Patents by Inventor Derek Jantz

Derek Jantz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120028315
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: February 2, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120021465
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: January 26, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120021520
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: January 26, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120021521
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 27, 2011
    Publication date: January 26, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120015406
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
    Publication number: 20120015421
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: September 26, 2011
    Publication date: January 19, 2012
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
    Patent number: 8021867
    Abstract: Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: September 20, 2011
    Assignee: Duke University
    Inventors: James J. Smith, Derek Jantz, Homme W. Hellinga
  • RECOGNITION SEQUENCES FOR I-CREI-DERIVED MEGANUCLEASES AND USES THEREOF
    Publication number: 20110202479
    Abstract: Methods of cleaving double-stranded DNA that can be recognized and cleaved by a rationally-designed, I-CreI-derived meganuclease are provided. Also provided are recombinant nucleic acids, cells, and organisms containing such recombinant nucleic acids, as well as cells and organisms produced using such meganucleases. Also provided are methods of conducting a custom-designed, I-CreI-derived meganuclease business.
    Type: Application
    Filed: January 14, 2011
    Publication date: August 18, 2011
    Inventors: Derek JANTZ, James J. SMITH
  • FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS
    Publication number: 20110123509
    Abstract: Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional effectors can comprise (i) a meganuclease DNA-binding domain lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector domain.
    Type: Application
    Filed: October 28, 2010
    Publication date: May 26, 2011
    Inventors: Derek JANTZ, Michael G. NICHOLSON, James J. SMITH
  • RATIONALLY-DESIGNED MEGANUCLEASES FOR MAIZE GENOME ENGINEERING
    Publication number: 20110113509
    Abstract: The invention relates to the field of molecular biology and recombinant nucleic acid technology. In particular, the invention relates to a rationally-designed, non-naturally-occurring meganuclease with altered DNA recognition sequence specificity which recognizes and cleaves a unique DNA site in the maize genome. The invention also relates to methods of producing engineered maize plants using such meganucleases.
    Type: Application
    Filed: September 10, 2010
    Publication date: May 12, 2011
    Applicant: PRECISION BIOSCIENCES, INC.
    Inventors: Derek JANTZ, James Jefferson SMITH
  • RATIONALLY-DESIGNED MEGANUCLEASES WITH RECOGNITION SEQUENCES FOUND IN DNASE HYPERSENSITIVE REGIONS OF THE HUMAN GENOME
    Publication number: 20110033935
    Abstract: Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: June 7, 2010
    Publication date: February 10, 2011
    Applicant: Precision Biosciences, Inc.
    Inventors: Derek Jantz, Michael G. Nicholson, James J. Smith
  • RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES
    Publication number: 20100311817
    Abstract: Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
    Type: Application
    Filed: April 30, 2010
    Publication date: December 9, 2010
    Inventors: James J. Smith, Derek Jantz
  • TEMPERATURE-DEPENDENT MEGANUCLEASE ACTIVITY
    Publication number: 20100071083
    Abstract: The invention relates to methods for the production of genetically modified plants using engineered meganucleases and elevated temperature and to genetically modified plants produced by such methods.
    Type: Application
    Filed: March 12, 2009
    Publication date: March 18, 2010
    Inventors: James J. Smith, Derek Jantz
  • Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
    Publication number: 20070117128
    Abstract: Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.
    Type: Application
    Filed: October 18, 2006
    Publication date: May 24, 2007
    Inventors: James Smith, Derek Jantz, Homme Hellinga