Patents by Inventor Derek Jantz

Derek Jantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
    Patent number: 8445251
    Abstract: Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: May 21, 2013
    Assignee: Precision BioSciences, Inc.
    Inventors: James J. Smith, Derek Jantz
  • Method for producing genetically-modified cells with rationally-designed meganucleases with altered sequence specificity
    Patent number: 8377674
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: February 19, 2013
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Rationally-designed meganuclease variants of lig-34 and I-crei for maize genome engineering
    Patent number: 8338157
    Abstract: The invention relates to the field of molecular biology and recombinant nucleic acid technology. In particular, the invention relates to a rationally-designed, non-naturally-occurring meganuclease with altered DNA recognition sequence specificity which recognizes and cleaves a unique DNA site in the maize genome. Disclosed herein are meganucleases which are variants of the I-CreI and LIG-34meganucleases. The invention also relates to methods of producing engineered maize plants using such meganucleases.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: December 25, 2012
    Assignee: Precision Biosciences, Inc.
    Inventors: Derek Jantz, James Jefferson Smith
  • Rationally-designed meganucleases with altered sequence specificity and heterodimer formation
    Patent number: 8304222
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: November 6, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • METHODS OF PRODUCING GENETICALLY-MODIFIED EUKARYOTIC CELLS WITH RATIONALLY-DESIGNED MEGANUCLEASES
    Publication number: 20120266266
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: June 25, 2012
    Publication date: October 18, 2012
    Applicant: DUKE UNIVERSITY
    Inventors: James J. SMITH, Derek JANTZ, Homme W. HELLINGA
  • Rationally-Designed Meganucleases With Altered Sequence Specificity and DNA-Binding Affinity
    Publication number: 20120264189
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: April 26, 2012
    Publication date: October 18, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8163514
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: April 24, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8148098
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: April 3, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8143015
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: March 27, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8143016
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 27, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120070877
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: December 1, 2011
    Publication date: March 22, 2012
    Applicant: Duke University
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8133697
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 13, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8129134
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: March 6, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Method of cleaving DNA with rationally-designed meganucleases
    Patent number: 8124369
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 27, 2011
    Date of Patent: February 28, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Methods of cleaving DNA with rationally-designed meganucleases
    Patent number: 8119361
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 21, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
    Patent number: 8119381
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: February 21, 2012
    Assignee: Duke University
    Inventors: James Jefferson Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120040406
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: February 16, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120040405
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 26, 2011
    Publication date: February 16, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120030783
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 1, 2011
    Publication date: February 2, 2012
    Applicant: Duke University
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120028314
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: February 2, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga