Abstract: The present application relates to a semiconductor device, comprising a substrate, with a body region being formed on the substrate, and a well region being formed in the body region; and further comprising trenches penetrating through the well region and the body region and extending to the substrate, wherein a first polysilicon body and a second polysilicon body, which are isolated from each other, are respectively formed at the bottom and the top of each trench to form a split gate structure, the trenches are filled with an inter-layer dielectric layer, a conductive plug penetrating through the inter-layer dielectric layer and extending into the first polysilicon body is formed in each trench, the conductive plug is isolated from the second polysilicon body by means of the inter-layer dielectric layer, the conductive plug is connected to a source electrode, and the second polysilicon body is connected to a gate electrode.

Abstract: Provided herein is a combination product comprising a Bcl-2 inhibitor and an MDM-2 inhibitor, the combination product providing a use in the prevention and/or treatment of diseases (e.g., cancer).

Abstract: The present invention pertains to the biomedical field, and particularly relates to a method for treating or suppressing a cancer, reducing its severity, lowering its risk or inhibiting its metastasis in an individual. The method comprises administering to the individual a therapeutically effective amount of one or more of a FAK inhibitor, an ALK inhibitor and a ROS1 inhibitor, and a therapeutically effective amount of an EGFR inhibitor. The invention also relates to a pharmaceutical composition or kit comprising one or more of a FAK inhibitor, an ALK inhibitor and a ROS1 inhibitor, and an EGFR inhibitor.

Abstract: The present disclosure pertains to the field of biomedicine, and specifically relates to a method for treating, suppressing, reducing the severity of, lowering the risk of, or inhibiting the metastasis of cancer in an individual, the method comprising administering to the individual a therapeutically effective amount of an IAP inhibitor, a therapeutically effective amount of a modulator of an immune checkpoint molecule, and optionally a therapeutically effective amount of a tubulin inhibitor. The present disclosure further relates to a pharmaceutical composition or kit comprising an IAP inhibitor, a modulator of an immune checkpoint molecule, and optionally a tubulin inhibitor.

Abstract: Provided are biomarkers for predicting the efficacy of MDM2 inhibitors in treating cancer patients. Also provided are compositions, e.g., kits, for evaluating the biomarkers and methods of using the biomarkers to predict a cancer patient's response to the MDM2 inhibitors. Such information can be used in determining prognosis and treatment options for cancer patients.

Abstract: A metal wiring method for reducing gate resistance of a narrow control gate structure, wherein the gate structure is etched with first gate electrodes and second gate electrodes at regular intervals and kept with complete gate electrodes at regular intervals, thereby constituting a structure in which the first and second gate electrodes and the complete gate electrodes are spaced apart. A first contact hole is etched on the complete gate electrode to draw out metal as a first metal layer. A second contact hole is etched on a source region and a split gate to draw out metal as a second metal layer. These two metal layers are separated by a dielectric layer. A multi-point contact of the first layer of metal with the gate electrode in a Y direction reduces the gate resistance caused by an excessively long path in the Y direction of a control gate electrode.

Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.

Abstract: Disclosed is a pharmaceutical composition comprising (i) a compound of formula (I) or a pharmaceutically acceptable salt thereof; (ii) a CDK inhibitor or a pharmaceutically acceptable salt thereof, for the prevention and/or treatment of a disease mediated by Bcl-2 and/or CDK activity.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. Two metal sheets are arranged at two sides of the tongue portion. Each of the metal sheets includes a hook structure protruding from a side portion of the tongue portion and a through hole adjacent to the hook structure. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The metallic shell includes a receptacle cavity. The insulated housing is held in the receiving cavity. The contact arms are formed by the through holes of the metal sheets in an elastic manner, to avoid the hooks on both sides of the electrical plug connector in contact with the metal sheets in a poor interference manner.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. A coverage region adjacent to the base portion is held on a surface of the tongue portion. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The receptacle terminals include a body portion and a contact portion, the body portion is held in the base portion and the tongue portion, and the contact portion is outwardly extending from one end of the body portion. Each of the receptacle terminals includes an avoidance portion between the contact portion and the body portion. The avoidance portion of each of the receptacle terminals is covered by the coverage region of the tongue portion.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The metallic shell includes a receptacle cavity, the insulated housing is held in the receptacle cavity. An insertion opening is on a first end of the metallic shell, a stopping portion is inwardly bending on a second end of the metallic shell, and the stopping portion is extending to a surface of the base portion. When an electrical plug connector is inserted into the receptacle cavity, an end portion of the electrical plug connector is in contact with the stopping portion.

Abstract: There is a need for more effective and efficient predictive data analysis solutions that utilize categorical input data objects. This need can be addressed by, for example, solutions for performing predictive inference using a categorical inference machine learning engine. In one example, a method includes receiving categorical input data objects, generating, based on each particular categorical input data object and using embedding layers, embedded feature representations for the particular categorical input data object; generating, based on each particular embedded feature representation and using initial capsule layers; initial instantiation parameters for the corresponding categorical data object; generating, based on each initial instantiation parameter and using subsequent capsule layers, inferred instantiation parameters for categorical input data objects; and generating predictions based at least in part on the inferred instantiation parameters.

Abstract: The present disclosure provides a pharmaceutical composition comprising a Bcl-2/Bcl-xL inhibitor, a chemotherapeutic agent, and a pharmaceutically acceptable carrier. The present disclosure also provides a method of treating cancer, comprising administering to a subject in need thereof a therapeutically effective amount of a Bcl-2/Bcl-xL inhibitor and a therapeutically effective amount of a chemotherapeutic agent. The present disclosure also provides use of a combination of a Bcl-2/Bcl-xL inhibitor and a chemotherapeutic agent in the manufacture of an anti-tumor medicament. In the present disclosure, a significantly enhanced anti-tumor effect can be achieved by administration of a Bcl-2/Bcl-xL inhibitor in combination with a chemotherapeutic agent.

Abstract: A light shield for a ring light, to reduce abnormal images occurring because of errant and uncontrolled light entering an image-capturing module, includes a first shield portion, a second shield portion, and a third shield portion. The first shield portion is on an exterior of the light shield. The third shield portion is on an interior of the shield. The second shield portion is arranged between the first shield portion and the third shield portion and is inclined relative to the first and third shield portions. The light shield controls the direction of light emitted from the ring light, allowing an adjacent camera module or other image-capturing device to function normally and accurately. The disclosure further provides a lamp assembly including the light shield.

Abstract: A method for manufacturing a trenched split-gate device, comprising: etching a semiconductor substrate to form a trench (120); depositing an oxide in the trench to form a floating-gate oxide layer in which the floating-gate oxide layer gradually thickens from top to bottom along a side wall of the trench, and a thickness of the floating gate oxide layer at a lower part of the side wall of the trench is the same as that of the floating gate oxide layer at a bottom of the trench; depositing polysilicon into the trench to form a floating-gate polysilicon layer (123); growing an insulation medium on an upper surface of the floating-gate polysilicon layer to form an isolation layer (124); and forming a control gate on the isolation layer in the trench.

Abstract: Disclosed is a pharmaceutical composition comprising (i) a compound of formula (I) or a pharmaceutically acceptable salt thereof; (ii) a CDK inhibitor or a pharmaceutically acceptable salt thereof, for the prevention and/or treatment of a disease mediated by MDM2 and/or CDK activity.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. Two metal sheets are arranged at two sides of the tongue portion. Each of the metal sheets includes a hook structure protruding from a side portion of the tongue portion and a through hole adjacent to the hook structure. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The metallic shell includes a receptacle cavity. The insulated housing is held in the receiving cavity. The contact arms are formed by the through holes of the metal sheets in an elastic manner, to avoid the hooks on both sides of the electrical plug connector in contact with the metal sheets in a poor interference manner.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The metallic shell includes a receptacle cavity, the insulated housing is held in the receptacle cavity. An insertion opening is on a first end of the metallic shell, a stopping portion is inwardly bending on a second end of the metallic shell, and the stopping portion is extending to a surface of the base portion. When an electrical plug connector is inserted into the receptacle cavity, an end portion of the electrical plug connector is in contact with the stopping portion.

Abstract: Green, fast and easy evaporating organic solvent for use as a lubricant in the processing of polytetrafluoroethylene (PTFE) and expanded polytetrafluoroethylene (ePTFE) products and processes of using the solvents to fabricate the products are disclosed herein. The products can be used in the field of bio- and medical applications, such as for use in vascular grafts, cardiovascular and soft tissue patches, facial implants, surgical sutures, and endovascular prosthesis, and for any products known in the aerospace, electronics, fabrics, filtration, industrial and sealant arts.

Abstract: An electrical receptacle connector includes an insulated housing, receptacle terminals, and a metallic shell. The insulated housing includes a base portion and a tongue portion outwardly extending from the base portion. A coverage region adjacent to the base portion is held on a surface of the tongue portion. The receptacle terminals are held in the base portion and disposed at the surface of the tongue portion. The receptacle terminals include a body portion and a contact portion, the body portion is held in the base portion and the tongue portion, and the contact portion is outwardly extending from one end of the body portion. Each of the receptacle terminals includes an avoidance portion between the contact portion and the body portion. The avoidance portion of each of the receptacle terminals is covered by the coverage region of the tongue portion.