Abstract: Aspects of the disclosure are directed to a method for use on a blockchain network that includes an accounting node subnetwork having accounting nodes configured to record a data block onto a blockchain and a service node having service nodes configured to verify data blocks recorded by the accounting nodes onto the blockchain. The method can include generating a signature based on transaction information to be included in a data block to be added onto the blockchain by using a key specific to the accounting node. The method can further include adding the transaction information and the generated signature to the data block and adding the data block onto the blockchain, and transmitting the signature to the service nodes in the service node subnetwork, so that the service nodes perform signature verification on the signature based on the key specific to the accounting node.

Abstract: Disclosed is a compound of formula I or a pharmaceutically acceptable salt, active metabolite, tautomer, stereoisomer, or prodrug thereof as BTK (Bruton's Tyrosine Kinase) inhibitors, which is useful for the treatment of autoimmune disease, inflammatory disease, cancer and potentially allergies.

Abstract: Disclosed herein is a method for producing a sialylated N-glycosylated recombinant protein in periplasm of a recombinant Escherichia coli. The sialylated N-glycosylated recombinant protein is produced in the periplasm of a recombinant Escherichia coli strain W3110?nanKETA::Kan, and a sialylated oligosaccharide chain is Neu5Ac-?-2,6-Gal-?-1,4-GlcNAc-?-1,3-Gal-?-1,3-GlcNAc.

Abstract: One or more embodiments herein can enable identification of an obstacle free area about an object. An exemplary system can comprise a memory that stores computer executable components, and a processor that executes the computer executable components stored in the memory, wherein the computer executable components can comprise an obtaining component that obtains raw data defining a physical state of an environment around an object from a vantage of the object, and a generation component that, based on the raw data, generates a dimension of a portion or more of a virtual polygon representing a boundary about the object, wherein the boundary bounds free space about the object. A sensing sub-system can comprise both an ultrasonic sensor and a camera that can separately sense the environment about the object from the vantage of the object to thereby generate separate polygon measurement sets.

Abstract: The present application discloses a data query method, comprising: receiving a data query request, the data query request being used for querying data from a columnar storage system which applies object storage technology, the columnar storage system comprising an index file and a data file which are stored individually. After receiving the data query request, the index file is obtained based on the data query request, i.e., the whole index file may be obtained when receiving the data query request. Afterwards, a storage range in the data file of target data which matches the data query request determined based on the index file, and further, a network input and output (IO) is called to read the target data stored in the storage range. As such, it can reduce the number of calls to the network IO and further improves the efficiency of querying data from the columnar storage system.

Abstract: A graphene oxide (GO)-silver nanoparticles (AgNPs)-Eu3+ fluorescent probe, a paper-based sensor, and a preparation method and use thereof are provided. The paper-based sensor is developed based on a GO-AgNPs-Eu3+ fluorescent probe-loaded polyvinylidene fluoride (PVDF) microporous membrane, which is further combined with a smartphone. The GO-AgNPs-Eu3+ fluorescent probe shows high selectivity for 2,6-dipicolinic acid (DPA), strong anti-interference ability, and low limit of detection (LOD) for the DPA and spores. The paper-based sensor realizes quantitative detection of the DPA and the spores through red, green, and blue (RGB) changes of the smartphone, and detection results are verified by an actual amount of the spores in milk and water. The rapid detection of foodborne spores is achieved through a dual-function platform based on fluorescence of the GO-AgNPs-Eu3+ fluorescent probe and the paper-based sensor.

Abstract: Embodiments of this application provide a method, an apparatus, and a device for screen display, and a storage medium. Spectral information of light of a plurality of sub-colors in an original color light color gamut of a screen display picture is obtained separately. A melanopic lux per photopic lux ratio of the light of the sub-colors is calculated based on the spectral information of the light of the sub-colors. Sub-color light having a melanopic lux per photopic lux ratio that exceeds a preset melanopic lux per photopic lux ratio standard is eliminated from the original color light, so that the screen displays updated color light, where the preset melanopic lux per photopic lux ratio standard is a standard set based on a goal of reducing melatonin inhibition. The sub-color light is eliminated in a targeted manner based on the preset melanopic lux per photopic lux ratio standard.

Abstract: The present invention provides a modified bismaleimide prepolymer, a resin composition and application thereof. The modified bismaleimide prepolymer is obtained by a reaction of a bismaleimide compound with an amino organosilicone resin A and an amino organosilicone resin B, where the amino equivalent (EaA) of the amino organosilicone resin A is different from the amino equivalent (EaB) of the amino organosilicone resin B, and the ratio of the total mass of the amino organosilicone resin A and the amino organosilicone resin B to the mass of the bismaleimide compound is (5-80):100. According to the present invention, the reactivity of the bismaleimide compound is improved, and the rheological property of the modified bismaleimide prepolymer applied in the field of substrate materials such as packaging substrates during lamination at high temperature is controlled.

Abstract: The present application provide a compound represented by formula (I), a chiral enantiomer thereof or a pharmaceutically acceptable salt thereof, and a preparation method therefor, an intermediate for preparing the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and a preparation method therefor, a pharmaceutical composition comprising the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof, and pharmaceutical use of the compound represented by formula (I), the chiral enantiomer thereof or the pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the same. The compounds of the present application exhibit good JAK2 kinase inhibitory activity and high selectivity for JAK2 kinase.

Abstract: Thermal Energy Storage A thermal energy storage module comprising a composite phase change material, wherein the composite phase change material comprises: a phase change material having a composition which absorbs or releases heat isothermally, or substantially isothermally, by transitioning, in a respective transition direction, between a first phase state and a second phase state at a predetermined transition temperature, wherein the composite phase change material comprises at least 40 wt % of the phase change material, based on the total weight of the composite phase change material, the phase change material being in the form of a continuous phase, a discrete phase, or a mixture of continuous and discrete phases distributed within the composite phase change material; a structural material for structurally shape-stabilising the phase change material, the structural material comprising particles which are solid in a predetermined working temperature range including the predetermined transition temperature

Abstract: The invention provides an oral solid formulation comprising (a) one or more controlled release components comprising a core comprising levodopa, esters or salts thereof and wherein the one or more controlled release components; and (b) one or more immediate release components comprising levodopa, esters or salts thereof. The oral solid formulation also contains a decarboxylase inhibitor and about 80% to 100% of the decarboxylase inhibitor present in the oral solid formulation is present in the one or more immediate release components.

Abstract: The slow kinetics and low efficiency of reprogramming methods to generate human induced pluripotent stem cells (iPSCs) impose major limitations on their utility in biomedical applications. Here we describe a chemical approach that dramatically improves (>200 fold) the efficiency of iPSC generation from human fibroblasts, within seven days of treatment. This will provide a basis for developing safer, more efficient, non-viral methods for reprogramming human somatic cells.

Abstract: Described herein are PKMYT1 (Myt1) inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of a disease or disorder associated with PKMYT1.

Abstract: Provided is an anti-B7-H4 antibody containing a VH, wherein the VH contains the following CDRs or a mutation thereof: CDR1 as shown in the amino acid sequence of SEQ ID NO: 4 or 5, CDR2 as shown in the amino acid sequence of SEQ ID NO: 15, and CDR3 as shown in the amino acid sequence of SEQ ID NO: 24 or 25, and wherein the mutation is an insertion, deletion or substitution of 3, 2 or 1 amino acid(s) in the amino acid sequences of the CDRs. The antibody has the activity of binding to human B7-H4 and cynomolgus monkey B7-H4. The antibody still retains the activity of binding to human B7-H4 and cynomolgus monkey B7-H4 when prepared into a B7-H4×CD3 bispecific antibody, and has a strong killing effect on tumor cells. The antibody induces a very low expression of nonspecific cytokines such as IL-6 and IFN-?, and exhibits a strong in vivo anti-tumor activity.

Abstract: A high-load organic wastewater dark fermentation biohydrogen production device and a hydrogen production method are provided. An exhaust port of the production device is communicated with a gas collection region through a gas pipe; a return inlet is arranged at a bottom; a baffle plate is arranged in a two-phase separation device; the baffle plate has a helical shape that makes influent water form a helical centripetal water flow path; one end of an inert gas communicating pipe is connected with an air hole at a bottom of the gas collection region; the other end of the inert gas communicating pipe is communicated with an air intake disc; the inert gas communicating pipe is provided with a connecting hole and an air pump; and the gas collection region is connected with a gas buffer tank and a hydrogen storage tank in sequence. A two-phase separation unit is also provided.

Abstract: The present application relates to a passive radiator mechanism and a speaker box. The passive radiator mechanism includes a passive radiator assembly and a protective cover, the passive radiator assembly includes a passive vibration plate and at least two protruding portions arranged on a first surface of the passive vibration plate. The protective cover is disposed outside the passive vibration plate and is opposite to the first surface, and the protective cover is provided with a plurality of passages penetrating the protective cover. The passive vibration plate is configured to vibrate with the sound of the speaker box and can drive the protruding portions to move between a first position and a second position, and the protective cover is located between the first position and the second position. The passive radiator mechanism can protect the passive vibration plate during vibration and prevent sound blockage.

Abstract: Disclosed are a maize on-demand fertilization control system and a soil nitrogen soft measurement method. Sensors transmit real-time data to a control unit, which calculates soil nitrogen content using an optimized BP neural network model. Based on maize's nitrogen demand, the system adjusts fertilization amounts using solenoid valves, achieving precise, cost-effective fertilization.

Abstract: The present application provides a semiconductor device, a method for manufacturing a semiconductor device, and an electronic device. Two semiconductor layers having different carrier mobilities are provided, the semiconductor layer having a lower carrier mobility covers the semiconductor layer having a higher carrier mobility, and the semiconductor layer having a higher carrier mobility is located within the coverage area of a first electrode.

Abstract: An enclosure for an electronic device includes a metal substrate, a porous anodic oxide layer overlaying the metal substrate, and a hydrothermal sealant disposed on the anodic oxide layer, the hydrothermal sealant including a molten salt.

Abstract: The disclosure relates to a system and method for image reconstruction. The method may include the steps of: obtaining raw data corresponding to radiation rays within a volume, determining a radiation ray passing a plurality of voxels, grouping the voxels into a plurality of subsets such that at least some subset of voxels are sequentially loaded into a memory, and performing a calculation relating to the sequentially loaded voxels. The radiation ray may be determined based on the raw data. The calculation may be performed by a plurality of processing threads in a parallel hardware architecture. A processing thread may correspond to a subset of voxels.