Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis by administering such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A cosmetic pad, which may be useful, for example, for cleansing or other cosmetic-related activity, includes an upper portion, a lower portion coupled to the upper portion, and a non-porous covering. The non-porous covering is disposed around at least the upper portion. The upper portion has a lower durometer than the lower portion.

Abstract: A brush with a replaceable head includes a handle, a collar releasably coupled to the handle, and a brush head releasably coupled to the collar. The brush head may include a plurality of bristles. The collar may include an engagement member that releasably engages the brush head when the collar is coupled to the handle.

Abstract: Containers for distributing products are disclosed. The containers comprise a bottle having at least one sidewall and defining a cavity therein. The bottle has at least one opening. The containers also include an actuator comprising at least one sidewall defining a cavity therein. The bottle also includes a tip including an orifice. The orifice is configured to dispense product therethrough. The actuator is positioned between the bottle and the tip.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed. Also disclosed are solid state forms of Compound 1 and salts and solvates thereof.

Abstract: Applicators for use in retrieving product (generally a liquid) from a reservoir, with an applicator for entry to the reservoir coupled to a cap. The cap is configured to be coupled to a bottle and to be selectively actuated by depressing a depressible actuator. The applicator includes a shaft and thermal tip formed from a material that stores and/or transmits thermal energy.

Abstract: A cosmetic container may include a base assembly including an open top and a closed bottom, and a cap configured to be removably coupled to the base assembly. The base assembly may include a helical slot on an inner surface. The cosmetic container may include a shell configured to fit within the base assembly, and a cup configured to fit within the shell. The cup may be configured to engage with the helical slot to move up and down within the cosmetic container. The cup may be configured for holding a cosmetic product stick. The base assembly, the shell, the cup and the cap may be formed from a same eco-friendly material.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.

Abstract: An applicator device or dispenser includes an applicator tip assembly and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The applicator tip assembly may be coupled to the housing and may comprise a thermal storage applicator portion having an application face for applying the product to a surface, the thermal storage applicator portion being made from a material that is capable of storing and retaining and/or transferring thermal energy during application of the product. The applicator tip assembly may further comprise a main body portion having a product delivery passageway extending through the main body portion for dispensing a product to the application face of the thermal storage applicator portion, the main body portion configured to at least partially enclose the thermal storage applicator portion at a periphery of the thermal storage applicator portion.

Abstract: A cosmetic container may comprise a tubular sleeve that defines a cavity. The tubular sleeve may include a first end with a first opening and a second end with a second opening. The first opening may be defined by at least one upper sidewall which may include outer threads. The cosmetic container may include a cap assembly which may be configured to engage with the second opening of the second end, thereby sealing the second opening of the second end.

Abstract: An applicator device or dispenser includes an applicator tip assembly and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The applicator tip assembly may be coupled to the housing and may comprise a thermal storage applicator portion having an application face for applying the product to a surface, the thermal storage applicator portion being made from a material that is capable of storing and retaining and/or transferring thermal energy during application of the product. The applicator tip assembly may further comprise a main body portion having a product delivery passageway extending through the main body portion for dispensing a product to the application face of the thermal storage applicator portion, the main body portion configured to at least partially enclose the thermal storage applicator portion at a periphery of the thermal storage applicator portion.

Abstract: A cosmetic container and applicator system for magnetic cosmetic products may include a housing defining a reservoir for containing a magnetic cosmetic product, and an applicator configured to extend into the reservoir. The applicator includes a magnet. A wiper may extend into the reservoir and have a bottom end with an opening through which the applicator extends. The wiper may be configured to remove excess product from the applicator as the applicator is withdrawn from the reservoir.

Abstract: Compounds of Formula I: pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: An applicator device or dispenser includes a stone applicator tip and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The stone tip comprises a material that is capable of storing and retaining and/or transferring thermal energy during application of the product.

Abstract: Cosmetics packaging and applicators including a gel based tip are described. Gel applicators may or may not be provided with a through-hole. In various embodiments, the gel may be a stand-alone gel or may be encapsulated in a membrane. The gel applicator provides a soft feel and may have cooling effect as well. In some embodiments, the applicator is mounted to a platform or a hollow insert and coupled to a container housing the cosmetics product.

Abstract: An applicator device or dispenser includes a stone applicator tip and a housing which may, in some examples, have a reservoir for containing a product, such as a cosmetics product or a medicinal product. The stone tip comprises a material that is capable of storing and retaining and/or transferring thermal energy during application of the product.