Abstract: A system that is usable with a subterranean well includes a winding, a member and a circuit. The winding is located downhole in the well, and the member moves relative to the winding in response to vibration occurring in the well to cause a signal to be generated on the winding. The circuit is coupled to the winding to respond to the signal to provide power to operate a component located downhole in the well.

Abstract: In general, a system and valve is provided to prevent the cross flow between formations during the shut-in period of a well intersecting at least two formations, with flow from at least one of the formations being controlled by a multi-position valve. In one embodiment, the system comprises a cross-flow prevention valve that automatically closes and then opens during each cycle of the multi-position valve. In another embodiment, the cross-flow prevention valve is activated by the same control line used to activate the multi-position valve.

Abstract: The present invention is related to therapeutic uses of dehydroepiandrosterone (DHEA) congeners. More specifically, the present invention relates to the co-administration of a dehydroepiandrosterone (DHEA) congener in combination with at least one other pharmaceutically active agent to reduce inflammation.

Abstract: The present invention provides for a completion assembly having a line slack compensator to provide or remove slack in a control line.

Abstract: A control line can be positioned in a downhole completion. For example, the control line can be deployed in a protected position along a stinger to reduce the potential for damaging the control line during installation, removal or operation.

Abstract: N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, salts or prodrugs thereof have interesting properties, e.g., in the treatment or prevention of disorders amenable to treatment by PDF inhibitors, such as treatment of bacterial infections.

Abstract: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

Abstract: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

Abstract: The multiple interventionless actuated downhole valve includes a valve movable between an open and a closed position to control communication between an annular region surrounding the valve and an internal bore and more specifically controlling communication between above and below the valve, and at least two remotely operated interventionless actuators in operational connection with the valve, wherein each of the interventionless actuators may be operated independently by absolute tubing pressure, absolute annulus pressure, differential pressure from the tubing to the annulus, differential pressure between the annulus and the tubing, tubing or annulus multiple pressure cycles, pressure pulses, acoustic telemetry, electromagnetic telemetry or other types of wireless telemetry to change the position of the valve and allowing the valve to be continually operated by mechanical apparatus.

Abstract: The invention is a system and method used to seal between an open wellbore and a tubing by bringing the wellbore wall inwardly so as to enable sections of earth from the wellbore wall to create the required seal against the tubing. The earth sections that make up the seal can be created by collapsing the relevant parts of the wellbore wall inwardly or by causing the relevant parts of the wellbore wall to swell inwardly.

Abstract: The invention is a sealing system, such as a packer, that is used in a wellbore to seal against an exterior surface, such as a casing or open wellbore. The sealing system includes a swellable material that swells from an unexpanded state to an expanded state thereby creating a seal when the swellable material comes into contact with a triggering fluid.

Abstract: Disclosed are compounds that inhibit proteasomic activity in cells. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly cell proliferative conditions, such as cancer and inflammatory conditions.

Abstract: Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC.

Abstract: The present invention provides certain [3.1.0] bicyclic oxazolidinone derivatives of formula I or pharmaceutically acceptable salts or prodrugs thereof that are antibacterial agents, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Abstract: The present invention provides for an annular barrier tool to block or restrict the flow of well fluids in the annular region of a well.

Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein A, X, Y, Z, R2, R3, R4, R5, and R6 are as defined herein. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.

Abstract: In cramp bark preparations or tinctures currently available, there are no such preparations that have been standardized to a marker compound. In this type of standardization, one compound serves as a marker to indicate the presence of an identified active ingredient as well as the presence of other constituents that give the herb its therapeutic properties. The invention identifies a compound and a process by which to standardize preparations of cramp bark (Verbena Officinalis) and related species such as black haw, of the Genus Viburnum of the Caprifoliaceae family (herein cramp bark). Verbenalin is an iridoid glycoside, and an alkaloid as well. The extraction process enriches or fortifies the yield of aglycon alkaloids and alkaloid glycosides in the botanical material of the Genus Viburnum family, including cramp bark. Alkaloid glycosides include, without limitation, verbenalin, hastatoside, and verbacoside.

Abstract: The present invention provides antibacterial agents of formula I, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention provides a composition of transdermally administered alkaloids from aconitum plant for ameliorating pain and inflammation. In one aspect, an aconitum alkaloid is delivered in a sufficient amount to achieve and maintain a blood plasma aconitum alkaloid level of about 0.5 ng/mL to about 400 ng/mL. Aconitum alkaloids may be delivered by themselves, or in combination with other elements, such as additional analgesics, other drugs, or positive health promoting substances. Various formulations for the transdermal delivery of aconitum alkaloids are disclosed, and may include selected penetration enhancers.

Abstract: Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.