Abstract: An installation system and method configured to install a lower completion section is provided. The installation system may comprise an installation drill pipe configured to releasably couple with a lower completion section. The installation system may comprise an electrical wet connect. The electrical wet connect may be coupled with a connector configured to establish a communication pathway between the electrical wet connect and components of the lower completion section. The lower completion section may be run in hole. Communications between a surface location and the lower completion components may be established via the electrical wet connect. The lower completion components may be tested prior to setting a lower completion section packer.

Abstract: In one aspect, the present invention features a tablet including: (i) a first drug layer including naproxen; (ii) a second drug layer including a decongestant (e.g., pseudoephedrine) wherein said second drug layer is a sustained release layer adapted to deliver a therapeutically effective amount of pseudoephedrine for a period of at least twelve hours; and (iii) a barrier layer that does not include naproxen, wherein the barrier layer is in contact with the first drug layer; and (iv) a third drug layer including cetirizine, wherein the third drug layer is in contact with the barrier layer and is not in contact with the first drug layer.

Abstract: In one aspect, the present invention features a tablet including a first drug layer, a second drug layer, and a third drug layer, wherein (i) the first drug layer includes naproxen; (ii) a second drug layer including pseudoephedrine; and (iii) the third drug layer includes cetirizine; wherein the first drug layer is in contact with the second drug layer, the third drug layer is in contact with the second drug layer, and the first drug layer is not in contact with the third drug layer, and wherein the second drug layer is a sustained release layer adapted to deliver a therapeutically effective amount of pseudoephedrine for a period of at least twelve hours.

Abstract: The present invention is directed to methods of treating eye disease. In one embodiment, the method can comprise administering a taxane-cobalamin bioconjugate or another taxane compound to a subject to treat the eye disease. In one embodiment, the bioconjugate can be dissolved in an aqueous solution prior to administration.

Abstract: The present invention generally relates to methods useful for a therapy using a class of urea or amide compounds and related compositions, wherein the compound is a soluble epoxide hydrolase inhibitor, for treating and ameliorating the symptoms of diseases related to endothelial dysfunction.

Abstract: In one general embodiment, a method includes, from within a single application running under control of an operating system, receiving a request to launch a first task, outputting a first tabbed page having a first tab and information relating to the first task, receiving a request to launch a second task, outputting a second tabbed page having a second tab and information relating to the second task, launching a sub goal modal to the first task, suspending access to the first task pending resolution of the sub goal, displaying information about the sub goal upon receiving user selection of the first tab during suspension of the first task, and allowing access to the second task during suspension of the first task.

Abstract: The present invention relates to a novel process for isolation and recovery of compounds such as biosynthetically produced simvastatin in either lactone form or in the form of its acid salt in high yield and purity, from microbial fermentation broth and isolating the said statin from harvested microbial broth.

Abstract: The present invention is directed to methods and compositions including a taxane covalently bonded to the cobalt atom of a cobalamin. The composition can be delivered by any effective route, but is particularly useful as an oral anti-cancer or antiangiogenic compound. The anti-cancer/anti-angiogenic compound can be used in various chemotherapies including anti-angiogenic chemotherapies, alone or in combination with other anti-cancer/anti-angiogenic compounds.

Abstract: Disclosed are alpha keto amide and alpha hydroxy amide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such compounds and compositions. The compounds, compositions, and methods are useful for treating a variety of sEH mediated diseases, including hypertensive, cardiovascular, inflammatory, pulmonary, and diabetic-related diseases.

Abstract: The present invention provides certain [3.1.0]bicyclic oxazolidinone derivatives of Formula I I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Abstract: A completion system for use in the well includes a liner for lining the well, where the liner has a first inductive coupler portion. An electric cable extends outside an inner passage of the liner. The completion system further includes a second inductive coupler portion and an electrical device inside the liner and electrically connected to the second inductive coupler portion. The first and second inductive coupler portions enable power to be provided from the electric cable outside the inner passage of the liner to the electrical device inside the liner.

Abstract: A system for use in a well includes a string for placement in the well, where the string including an electric pump and a first inductive coupler portion. A completion section is deployed in a zone of the well to be developed, where the completion section includes a second inductive coupler portion for inductive coupling to the first inductive coupler portion. An electrical device is electrically connected to the second inductive coupler portion.

Abstract: A gravel pack service tool is lowered into a well. At least one sensor proximate a well region to be gravel packed measures at least one characteristic of the well, where the measuring is performed during a gravel pack operation by the gravel pack service tool. The gravel pack service tool is removed from the well after the gravel pack operation.

Abstract: A completion system for use in a well includes a first completion section and a second section. The first completion section has a sand control assembly to prevent passage of particulates, a first inductive coupler portion, and a sensor positioned proximate to the sand control assembly that is electrically coupled to the first inductive coupler portion. The second section is deployable after installation of the first completion section. It includes a second inductive coupler portion to communicate with the first inductive coupler portion, to enable communication between the first completion section's sensor and another component coupled to the second section.

Abstract: Novel compositions and methods are provided for modifying adipocyte physiology in an animal subject such as a human. The methods include administering to the animal subject a novel pharmaceutical compositions derived from Cinnamomi cassia extracts and hypoglycemic therapeutics. Also provided are methods of increasing insulin sensitivity in an animal, which comprise administering to the animal an amount of a combination of cinnamon and metformin or glipizide sufficient to increase insulin sensitivity. Also provided are methods of treating disorders related to insulin resistance.

Abstract: Zonal isolation tools and methods of using same are described. The zonal isolation tools include a wellbore sealing member expandable by fluid pressure to contact a wellbore over an initial contact area, an inflation valve open during expansion of the sealing member to the initial contact area and closed upon the fluid pressure reaching a predetermined setting, a vent between the sealing member and a wellbore annulus adapted to open after the inflation valve is closed, and a compressive load imparted to the sealing member via a linear piston to achieve a sealing point at the leading edge of the sealing member. This abstract allows a searcher or other reader to quickly ascertain the subject matter of the disclosure. It will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention is related to therapeutic uses of dehydroepiandrosterone (DHEA) congeners. More specifically, the present invention relates to the co-administration of a dehydroepiandrosterone (DHEA) congener in combination with at least one other pharmaceutically active agent to treat or prevent cancer.

Abstract: Disclosed are compounds of formula I that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.

Abstract: A technique is provided for completing a subterranean wellbore. A wellbore completion combines a distributed sensing system, such as a distributed temperature sensing system, with at least one flow control valve and a pumping system. The flow control valve is controllable without the need for intervention or with low-cost intervention.

Abstract: The present invention provides for a valve in a tubing string that allows the tubing string to fill with well fluids as the string is assembled and lowered into a well bore, but can be used to check pressure integrity of the tubing string during various stages of the assembly.