Patents by Inventor Dennis Keith

Dennis Keith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20150183830
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: September 29, 2014
    Publication date: July 2, 2015
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Methods for preparing purified lipopeptides
    Patent number: 8846610
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 30, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Methods for preparing purified lipopeptides
    Patent number: 8796224
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: August 5, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Methods for preparing purified lipopeptides
    Patent number: 8697638
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Grant
    Filed: August 26, 2008
    Date of Patent: April 15, 2014
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20140087425
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: July 31, 2013
    Publication date: March 27, 2014
    Applicant: Cubist Pharmaceuticals, Inc.
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20140024577
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: June 27, 2013
    Publication date: January 23, 2014
    Inventors: Dennis Keith, Ja-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Compositions and methods for increasing the oral absorption of antimicrobials
    Patent number: 8303989
    Abstract: The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a biopolymer that is preferably swellable and/or mucoadhesive, a antimicrobial agent, and a cationic binding agent contained within the biopolymer such that the binding agent is ionically bound or complexed to at least one member selected from the group consisting of the biopolymer and the antimicrobial agent.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: November 6, 2012
    Inventors: Seung-Ho Choi, Jeoung-Soo Lee, Dennis Keith
  • METHODS FOR PREPARING PURIFIED LIPOPEPTIDES
    Publication number: 20100041589
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: August 26, 2008
    Publication date: February 18, 2010
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • COMPOSITIONS AND METHODS FOR INCREASING THE ORAL ABSORPTION OF ANTIMICROBIALS
    Publication number: 20090264340
    Abstract: The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a biopolymer that is preferably swellable and/or mucoadhesive, a antimicrobial agent, and a cationic binding agent contained within the biopolymer such that the binding agent is ionically bound or complexed to at least one member selected from the group consisting of the biopolymer and the antimicrobial agent.
    Type: Application
    Filed: April 16, 2009
    Publication date: October 22, 2009
    Inventors: SEUNG-HO CHOI, JEOUNG-SOO LEE, DENNIS KEITH
  • METHODS FOR PREPARING PURIFIED LIPOTIDES
    Publication number: 20090197799
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: August 26, 2008
    Publication date: August 6, 2009
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Compositions and methods for increasing the oral absorption of antimicrobials
    Patent number: 7527807
    Abstract: The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a biopolymer that is preferably swellable and/or mucoadhesive, a antimicrobial agent, and a cationic binding agent contained within the biopolymer such that the binding agent is tonically bound or complexed to at least one member selected from the group consisting of the biopolymer and the antimicrobial agent.
    Type: Grant
    Filed: June 22, 2001
    Date of Patent: May 5, 2009
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Seung-Ho Choi, Jeoung-Soo Lee, Dennis Keith
  • Novel Lipopeptides as Antibacterial Agents
    Publication number: 20090011977
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: June 27, 2008
    Publication date: January 8, 2009
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Novel Lipopeptides as Antibacterial Agents
    Publication number: 20080287347
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: June 27, 2008
    Publication date: November 20, 2008
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 7408025
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: August 5, 2008
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 7335725
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: February 26, 2008
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Methods for preparing purified lipopeptides
    Publication number: 20060014674
    Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.
    Type: Application
    Filed: April 18, 2005
    Publication date: January 19, 2006
    Inventors: Dennis Keith, Jan-Ji Lai, Chandrika Govardhan, Nazer Khalaf
  • Novel lipopeptides as antibacterial agents
    Publication number: 20050203006
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: May 4, 2005
    Publication date: September 15, 2005
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 6911525
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: June 28, 2005
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Lipopeptides as antibacterial agents
    Patent number: 6794490
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: September 21, 2004
    Assignee: Cubist Pharmaceuticals, Inc.
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xian Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang
  • Novel lipopeptides as antibacterial agents
    Publication number: 20040067878
    Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
    Type: Application
    Filed: December 15, 2000
    Publication date: April 8, 2004
    Inventors: Jason Hill, Ian Parr, Michael Morytko, Jim Siedlecki, Xiang Yang Yu, Jared Silverman, Dennis Keith, John Finn, Dale Christensen, Tsvetelina Lazarova, Alan D. Watson, Yan Zhang