Patents by Inventor Dominique Charmot

Dominique Charmot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ion binding compositions
    Patent number: 8445014
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 21, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Methods and compositions for treatment of ion imbalances
    Patent number: 8409561
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: August 16, 2010
    Date of Patent: April 2, 2013
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Futian Liu, Gerrit Klaerner
  • Crosslinked amine polymers
    Patent number: 8349305
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: January 8, 2013
    Assignee: Ilypsa, Inc.
    Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
  • Linear polyol stabilized polyfluoroacrylate compositions
    Patent number: 8337824
    Abstract: The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Grant
    Filed: August 22, 2009
    Date of Patent: December 25, 2012
    Assignee: Relypsa, Inc.
    Inventors: Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Ramakrishnan Chidambaram, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Jonathan Mills, Werner Strüver
  • COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS
    Publication number: 20120263670
    Abstract: The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.
    Type: Application
    Filed: June 29, 2011
    Publication date: October 18, 2012
    Applicant: Ardelyx, Inc.
    Inventors: Dominique Charmot, Jeffrey W. Jacobs, Michael Robert Leadbetter, Marc Navre, Christopher Carreras, Noah Bell
  • Ion binding polymers and uses thereof
    Patent number: 8287847
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: October 16, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
  • Ion binding polymers and uses thereof
    Patent number: 8282913
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: October 9, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Gerrit Klaerner
  • Ion binding compositions
    Patent number: 8282960
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 9, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, John Fordtran, Han Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Ion binding polymers and uses thereof
    Patent number: 8216560
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 10, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, John Fordtran, Gerrit Klaerner, Jerry M. Buysse, Robert Alpern, Mingjun Liu
  • Ion binding compositions
    Patent number: 8192758
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: June 5, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, John Fordtran, Han Ting Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Methods and compositions for treatment of ion imbalances
    Patent number: 8147873
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: April 3, 2012
    Assignee: Relypsa, Inc.
    Inventors: Dominique Charmot, Mingjun Liu
  • CROSSLINKED CATION EXCHANGE POLYMERS, COMPOSITIONS AND USE IN TREATING HYPERKALEMIA
    Publication number: 20110236340
    Abstract: The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group, pharmaceutical compositions of these polymers, compositions of a linear polyol and a salt of such polymer. Crosslinked cation exchange polymers having beneficial physical properties, including combinations of particle size, particle shape, particle size distribution, viscosity, yield stress, compressibility, surface morphology, and/or swelling ratio are also described. These polymers and compositions are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: August 22, 2009
    Publication date: September 29, 2011
    Applicant: Relypsa, Inc.
    Inventors: Paul Mansky, Detlef Albrecht, Michael Burdick, Han-Ting Chang, Dominique Charmot, Eric Connor, Sherin Halfon, I-Zu Huang, Mingjun Liu, Ramakrishnan Chidambaram, Jonathan Mills, Werner Strüver
  • ION BINDING POLYMERS AND USES THEREOF
    Publication number: 20110206631
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Application
    Filed: January 27, 2011
    Publication date: August 25, 2011
    Applicant: RELYPSA, INC.
    Inventors: Dominique Charmot, Han-Ting Chang, Gerrit Klaerner, Jerry M. Buysse, Mingjun Liu
  • METHODS AND COMPOSITIONS FOR TREATMENT OF ION IMBALANCES
    Publication number: 20110033505
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Application
    Filed: August 16, 2010
    Publication date: February 10, 2011
    Applicant: RELYPSA, INC.
    Inventors: Dominique Charmot, Han-Ting Chang, Mingjun Liu, Futian Liu, Gerrit Klaerner
  • Methods and compositions for treatment of ion imbalances
    Patent number: 7854924
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: December 21, 2010
    Assignee: Relypsa, Inc.
    Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
  • Methods and compositions for treatment of ion imbalances
    Patent number: 7776319
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: August 17, 2010
    Assignee: Relypsa, Inc.
    Inventors: Robert Alpern, Jerry Buysse, Han Ting Chang, Dominique Charmot, Michael James Cope, John Fordtran, Gerrit Klaerner, Eric Connor, Mingjun Liu, Futian Liu, Jun Shao
  • Crosslinked amine polymers
    Patent number: 7767768
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: August 3, 2010
    Assignee: Ilypsa, Inc.
    Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
  • Pharmaceutical compositions comprising crosslinked amine polymer with repeat units derived from polymerization of tertiary amines
    Patent number: 7754199
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
    Type: Grant
    Filed: April 11, 2007
    Date of Patent: July 13, 2010
    Assignee: Ilypsa, Inc.
    Inventors: Han Ting Chang, Dominique Charmot, Eric Connor, Florence Roger
  • Anion-binding polymers and uses thereof
    Patent number: 7718746
    Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: May 18, 2010
    Assignee: Ilypsa, Inc.
    Inventors: Eric Connor, Dominique Charmot, Han-Ting Chang, Florence Roger, Gerrit Klaerner, Son Hoai Nguyen, Jonathan Mills, Jerry M. Buysse, Angela Lee, Deidre Madsen, Jun Shao, Michael J. Cope, John Fordtran
  • CROSSLINKED POLYFLUOROACRYLIC ACID AND PROCESSES FOR THE PREPARATION THEREOF
    Publication number: 20100111892
    Abstract: The present invention is directed to crosslinked cation exchange polymers comprising a fluoro group and an acid group and being a polymerization product of at least three monomers. Pharmaceutical compositions of these polymers are useful to bind potassium in the gastrointestinal tract.
    Type: Application
    Filed: August 22, 2009
    Publication date: May 6, 2010
    Applicant: RELYPSA, INC.
    Inventors: Han-Ting Chang, Dominique Charmot, Mingjun Liu, Werner Strüver