Patents by Inventor Denis Pierre

Denis Pierre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of cystic fibrosis transmembrane conductance regulator
    Patent number: 12168009
    Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
    Type: Grant
    Filed: July 14, 2022
    Date of Patent: December 17, 2024
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
  • MODULATOR OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
    Publication number: 20230357191
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Application
    Filed: August 4, 2022
    Publication date: November 9, 2023
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20230312616
    Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 5, 2023
    Inventors: Alexander Russell ABELA, Jeremy J. CLEMENS, Peter Diederik Jan GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Haripada KHATUYA, Jason McCARTNEY, Mark Thomas MILLER, Fabrice Jean Denis PIERRE, Joe Anh TRAN, Jinglan ZHOU
  • MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20230233560
    Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
    Type: Application
    Filed: July 14, 2022
    Publication date: July 27, 2023
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
  • Cosmetic container with a capped seal
    Patent number: 11641923
    Abstract: A cosmetic container may comprise a tubular sleeve that defines a cavity. The tubular sleeve may include a first end with a first opening and a second end with a second opening. The first opening may be defined by at least one upper sidewall which may include outer threads. The cosmetic container may include a cap assembly which may be configured to engage with the second opening of the second end, thereby sealing the second opening of the second end.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: May 9, 2023
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Denis Pierre Maurin, Thomas Sang Chun, Lewis On Hang Lee
  • Cosmetic containers and methods of manufacture
    Patent number: 11623411
    Abstract: Methods of manufacturing and fixtures for manufacturing containers, particularly for holding cosmetic products, using thin-walled tubes. One end of a container may be formed using an integral process, such as insert molding, while the other end of the container is formed using assembly steps, such as welding, to form a completed cosmetics container from a thin-walled tube.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: April 11, 2023
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Armando Villarreal, Thomas Sang Chun, Denis Pierre Maurin
  • MODULATOR OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS, METHODS OF TREATMENT, AND PROCESS FOR MAKING THE MODULATOR
    Publication number: 20220306606
    Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
    Type: Application
    Filed: October 20, 2021
    Publication date: September 29, 2022
    Inventors: Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli
  • Modulator of the cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Patent number: 11453655
    Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: September 27, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Timothy Alcacio, Corey Anderson, Paul Timothy Angell, Minson Baek, Jeremy J. Clemens, Thomas Cleveland, Lori Ann Ferris, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Anton V. Gulevich, Sara Sabina Hadida Ruah, Clara Kuang-Ju Hsia, Robert M. Hughes, Pramod Virupax Joshi, Ping Kang, Ali Keshavarz-Shokri, Haripada Khatuya, Paul John Krenitsky, Jason McCartney, Mark Thomas Miller, Prasuna Paraselli, Fabrice Jean Denis Pierre, Yi Shi, Muna Shrestha, David Andrew Siesel, Kathy Stavropoulos, Andreas P. Termin, Fredrick F. Van Goor, Johnny Uy, Timothy John Young, Jinglan Zhou
  • Modulators of cystic fibrosis transmembrane conductance regulator
    Patent number: 11426407
    Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
    Type: Grant
    Filed: March 31, 2020
    Date of Patent: August 30, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
  • Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Patent number: 11414439
    Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: August 16, 2022
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Alexander Russell Abela, Jeremy J. Clemens, Peter Diederik Jan Grootenhuis, Sara Sabina Hadida Ruah, Yoshihiro Ishihara, Haripada Khatuya, Jason McCartney, Mark Thomas Miller, Fabrice Jean Denis Pierre, Joe Anh Tran, Jinglan Zhou
  • Eco-friendly cosmetic container
    Patent number: 11297924
    Abstract: A cosmetic container may include a base assembly including an open top and a closed bottom, and a cap configured to be removably coupled to the base assembly. The base assembly may include a helical slot on an inner surface. The cosmetic container may include a shell configured to fit within the base assembly, and a cup configured to fit within the shell. The cup may be configured to engage with the helical slot to move up and down within the cosmetic container. The cup may be configured for holding a cosmetic product stick. The base assembly, the shell, the cup and the cap may be formed from a same eco-friendly material.
    Type: Grant
    Filed: March 11, 2020
    Date of Patent: April 12, 2022
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Denis Pierre Maurin, Thomas Chun, Qinnong Li
  • COSMETIC CONTAINERS AND METHODS OF MANUFACTURE
    Publication number: 20220055315
    Abstract: Methods of manufacturing and fixtures for manufacturing containers, particularly for holding cosmetic products, using thin-walled tubes. One end of a container may be formed using an integral process, such as insert molding, while the other end of the container is formed using assembly steps, such as welding, to form a completed cosmetics container from a thin-walled tube.
    Type: Application
    Filed: August 17, 2021
    Publication date: February 24, 2022
    Applicant: HCT GROUP HOLDINGS LIMITED
    Inventors: ARMANDO VILLARREAL, THOMAS SANG CHUN, DENIS PIERRE MAURIN
  • COSMETIC BOTTLE
    Publication number: 20210387777
    Abstract: A cosmetic container may include a bottle having a first open end and a second open end, defining a cavity therebetween. A sealing film may be adapted for placement at the second open end of the bottle, and a cap may be configured to engage with the second open end of the bottle, such that the cap fits over the sealing film thereby covering the sealing film and closing the second open end. The first open end may be adapted for dispensing a product held within the cavity of the bottle.
    Type: Application
    Filed: June 9, 2021
    Publication date: December 16, 2021
    Applicant: HCT GROUP HOLDINGS LIMITED
    Inventors: DENIS PIERRE MAURIN, THOMAS SANG CHUN
  • Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator
    Patent number: 11186566
    Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
    Type: Grant
    Filed: December 4, 2019
    Date of Patent: November 30, 2021
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Timothy Alcacio, Minson Baek, Peter Grootenhuis, Sara Sabina Hadida Ruah, Robert M. Hughes, Ali Keshavarz-Shokri, Rachel McAuley-Aoki, Jason McCartney, Mark Thomas Miller, Fredrick Van Goor, Beili Zhang, Corey Anderson, Thomas Cleveland, Bryan A. Frieman, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Vito Melillo, Fabrice Jean Denis Pierre, Andreas P. Termin, Johnny Uy, Jinglan Zhou, Alexander Russell Abela, Brett Bradley Busch, Prasuna Paraselli
  • Applicator device or dispenser with stone tip
    Patent number: 11064790
    Abstract: An applicator device or dispenser includes a stone applicator tip and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The stone tip comprises a material that is capable of storing and retaining and/or transferring thermal energy during application of the product.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: July 20, 2021
    Assignee: HCT Asia Limited
    Inventors: Timothy Thorpe, Armando Villarreal, Courtney Frances Haley, Denis Pierre Maurin
  • MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20210139514
    Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.
    Type: Application
    Filed: April 5, 2019
    Publication date: May 13, 2021
    Inventors: Alexander Russell ABELA, Jeremy J. CLEMENS, Peter Diederik Jan GROOTENHUIS, Sara Sabina HADIDA RUAH, Yoshihiro ISHIHARA, Haripada KHATUYA, Jason McCARTNEY, Mark Thomas MILLER, Fabrice Jean Denis PIERRE, Joe Anh TRAN, Jinglan ZHOU
  • MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
    Publication number: 20210052584
    Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
    Type: Application
    Filed: March 31, 2020
    Publication date: February 25, 2021
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Mark Thomas Miller, Corey Anderson, Vijayalaksmi Arumugam, Brian Richard Bear, Hayley Marie Binch, Jeremy J. Clemens, Thomas Cleveland, Erica Conroy, Timothy Richard Coon, Bryan A. Frieman, Peter Diederik Jan Grootenhuis, Raymond Stanley Gross, Sara Sabina Hadida-Ruah, Haripada Khatuya, Pramod Virupax Joshi, Paul John Krenitsky, Chun-Chieh Lin, Gulin Erdogan Marelius, Vito Melillo, Jason McCartney, Georgia McGaughey Nicholls, Fabrice Jean Denis Pierre, Alina Silina, Andreas P. Termin, Johnny Uy, Jinglan Zhou
  • Cosmetic tube with applicator
    Patent number: D949023
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: April 19, 2022
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Denis Pierre Maurin, Thomas Sang Chun, Lewis On Hang Lee
  • Flex dropper
    Patent number: D1016620
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: March 5, 2024
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Denis Pierre Maurin, Jae Bin
  • Flex dropper assembly
    Patent number: D1023776
    Type: Grant
    Filed: July 6, 2022
    Date of Patent: April 23, 2024
    Assignee: HCT GROUP HOLDINGS LIMITED
    Inventors: Denis Pierre Maurin, Armando Villarreal, Megan Rene Langdon