Abstract: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.

Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.

Abstract: The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD3 or halogen; R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl; R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4) hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.

Abstract: The system relates to a system and apparatus for a scalable engineering system deployed in production that mines topical interests from multiple social networks and assigns over tens of thousands of topics to hundreds of millions of users on a daily basis. The system extracts and analyzes features for topic inference that extend beyond authored text. The system uses a diverse set of features and cross network information can lead to a better understanding of a user's interests. This system focuses on assigning topics for a user that other users can socially recognize and acknowledge.

Abstract: Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Abstract: Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.

Abstract: User profile information for a user of a social networking system is inferred based on information about user profile of the user's connections in the social networking system. The inferred user profile attributes may include age, gender, education, affiliations, location, and the like. To infer a value of a user profile attribute, the system may determine an aggregate value based on the attributes of the user's connections. A confidence score may also be associated with the inferred attribute value. The set of connections analyzed to infer a user profile attribute may depend on the attribute, the types of connections, and the interactions between the user and the connections. The inferred attribute values may be used to update the user's profile and to determine information relevant to the user to be presented to the user (e.g., targeting advertisements to the user based on the user's inferred attributes).

Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.

Abstract: A social networking system extends the reach of an ad by allowing an advertiser to seed a search for suggesting targeting criteria for an ad. Using the seeds, the social networking system identifies a set of seed objects from a social graph. The social networking system traverses the social graph to compute the similarity between the seed objects and candidate objects related to the seed objects. Based on the computed similarity, the social networking system suggests a set of target objects to the advertiser. The social networking system receives a selection of one or more target objects from the advertiser. From the selected target objects the social networking system determines one or more targeting criteria for the ad, so users with an edge in the social graph to any of the selected target objects are eligible to receive the ad.

Abstract: A social networking system extends the reach of an ad by allowing an advertiser to seed a search for suggesting targeting criteria for an ad. Using the seeds, the social networking system identifies a set of seed objects from a social graph. The social networking system traverses the social graph to compute the similarity between the seed objects and candidate objects related to the seed objects. Based on the computed similarity, the social networking system suggests a set of target objects to the advertiser. The social networking system receives a selection of one or more target objects from the advertiser. From the selected target objects the social networking system determines one or more targeting criteria for the ad, so users with an edge in the social graph to any of the selected target objects are eligible to receive the ad.

Abstract: Compounds and compositions for treating disorders related to TRPA1 are described herein.

Abstract: Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.