Patents by Inventor Dominique Charmot

Dominique Charmot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF HYPERPHOSPHATEMIA USING CROSSLINKED SMALL MOLECULE AMINE POLYMERS
    Publication number: 20070110706
    Abstract: Anion-binding polymers are described. The anion-binding polymers in some cases are low swelling anion-binding polymers. In some cases, the anion-binding polymers have a pore volume distribution such that a fraction of the polymer is not available for non-interacting solutes above a certain percentage of the MW of the target ion for the polymer. In some cases, the anion-binding polymers are characterized by low ion-binding interference, where the interference is measured in, for example, a gastrointestinal simulant, relative to non-interfering buffer. Pharmaceutical composition, methods of use, and kits are also described.
    Type: Application
    Filed: August 17, 2006
    Publication date: May 17, 2007
    Inventors: Eric Connor, Dominique Charmot, Han Chang, Florence Roger, Gerrit Klaemer, Son Hoai
  • Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
    Patent number: 7205161
    Abstract: Sensors for determining the presence and concentration of biomolecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface modified with a hydrophobic polymer segment, attached to which is a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, which allows for controlled architecture polymers to modify the surface of the substrate, and the use of monomers possessing functional groups which do not require activation prior to probe attachment. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: April 17, 2007
    Assignee: Symyx Technologies, Inc.
    Inventors: Gerrit Klaerner, Didier Benoit, Dominique Charmot, Srinivas Nomula, Marcelo Eduardo Piotti, Laura T. Mazzola
  • Laundry treatment compositions comprising a polymer with a cationic and polydialkylsiloxane moiety
    Patent number: 7179777
    Abstract: A laundry treatment composition comprising at least one polymeric material comprising a cationic polymer moiety and a polydialkylsiloxane moiety, and at least one other component.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: February 20, 2007
    Assignee: Unilever Home & Personal Care USA Division of Conopco, Inc.
    Inventors: Wilfried Blokzijl, Robert John Carswell, Dominique Charmot, Robert Alan Hunter, Mingjun Liu, Paul Mansky, Victor Nava-Salgado, Giovanni Francesco Unali
  • Photoresist polymer compositions
    Publication number: 20060257781
    Abstract: The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
    Type: Application
    Filed: December 12, 2005
    Publication date: November 16, 2006
    Inventors: Didier Benoit, Adam Safir, Han-Ting Chang, Dominique Charmot, Isao Nishimura, Akimasa Soyano, Kenji Okamoto, Yong Wang
  • Photoresist polymers
    Publication number: 20060217519
    Abstract: The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
    Type: Application
    Filed: December 12, 2005
    Publication date: September 28, 2006
    Inventors: Didier Benoit, Adam Safir, Han-Ting Chang, Dominique Charmot, Kenji Okamoto, Isao Nishimura, Yong Wang
  • Methods of making ABA-type block copolymers having a random block of hydrophobic and hydrophilic monomers
    Patent number: 7067586
    Abstract: Block copolymers are prepared by living-type or semi-living type free radical polymerization, with said copolymers having at least one random block comprised of at least one hydrophobic monomer and at least one hydrophilic monomer. The selection of hydrophobic and hydrophilic monomers in the random block is determined by the relative hydrophobicity of the monomers to impart selected solubility or dispersability in water and/or alcohols of the overall block copolymer.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: June 27, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Mingjun Liu, Damian Hajduk, Jean M. J. Frechet, Ezat Khoshdel, Ralph B. Nielsen, Dominique Charmot
  • Controlled-architecture polymers and use thereof as separation media
    Publication number: 20060128917
    Abstract: Controlled architecture polymers made preferably with acrylamide type monomers are prepared in living-type or semi-living-type free radical polymerizations, with the architecture preferably being other than linear, such as star, branched, grafted or hyper-branched. The controlled architecture polymers have high weight average molecular weights and low viscosities, which make they particularly useful in replaceable capillary electrophoresis separation media for biological molecules, such as DNA fragments.
    Type: Application
    Filed: February 10, 2004
    Publication date: June 15, 2006
    Inventors: Gerrit Klaerner, Miroslav Petro, Dominique Charmot, Didier Benoit
  • Synthesis of photoresist polymers
    Publication number: 20060122346
    Abstract: The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
    Type: Application
    Filed: June 25, 2004
    Publication date: June 8, 2006
    Inventors: Didier Benoit, Adam Safir, Han-Ting Chang, Dominique Charmot, Kenji Okamoto, Isao Nishimura, Yong Wang
  • Home and personal care compositions comprising silicon-based lubricants
    Publication number: 20060100126
    Abstract: A composition for personal, home, or laundry treatment comprising a polymer made up of one or more crosslinked rake or comb silicone copolymer segments. A process for making copolymers for use in such compositions involves hydrosilylation in the presence of a catalyst.
    Type: Application
    Filed: December 29, 2003
    Publication date: May 11, 2006
    Inventors: Andrew Avery, Dominique Charmot, Jean Frechet, Damian Hajduk, Ezat Khoshdel, Mingjun Liu
  • Toxin binding compositions
    Publication number: 20060099169
    Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.
    Type: Application
    Filed: October 13, 2005
    Publication date: May 11, 2006
    Applicant: Ilypsa, Inc.
    Inventors: Dominique Charmot, Jerry Buysse, Han Chang, Michael Cope, Tony Mong, Elizabeth Goka
  • Cellulose copolymers that modify fibers and surfaces and methods of making same
    Patent number: 7030187
    Abstract: Cellulosic polymers, copolymers and grafts, are disclosed that adhere to fibers and surfaces during an aqueous treatment process. The cellulosic polymers having grafts and/or co-blocks are prepared using living-type free radical polymerization techniques, which provides control over the degree of substitution and graft/co-block composition and structure. These cellulosic polymers allow for the modification of fibers and surfaces to provide a desired effect.
    Type: Grant
    Filed: September 28, 2004
    Date of Patent: April 18, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Dominique Charmot, Manikandan Jayaraman, Han Ting Chang, Paul Mansky, Wilfried Blokzijl
  • Toxin binding compositions
    Publication number: 20060078534
    Abstract: Methods and compositions for the treatment of toxin-mediated diseases are provided herein. One aspect of the invention is oligosaccharide-based therapeutics that interact with toxins and methods of uses thereof. In one embodiment the oligosaccharide-based therapeutics of the invention comprise polymeric particles with attached oligosaccharide binding moieties. The compositions of the invention can be used in the treatment of toxin-mediated diseases such as antibiotic-associated diarrhea and pseudomembranous colitis, including Clostridium difficile associated diarrhea.
    Type: Application
    Filed: October 13, 2004
    Publication date: April 13, 2006
    Inventors: Dominique Charmot, Jerry Buysse, Han Chang, Tony Mong, Michael Cope, Elizabeth Goka
  • Cleaving and replacing thio control agent moieties from polymers made by living-type free radical polymerization
    Patent number: 7012119
    Abstract: A method of free radical polymerization and for cleaving a thio group from the resulting polymer is provided. The method comprises forming a mixture of one or more monomers, at least one free radical source and a control agent, wherein the control agent comprises a thio moiety. The mixture is polymerized, and the resulting polymer is mixed with a free radical source, and optionally an addition fragmentation agent under cleavage conditions. The thio moiety on the polymer is replaced with a group of interest.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: March 14, 2006
    Assignee: Symyx Technologies, Inc.
    Inventors: Dominique Charmot, Han Ting Chang, Wenyue Wang, Marcelo Piotti
  • Ion binding compositions
    Publication number: 20060024336
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 2, 2006
    Inventors: Dominique Charmot, John Fordtran, Han Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Methods and compositions for treatment of ion imbalances
    Publication number: 20060024265
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodium-binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Application
    Filed: March 30, 2005
    Publication date: February 2, 2006
    Inventors: Robert Alpern, Jerry Buysse, Han Chang, Dominique Charmot, Michael Cope, John Fordtran, Gerrit Klaerner
  • Modulation of lysophosphatidylcholine and treatment of diet-induced conditions
    Publication number: 20050288255
    Abstract: The present invention provides methods for the treatment of lysophosphatidylcholine-related conditions. In particular, the invention provides a method of treating an insulin-related condition, e.g., diabetes or diabetes type 2, and/or a weight-related-condition, e.g., unwanted weight gain or obesity, in an animal subject by reducing production, absorption and/or activity of lysophosphatidylcholine. Further, the beneficial effects of reducing lysophosphatidylcholine in terms of diabetes and weight gain are disclosed.
    Type: Application
    Filed: May 3, 2005
    Publication date: December 29, 2005
    Inventors: David Hui, Dominique Charmot, Jerry Buysse
  • Phospholipase inhibitors localized in the gastrointestinal lumen
    Publication number: 20050244367
    Abstract: The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.
    Type: Application
    Filed: May 3, 2004
    Publication date: November 3, 2005
    Applicant: Ilypsa, Inc.
    Inventors: David Hui, Dominique Charmot, Jerry Buysse
  • Crosslinked amine polymers
    Publication number: 20050239901
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides polymeric and pharmaceutical compositions comprising crosslinked amine polymers. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of renal diseases and hyperphosphatemia.
    Type: Application
    Filed: March 22, 2005
    Publication date: October 27, 2005
    Inventors: Han Chang, Dominique Charmot, Eric Connor, Florence Roger
  • Ion binding compositions
    Publication number: 20050220890
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides core-shell compositions and pharmaceutical compositions thereof. Methods of use of the core-shell compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of phosphate imbalance disorders, hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
    Type: Application
    Filed: March 30, 2004
    Publication date: October 6, 2005
    Applicant: Symyx Therapeutics, Inc.
    Inventors: Dominique Charmot, John Fordtran, Han Chang, Eric Connor, Mingjun Liu, Gerrit Klaerner
  • Ion binding polymers and uses thereof
    Publication number: 20050220751
    Abstract: The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
    Type: Application
    Filed: October 13, 2004
    Publication date: October 6, 2005
    Inventors: Dominique Charmot, Han Chang, Gerrit Klaerner, Michael Cope, Mingjun Liu, Futian Liu