Patents by Inventor Donald S. Karanewsky

Donald S. Karanewsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS
    Publication number: 20090220662
    Abstract: The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
    Type: Application
    Filed: March 3, 2009
    Publication date: September 3, 2009
    Inventors: Catherine TACHDJIAN, Donald S. Karanewsky, Sara L. Adamski-Werner, Jeffrey M. Yamamoto, Guy Servant
  • Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
    Patent number: 7563894
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 21, 2009
    Assignees: IRM LLC, Novartis AG
    Inventors: Valentina Molteni, Shuli You, Juliet Nabakka, Yi Liu, Xiaolin Li, Donatella Chianelli, Jon Loren, Xiaodong Liu, Shifeng Pan, Donald S. Karanewsky, Pascal Furet, Vito Guagnano
  • INHIBITORS OF CATHEPSIN S
    Publication number: 20090137570
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Application
    Filed: January 28, 2009
    Publication date: May 28, 2009
    Applicant: IRM LLC
    Inventors: Hong LIU, Arnab K. CHATTERJEE, David C. TULLY, Phillip B. ALPER, Badry BURSULAYA, Jianhua GUO, David H. WOODMANSEE, Daniel MUTNICK, Donald S. KARANEWSKY, Yun HE
  • Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
    Patent number: 7514447
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: April 7, 2009
    Assignees: IRM LLC, Novartis AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Jon Loren, Juliet Nabakka, Xiadong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • Inhibitors of cathepsin s
    Patent number: 7507755
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: March 24, 2009
    Assignee: IRM LLC
    Inventors: Hong Liu, Phillip B. Alper, Donald S. Karanewsky
  • Inhibitors of cathepsin S
    Patent number: 7501408
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula (I): wherein Q is thiomorpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: March 10, 2009
    Assignee: IRM LLC
    Inventors: Hong Liu, Arnab Chatterjee, David C. Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David H. Woodmansee, Daniel Mutnick, Donald S. Karanewsky, Yun He
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20090012094
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: January 8, 2009
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Jon Loren, Juliet Nabakka, Xiaodong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • Mineralocorticoid receptor modulator compounds, processes for their preparation, and their uses
    Patent number: 7442696
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1 —R10 are as defined herein.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: October 28, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Robert I. Higuchi, Lin Zhi, Mark E. Adams, Yan Liu, Donald S. Karanewsky
  • Mineralocorticoid receptor modulator compounds and methods, and pharmaceutical compositions containing these compounds
    Patent number: 7435733
    Abstract: This invention relates to compounds that bind to mineralocorticoid receptors and/or modulate activity of mineralocorticoid receptors, and to methods for making and using such compounds. Some embodiments relate to compounds of Formula I: or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, wherein R1-R10 are as defined herein.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: October 14, 2008
    Assignee: Ligand Pharmaceuticals, Inc.
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080167308
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 10, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Juliet Nabakka, Jon Loren, Xiaodong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080139559
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS
    Inventors: Valentina Molteni, Shuli You, Juliet Nabakka, Yi Liu, Xiaolin Li, Donatella Chianelli, Jon Loren, Xiaodong Liu, Shifeng Pan, Donald S. Karanewsky, Pascal Furet, Vito Guagnano
  • DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
    Publication number: 20080139597
    Abstract: Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicants: IRM LLC, A DELAWARE LIMITED LIABILITY COMAPNY, NOVARTIS, AG
    Inventors: Valentina Molteni, Xiaolin Li, Donatella Chianelli, Jon Loren, Juliet Nabakka, Xiaodong Liu, Shifeng Pan, Yi Liu, Donald S. Karanewsky, Pascal Furet, Vito Guagnano, Shuli You
  • Inhibitors of cathepsin S
    Patent number: 7314872
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula I: wherein Q is morpholinyl; and A, R5, R6, R7, R8, R9 and Ar are substituents.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: January 1, 2008
    Assignee: IRM LLC
    Inventors: Hong Liu, Arnab Chatterjee, David C. Tully, Phillip Alper, Badry Bursulaya, Jianhua Guo, David H. Woodmansee, Daniel Mutnick, Donald S. Karanewsky, Yun He
  • Inhibitors of cathepsin S
    Patent number: 7256207
    Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
    Type: Grant
    Filed: August 18, 2004
    Date of Patent: August 14, 2007
    Assignee: IRM LLC
    Inventors: Hong Liu, Phillip B. Alper, Donald S. Karanewsky
  • Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
    Patent number: 7214690
    Abstract: Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation and their uses are described.
    Type: Grant
    Filed: February 22, 2002
    Date of Patent: May 8, 2007
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Robert I. Higuchi, Lin Zhi, Donald S. Karanewsky, Anthony W. Thompson, Thomas R. Caferro, Neelakandha S. Mani, Jyun-Hung Chen, Marquis L. Cummings, James P. Edwards, Mark E. Adams, Charlotte L. F. Deckhut
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 7183260
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: February 27, 2007
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S Karanewsky, Robert J Ternansky, Steven D Linton, Thang Dinh
  • 5-substituted 7,9-difluoro-5H-chromeno[3,4-f]quinoline compounds as selective progesterone receptor modulator compounds
    Patent number: 7163946
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by progesterone receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: January 16, 2007
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Bijan Pedram, Donald S. Karanewsky
  • (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
    Patent number: 7157430
    Abstract: This invention is directed to novel (substituted) acyl dipeptidyl ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: January 2, 2007
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S Karanewsky, Vincent J Kalish, Edward D Robinson, Brett R Ullman
  • 5-cycloalkenyl 5H-chromeno[3,4-f]quinoline derivatives as selective progesterone receptor modulator compounds
    Patent number: 7071205
    Abstract: The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by Progesterone Receptor. Also provided are methods of making such compounds and pharmaceutical compositions.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: July 4, 2006
    Assignee: Ligand Pharmaceuticals Incorporated
    Inventors: Lin Zhi, Cornelis Arjan Van Oeveren, Bijan Pedram, Donald S. Karanewsky
  • C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
    Patent number: 7053056
    Abstract: This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: May 30, 2006
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Robert J. Ternansky, Steven D. Linton, Thang Dinh