Patents by Inventor Donald S. Karanewsky

Donald S. Karanewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF QPCTL AND QPCT
    Publication number: 20240101544
    Abstract: Provided herein are compounds of formula (I) and formula (II) that are inhibitors of QPCTL and QPCT: Also provided are pharmaceutical compositions comprising the compounds, and methods for using the compounds for the treatment of disease.
    Type: Application
    Filed: July 20, 2023
    Publication date: March 28, 2024
    Inventors: James M. Veal, Jeffrey A. Stafford, Donald S. Karanewsky, Shyama Herath
  • Substituted imidazo[1,2-a]quinazolines and imidazo [1,2-a]pyrido[4,3-e]pyrimidines as inhibitors of PARG
    Patent number: 11939335
    Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: March 26, 2024
    Assignee: 858 THERAPEUTICS, INC.
    Inventors: James M. Veal, Jeffrey A. Stafford, Donald S. Karanewsky, Shyama Herath
  • INHIBITORS OF PARG
    Publication number: 20230374022
    Abstract: Provided herein are inhibitors of PARG, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the PARG inhibitory compounds for the treatment of disease.
    Type: Application
    Filed: May 19, 2023
    Publication date: November 23, 2023
    Inventors: James M. VEAL, Jeffrey A. STAFFORD, Donald S. KARANEWSKY, Shyama HERATH
  • Processes and intermediates for making sweet taste enhancers
    Patent number: 10570105
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (XI): wherein Y is C1-C12 alkylene or C1-C12 alkenylene; and R8 and R12 are independently C1-C12 alkyl.
    Type: Grant
    Filed: May 9, 2019
    Date of Patent: February 25, 2020
    Assignee: Firmenich Incorporated
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
    Publication number: 20190263762
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (XI): wherein Y is C1-C12 alkylene or C1-C12 alkenylene; and R8 and R12 are independently C1-C12 alkyl.
    Type: Application
    Filed: May 9, 2019
    Publication date: August 29, 2019
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • Processes and intermediates for making sweet taste enhancers
    Patent number: 10308621
    Abstract: The present invention includes methods/processes and intermediates for preparing sulfamoyl chloride:
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: June 4, 2019
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
    Publication number: 20180370931
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • Processes and intermediates for making sweet taste enhancers
    Patent number: 10087154
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: October 2, 2018
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • SWEETENER COMPOSITION
    Publication number: 20180086751
    Abstract: Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products. The formulations include combinations of any one or more sweetener in combination with any one or more flavor modifying compound described or referenced herein.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 29, 2018
    Inventors: Donald S. Karanewsky, Catherine Tachdjian, Guy Servant, Tanya Ditschun
  • Sweet flavor modifier
    Patent number: 9902737
    Abstract: The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: February 27, 2018
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Xiao Qing Tang, Donald S. Karanewsky, Guy Servant, Xiaodong Li, Feng Zhang, Qing Chen, Hong Zhang, Timothy Davis, Vincent Darmohusodo, Melissa S. Wong, Victor Selchau
  • SWEETENER COMPOSITION
    Publication number: 20170354175
    Abstract: Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products.
    Type: Application
    Filed: May 15, 2017
    Publication date: December 14, 2017
    Inventors: Donald S. Karanewsky, Catherine Tachdjian, Guy Servant, Tanya Ditschun
  • Sweet flavor modifier
    Patent number: 9834544
    Abstract: The present invention includes compounds having structural formula (I), or salts or solvates thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of compositions.
    Type: Grant
    Filed: July 22, 2014
    Date of Patent: December 5, 2017
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Xiao Qing Tang, Donald S. Karanewsky, Guy Servant, Xiaodong Li, Feng Zhang, Qing Chen, Hong Zhang, Timothy James Davis, Vincent Darmohusodo, Melissa S. Wong, Victor Selchau
  • PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
    Publication number: 20170327479
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Application
    Filed: July 31, 2017
    Publication date: November 16, 2017
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • Processes and intermediates for making sweet taste enhancers
    Patent number: 9732052
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: August 15, 2017
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER
    Publication number: 20170119033
    Abstract: Disclosed herein are stabilized sweet enhancer compositions. Also disclosed herein are methods for stabilizing sweet enhancers.
    Type: Application
    Filed: April 25, 2016
    Publication date: May 4, 2017
    Inventors: Hanghui Liu, Donald S. Karanewsky, Nathan Faber
  • SWEETENER AND FLAVOR ENHANCER FORMULATIONS
    Publication number: 20170105432
    Abstract: Formulations comprising one or more sweetener and one or more flavor modifying compound are provided herein, wherein the formulation is provided for use in ingestible products, such as food or beverage products or pharmaceutical, or for use in non-comestible products, such as cosmetic or hygienic products.
    Type: Application
    Filed: October 16, 2015
    Publication date: April 20, 2017
    Inventors: Donald S. Karanewsky, Catherine Tachdjian, Guy Servant
  • TOPICAL COMPOSITIONS COMPRISING MODULATORS OF TRPM8
    Publication number: 20160339026
    Abstract: The present disclosure relates to topical compositions comprising one or more compounds which are cooling agents.
    Type: Application
    Filed: October 2, 2015
    Publication date: November 24, 2016
    Inventors: Alain Noncovich, Jane Ung, Timothy Davis, Joseph R. Fotsing, Rachel D.A. Kimmich, Chad Priest, Donald S. Karanewsky, Lyudmyla Chumakova, Andrew Patron, Paul Brust, Guy Servant
  • PROCESSES AND INTERMEDIATES FOR MAKING SWEET TASTE ENHANCERS
    Publication number: 20160289200
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Application
    Filed: June 16, 2016
    Publication date: October 6, 2016
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin
  • SWEET FLAVOR MODIFIER
    Publication number: 20160251372
    Abstract: The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.
    Type: Application
    Filed: March 2, 2016
    Publication date: September 1, 2016
    Inventors: Catherine Tachdjian, Xiao Qing Tang, Donald S. Karanewsky, Guy Servant, Xiaodong Li, Feng Zhang, Qing Chen, Hong Zhang, Timothy Davis, Vincent Darmohusodo, Melissa Wong, Victor Selchau
  • Processes and intermediates for making sweet taste enhancers
    Patent number: 9382196
    Abstract: The present invention includes methods/processes and intermediates for preparing compounds having structural Formula (I): wherein X is alkyl, substituted alkyl, alkenyl, substituted alkenyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: July 5, 2016
    Assignee: Senomyx, Inc.
    Inventors: Catherine Tachdjian, Donald S. Karanewsky, Xiao-Qing Tang, Qing Chen, Peter Leeming, Tayyab Rashid, Daniel Levin