Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula: 1

Abstract: Rope made of cellulose fibers, the polymeric chemical structure of which fibers has not been modified (referred to as “raw” cellulose fibers), are subjected to intense electron beam irradiation insufficient to degrade their chemical structure but sufficient to modify their physical structure so as to allow them to be comminuted into fragments having a length no more than 6.35 mm (0.25″), preferably less than 3.175 mm (0.125″), and preferably 50% by weight of the fibers have a length less than 70 &mgr;m. Such fragments of fibers are found to be particularly susceptible to being micronized in a micronizer into elongated granular fragments smaller than about 20 &mgr;m at an economical production rate in excess of 22.7 Kg/hr (50 lb/hr) which was not possible when the micronizer was fed with naturally occurring fibers.

Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

Abstract: The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

Abstract: Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology having the following formulas:

Abstract: Compounds used for treating dependence on or withdrawal from a drug of abuse, for an eating disorder or for a CNS disease or pathology having the following formulas: 1

Abstract: A lap edge sealant composition is provided for adhering together overlapping sheets of roofing material which includes a rubbery polymer such as EPDM, a thermoplastic rubber, a tackifier, and a solvent, where the solvent is selected from aliphatic hydrocarbons, para-chlorobenzotrifluoride, or blends thereof. The lap edge sealant has a high solids content of about 65 to 90%, a volatile organic compound (VOC) content of less than about 250 g/l, and exhibits no more than about 35% shrinkage upon curing.

Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; L is —C(O)N(Q)CH2—, or —CR10R11OCR12R13—; Q is hydrido, —(CH2)mCO2H and —(CH2)mCO2CH3, m is 1, 2, 3, and 4; R1, R2, R9, R10, R11, R12 and R13 are hydrido or lower alkyl; wherein Het is a heterocyclic moiety, the inhibitors are suitable for use as antimicrobial agents.

Abstract: Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.

Abstract: The present invention relates to methods of providing crystalline and crystal-like forms of daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying daptomycin.

Abstract: The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

Abstract: The present invention provides compositions and methods for increasing absorption of antibacterial agents, particularly third generation cephalosporin antibacterial agents, in oral dosage solid and/or suspension forms. Specifically, the composition is comprised of a biopolymer that is preferably swellable and/or mucoadhesive, a antimicrobial agent, and a cationic binding agent contained within the biopolymer such that the binding agent is tonically bound or complexed to at least one member selected from the group consisting of the biopolymer and the antimicrobial agent.

Abstract: Transfer ribonucleic acid (tRNA) synthetase inhibitors, salts, and pharmaceutically acceptable compositions thereof of the general formula: 1

Abstract: A capacitance measuring circuit having a sensor electrode and a reference electrode that are spaced apart so that a material can be positioned between the two electrodes. A first polarity and a second polarity voltage source are used to charge the sensor electrode and a switch controller controls the charging and discharging of a capacitor by the sensor electrode. The charge on the capacitor after being charged and at least partially discharged by the sensor electrode represents the capacitance between the sensor electrode and the reference electrode. The charge on the capacitor is used to measure the position of the material relative to the sensor and reference electrode. The measuring circuit also has a system parasitic controller to measure and adjust for system parasitic capacitance in the measuring circuit.

Abstract: A rubber composition is provided comprising a diene-based elastomer, a vulcanizing agent, a vulcanizing accelerator and a reinforcement comprising a conical carbon. The conical carbon comprises cones, flat plates, nanotubes and fullerenes. Also provided is a tire having at least one component fabricated from the rubber composition.