation service provider from a plurality of predetermined providers, the selection method being computer-implemented and comprising: a step for receiving a geographical position; a step of determining an indication relating to the authorization of use of at least one provider of the plurality of predetermined providers, the determining step being implemented by at least one artificial neural network (24) associated with said provider, an input variable of the artificial neural network (24) being the geographical position, an output variable of the artificial neural network (24) being said indication; a step for selecting at least one provider for satellite navigation of an aircraft.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: A cosmetic container may comprise a tubular sleeve that defines a cavity. The tubular sleeve may include a first end with a first opening and a second end with a second opening. The first opening may be defined by at least one upper sidewall which may include outer threads. The cosmetic container may include a cap assembly which may be configured to engage with the second opening of the second end, thereby sealing the second opening of the second end.

Abstract: Methods of manufacturing and fixtures for manufacturing containers, particularly for holding cosmetic products, using thin-walled tubes. One end of a container may be formed using an integral process, such as insert molding, while the other end of the container is formed using assembly steps, such as welding, to form a completed cosmetics container from a thin-walled tube.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A cosmetic container may include a base assembly including an open top and a closed bottom, and a cap configured to be removably coupled to the base assembly. The base assembly may include a helical slot on an inner surface. The cosmetic container may include a shell configured to fit within the base assembly, and a cup configured to fit within the shell. The cup may be configured to engage with the helical slot to move up and down within the cosmetic container. The cup may be configured for holding a cosmetic product stick. The base assembly, the shell, the cup and the cap may be formed from a same eco-friendly material.

Abstract: Methods of manufacturing and fixtures for manufacturing containers, particularly for holding cosmetic products, using thin-walled tubes. One end of a container may be formed using an integral process, such as insert molding, while the other end of the container is formed using assembly steps, such as welding, to form a completed cosmetics container from a thin-walled tube.

Abstract: A cosmetic container may include a bottle having a first open end and a second open end, defining a cavity therebetween. A sealing film may be adapted for placement at the second open end of the bottle, and a cap may be configured to engage with the second open end of the bottle, such that the cap fits over the sealing film thereby covering the sealing film and closing the second open end. The first open end may be adapted for dispensing a product held within the cavity of the bottle.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: An applicator device or dispenser includes a stone applicator tip and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The stone tip comprises a material that is capable of storing and retaining and/or transferring thermal energy during application of the product.