Patents by Inventor Donald S. Karanewsky

Donald S. Karanewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (Substituted)Acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20040259804
    Abstract: This invention is directed to novel (substituted) acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: July 20, 2001
    Publication date: December 23, 2004
    Inventor: Donald S. Karanewsky
  • 5-Substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds
    Publication number: 20040152717
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Application
    Filed: October 10, 2003
    Publication date: August 5, 2004
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Bijan Pedram, Donald S. Karanewsky
  • Treatment of kidney disease or renal failure using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
    Publication number: 20040058850
    Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: September 2, 2003
    Publication date: March 25, 2004
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • Treatment of inflammation-associated disorders using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors
    Patent number: 6693096
    Abstract: The present invention provides methods and compositions for preventing and treating inflammation-associated disorders or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: February 17, 2004
    Assignee: IDUN Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20030232788
    Abstract: This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: February 7, 2003
    Publication date: December 18, 2003
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Vincent J. Kalish, Edward D. Robinson, Brett R. Ullman
  • Treatment of infectious disease using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
    Publication number: 20030186842
    Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: July 29, 2002
    Publication date: October 2, 2003
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • Treatment of infectious disease using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors
    Patent number: 6610683
    Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: August 26, 2003
    Assignee: IDUN Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases
    Publication number: 20030119748
    Abstract: This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.
    Type: Application
    Filed: September 30, 2002
    Publication date: June 26, 2003
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Xu Bai
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6544951
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: April 8, 2003
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Robert J. Ternansky
  • Inhibition of inflammation using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors
    Patent number: 6531467
    Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: March 11, 2003
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai, Dominic F. Montisano, David Higgins
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Publication number: 20020183314
    Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Application
    Filed: February 22, 2002
    Publication date: December 5, 2002
    Applicant: Ligand Pharmaceuticals Incorporated
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky, Anthony W. Thompson, Thomas R. Caferro, Neelakandha S. Mani, Jyun-Hung Chen, Marquis L. Cummings, James P. Edwards, Mark E. Adams, Charlotte L.F. Deckhut
  • C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 6489353
    Abstract: This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: December 3, 2002
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Xu Bai
  • Inhibition of apoptosis using interleukin-1beta converting enzyme (ICE)/CED-3 family inhibitors
    Publication number: 20020147171
    Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: February 25, 2002
    Publication date: October 10, 2002
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • TREATMENT OF INFECTIOUS DISEASE USING INTERLEUKIN-1BETA-CONVERTING ENZYME (ICE)/CED-3 FAMILY INHIBITORS
    Publication number: 20020128306
    Abstract: The present invention provides methods and compositions for treating infectious disease or suppressing inflammation associated therewith or ameliorating symptoms thereof by the suppression of the activity of a member of the interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family of proteases. Also provided are compositions useful for these purposes. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: November 13, 2001
    Publication date: September 12, 2002
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai
  • Inhibition of inflammation using interleukin-1beta-converting enzyme (ICE)/CED-3 family inhibitors
    Publication number: 20020123522
    Abstract: The present invention provides methods for expanding and increasing survival of hematopoietic cell populations, for prolonging viability of an organ for transplantation, and enhancing bioproduction, using interleukin-1&bgr;-converting enzyme (ICE)/CED-3 family inhibitors. Exemplary compounds useful in the methods of the invention are provided herein.
    Type: Application
    Filed: October 16, 2001
    Publication date: September 5, 2002
    Applicant: Idun Pharmaceuticals, Inc.
    Inventors: Lawrence C. Fritz, Kevin J. Tomaselli, Donald S. Karanewsky, Steven D. Linton, Xu Bai, Dominic F. Montisano, David Higgins
  • Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Patent number: 6444663
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: September 3, 2002
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Steven D. Linton
  • (Substituted)acyl dipeptidyl inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20020091089
    Abstract: This invention is directed to novel (substituted)acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: April 16, 2001
    Publication date: July 11, 2002
    Inventors: Donald S. Karanewsky, Vincent J. Kalish, Edward D. Robinson, Brett R. Ullman
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases
    Publication number: 20020042376
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: January 16, 2001
    Publication date: April 11, 2002
    Inventors: Donald S. Karanewsky, Robert J. Ternansky, Steven D. Linton, Thang Dinh
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20020028774
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Application
    Filed: December 19, 2000
    Publication date: March 7, 2002
    Inventors: Donald S. Karanewsky, Robert J. Ternansky
  • C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Publication number: 20020025935
    Abstract: This invention is directed to novel (N-substituted) indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory. autoimmune and neurodegenerative diseases, for the prevention of ischemic injury.
    Type: Application
    Filed: December 20, 2000
    Publication date: February 28, 2002
    Inventors: Donald S. Karanewsky, Xu Bai