Abstract: This invention relates to novel alkyne-bridged hetero-aromatics as described in the specification which are PDE10A inhibitors and useful for the treatment of neurological, psychiatric disorder, metabolic disorders, such as Schizophrenia, Parkinson's disease, Huntington's disease, Alzheimer's disease, learning memory disorder, drug addiction (abuse), sleeping disorder, depression, obesity, non-insulin dependent diabetes, bipolar disorder, obsessive compulsive disorder, or pain; to process for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.

Abstract: A social networking system infers a user's present interests based on the user's recent actions and/or the recent actions of the user's connections in the social networking system. The social networking system also determines a set of concepts associated with each of a set of information items, such as advertisements. By matching the user's present interests with the concepts associated with the information items, the social networking system selects one or more of the information items that are likely to be of present interest to the user. At least one of the matched interests and concepts are not identical. The social networking system then presents the selected information items for display to the user, thereby providing information based on an inferred temporal relevance of that information to the user.

Abstract: Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.

Abstract: This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.

Abstract: Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.

Abstract: A social networking system infers a user's present interests based on the user's recent actions and/or the recent actions of the user's connections in the social networking system. The social networking system also determines a set of concepts associated with each of a set of information items, such as advertisements. By matching the user's present interests with the concepts associated with the information items, the social networking system selects one or more of the information items that are likely to be of present interest to the user. The social networking system then presents the selected information items for display to the user, thereby providing information based on an inferred temporal relevance of that information to the user.

Abstract: This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.

Abstract: User profile information for a user of a social networking system is inferred based on information about user profile of the user's connections in the social networking system. The inferred user profile attributes may include age, gender, education, affiliations, location, and the like. To infer a value of a user profile attribute, the system may determine an aggregate value based on the attributes of the user's connections. A confidence score may also be associated with the inferred attribute value. The set of connections analyzed to infer a user profile attribute may depend on the attribute, the types of connections, and the interactions between the user and the connections. The inferred attribute values may be used to update the user's profile and to determine information relevant to the user to be presented to the user (e.g., targeting advertisements to the user based on the user's inferred attributes).

Abstract: This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.

Abstract: A social network targets advertisements to its members using inferential ad targeting. An inferential ad enables advertisers to reach members that do not meet targeting criteria for lack of information. A member's connections in the social network that satisfy the targeting criteria are leveraged to infer a targeted interest. An inferential ad is selected from a candidate set to be presented to the member. Varying complexities of targeting criteria, secondary inferential targeting criteria, and scopes of inference provide flexibility for inferential ad targeting in a social network.

Abstract: Applications in social networks support interaction between members through various types of channels such as email, notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of the number of messages allowed for an application for a channel.

Abstract: Applications in social networks support interaction between members through various types of channels such as notifications, newsfeed, and so forth. For each channel, applications are ranked based on their user affinity measures. User affinity is based on measuring positive and negative interactions by users as both senders and recipients of messages generated by applications. Metrics are computed for the different types of messages and interactions provided by applications. For each channel, an application receives user affinity score based on specific weighted combination of the metrics. Applications use channel resources to send messages to increase their user base. Given the large number of applications that are available, the extent to which applications are allowed to use channels is controlled, limiting their resource consumption. User affinity scores of applications calculated for a channel are used to decide the allocation of channel resources for an application.

Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.

Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.

Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.

Abstract: A method of operating a fuzzy inference system to simplify a mesh capable of producing a high-quality approximate mesh and retaining good characteristics and appearance so that a good visual effect emerges. The invention utilizes a fuzzy inference system to integrate mesh attributes and estimate the cost in removing certain data, which serve as a criteria for mesh simplification. Hence, the invention is suitable for progressive meshes, multiresolution modeling rendering and progressive transmission on a network.

Abstract: A texture partition and transmission method for network progressive transmission and real-time rendering by using the Wavelet Coding Algorithm is disclosed. An image to be applied on a mesh is firstly partitioned into multiple image tiles. After that, each image tile is further converted by the use of Wavelet Coding Algorithm to a data string that can represent multiple resolution levels of the image. Further, the mesh is also divided into multiple tiles to respectively correspond to the partitioned image tiles. After the feature parameter of each mesh tile is obtained, the rendering resolution of the image tile, which is intended to be pasted on the mesh tile, can be determined by the feature parameter.

Abstract: Compositions and methods are provided for dewaxing wax-embedded biological specimens prior to histochemical analysis. The compositions and methods provided can effectively remove wax or improved wax-based embedding materials, particularly paraffin-based, from specimens during preparation for histochemical or other diagnostic analyses, while minimizing danger to users, achieving compatibility with automated use, and maintaining compatibility with downstream histochemical analyses, particularly immunostaining. Compositions of the invention comprise a paraffin-solubilizing organic solvent, a polar organic solvent, and a surfactant. Compositions can further comprise water. The method involves contacting a wax-embedded specimen with the dewaxing composition to solubilize the wax impregnating the specimen prior to histochemical analysis.

Abstract: A method of constructing a progressive mesh using a forest clustering algorithm and all types of error evaluation, for maintaining a quality with a height similar to an original mesh. The method is capable of reducing any number of vertices or triangles in a single step so as to produce a progressive mesh that enables a smooth and fast change of the resolution. The mesh is applicable to both network transmission and real-time rendering.

Abstract: A method of operating a fuzzy inference system to simplify a mesh capable of producing a high-quality approximate mesh and retaining good characteristics and appearance so that a good visual effect emerges. The invention utilizes a fuzzy inference system to integrate mesh attributes and estimate the cost in removing certain data, which serve as a criteria for mesh simplification. Hence, the invention is suitable for progressive meshes, multiresolution modeling rendering and progressive transmission on a network.