Patents by Inventor Dong Fang

Dong Fang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS
    Publication number: 20140200329
    Abstract: The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 17, 2014
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David J. YANG, Chun W. LIU, Dong-Fang YU, E. Edmund KIM
  • Compositions and methods for cellular imaging and therapy
    Patent number: 8758723
    Abstract: The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4 compounds and derivatives.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: June 24, 2014
    Assignee: The Board of Regents of the University of Texas System
    Inventors: David J. Yang, Chang-Sok Oh, Dong-Fang Yu, Ali Azhdarinia, Saady Kohanim
  • Communication method and server of transmission control protocol
    Patent number: 8750308
    Abstract: This disclosure provides methods and servers to transmit data packets via Transmission Control Protocol (TCP) connections. In some aspects, transmitting data packets includes receiving a data packet from a first application on a first server. The data packet is analyzed to determine a destination address associated with a second server. The data packet is transmitted based on the address associated with the second server. In some aspects, transmitting data packets includes receiving a data packet from a second application on a second server. The data packet is analyzed to determine the destination address associated with a first application on the first server. The data packet is transmitted based on the address associated with the first application. In some aspects, transmitting data packets includes a flow control mechanism to control data transmission.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: June 10, 2014
    Assignee: Alibaba Group Holding Limited
    Inventors: Jian Qiang Hu, Hao Dong, Li Huang, Dong Fang Ji, Guang Xue Li, Qing Ren, Feng Shi, Ke Tang, Yang Sheng Xiao, Ming Hua Zhao
  • GPR120 RECEPTOR AGONISTS AND USES THEREOF
    Publication number: 20140121246
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 1, 2014
    Applicant: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Christopher J. Rabbat, Jingyuan Ma, Aaron Novack, Imad Nashashibi, Xin Chen
  • Agonists of GPR131 and uses thereof
    Patent number: 8703776
    Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
    Type: Grant
    Filed: June 13, 2012
    Date of Patent: April 22, 2014
    Assignee: Cymabay Therapeutics, Inc.
    Inventors: Aaron Robert Novack, Dong-Fang Shi, Jingyuan Ma, Imad Nashashibi, Phuongly Pham, Jiangao Song, David W. G. Wone, Xueyan Wang, Jeffrey D. Johnson, Brian Edward Lavan, Charles A. McWherter, Xin Chen
  • CANCER TARGETS AND USES THEREOF
    Publication number: 20140099310
    Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
    Type: Application
    Filed: August 6, 2013
    Publication date: April 10, 2014
    Applicant: CELERA CORPORATION
    Inventors: Dong FANG, Paul MOORE, Steve RUBEN, Sudeepta AGGARWAL
  • HAND HELD DEVICE HAVING A METAL ROD FORMING A ROTATIONAL AXIS
    Publication number: 20140033551
    Abstract: A hand held device comprising: a handle, said handle comprising a grip portion and a connection portion, said connection portion rotating with respect to said grip portion about a rotational axis, said connection portion forming a docking portion suitable for receiving an optional head unit, said docking portion being positioned opposite distally away from said grip portion, wherein the grip portion and the connection portion are connected by a rod comprising a metal material, said rod comprising a distal end non-rotatably attached to the grip portion and a proximal end non-rotatably attached to the connection portion, wherein rotational axis forms a central longitudinal axis of said rod.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 6, 2014
    Applicant: The Gillette Company
    Inventors: Andrew Anthony Szczepanowski, Florina Winter, Dong Fang
  • GPR120 receptor agonists and uses thereof
    Patent number: 8598374
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: October 5, 2012
    Date of Patent: December 3, 2013
    Assignee: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Christopher J. Rabbat, Jingyuan Ma, Aaron Novack, Imad Fayek Nashashibi, Xin Chen, Phuongly Pham
  • Cancer targets and uses thereof
    Patent number: 8524238
    Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: September 3, 2013
    Assignee: Celera Corporation
    Inventors: Dong Fang, Paul Moore, Steve Ruben, Sudeepta Aggarwal
  • Communication Method and Server of Transmission Control Protocol
    Publication number: 20130195108
    Abstract: This disclosure provides methods and servers to transmit data packets via Transmission Control Protocol (TCP) connections. In some aspects, transmitting data packets includes receiving a data packet from a first application on a first server. The data packet is analyzed to determine a destination address associated with a second server. The data packet is transmitted based on the address associated with the second server. In some aspects, transmitting data packets includes receiving a data packet from a second application on a second server. The data packet is analyzed to determine the destination address associated with a first application on the first server. The data packet is transmitted based on the address associated with the first application. In some aspects, transmitting data packets includes a flow control mechanism to control data transmission.
    Type: Application
    Filed: October 14, 2011
    Publication date: August 1, 2013
    Applicant: ALIBABA GROUP HOLDING LIMITED
    Inventors: Jian Qiang Hu, Hao Dong, Li Huang, Dong Fang Ji, Guang Xue Li, Qing Ren, Feng Shi, Ke Tang, Yang Sheng Xiao, Ming Hua Zhao
  • GPR120 receptor agonists and uses thereof
    Patent number: 8476308
    Abstract: GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: July 2, 2013
    Assignee: Metabolex, Inc.
    Inventors: Dong Fang Shi, Jiangao Song, Jingyuan Ma, Aaron Novack, Phuongly Pham, Imad Fayek Nashashibi, Christopher J. Rabbat, Xin Chen
  • Method of utilizing the pts gene and anti-sense ads to increase patchouli alcohol content in L
    Patent number: 8476492
    Abstract: The invention relates to a method of utilizing the pts gene and antisense ads to increase patchouli alcohol content in Artemisia annua L. plants. Using transgenic Artemisia annua L. plants, the method of the invention consistently increases the patchouli alcohol content in those plants, thus laying down a solid foundation for large-scale production of patchouli alcohol and other secondary metabolites such as terpenes other than artemisinin.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: July 2, 2013
    Assignee: Firmenich Aromatics (China) Co., Ltd.
    Inventors: Ke Xuan Tang, Yue Yue Wang, Yue Li Tang, Dong-Fang Chen
  • Method of utilizing the PTS gene and RNA interference of the ads gene to increase patchouli alcohol content in L.
    Patent number: 8476491
    Abstract: The invention relates to a method of utilizing the pts gene and RNA interference of the ads gene to increase patchouli alcohol content in Artemisia annua L. plants. Using transgenic Artemisia annua L. plants, the method of the invention consistently increases the patchouli alcohol content in those plants, thus laying down a solid foundation for large-scale production of patchouli alcohol and other secondary metabolites such as terpenes other than artemisinin.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: July 2, 2013
    Assignee: Firmenich Aromatics (China) Co., Ltd.
    Inventors: Ke Xuan Tang, Yue Yue Wang, Yue Li Tang, Dong-Fang Chen
  • BISAMINOETHANETHIOL-TARGETING LIGAND CONJUGATES AND COMPOSITIONS
    Publication number: 20130165631
    Abstract: The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.
    Type: Application
    Filed: July 18, 2012
    Publication date: June 27, 2013
    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: David J. Yang, Chun W. Liu, Dong-Fang Yu, E. Edmund Kim
  • CIRCUIT BOARD STRUCTURE AND METHOD FOR MANUFACTURING THE SAME
    Publication number: 20130140062
    Abstract: A manufacturing method of a circuit board structure includes steps of: providing a circuit board which comprising a metal substrate, a metal layer and a dielectric layer disposed between the metal substrate and the metal layer; forming grooves on the circuit board to expose the metal substrate, the dielectric layer and the metal layer; performing a procedure for connecting metal in the grooves so that the metal substrate and the metal layer being in contact with each other. A structure of circuit board comprises a metal substrate, a dielectric layer and a metal layer. The dielectric layer is formed on the metal substrate, and the metal layer is formed on the dielectric layer; wherein the metal substrate and the metal layer can be in contact with each other at an appropriate position by performing a metal connecting procedure.
    Type: Application
    Filed: January 4, 2012
    Publication date: June 6, 2013
    Inventors: Kuang-Yao Chang, Lin-Dong Fang
  • Image-guided therapy of myocardial disease: composition, manufacturing and applications
    Patent number: 8440168
    Abstract: Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moeity comprising a beta-adrenergic receptor targeting compound conjugated or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: May 14, 2013
    Assignee: The Board of Regents of the University of Texas System
    Inventors: David J. Yang, Chang-Sok Oh, Saady Kohanim, Dong-Fang Yu, Richard Mendez, E. Edmund Kim
  • CANCER TARGETS AND USES THEREOF
    Publication number: 20130078253
    Abstract: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (“CAT”). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
    Type: Application
    Filed: March 30, 2012
    Publication date: March 28, 2013
    Applicant: CELERA CORPORATION
    Inventors: Dong FANG, Paul MOORE, Steve RUBEN, Sudeepta AGGARWAL
  • AGONISTS OF GPR131 AND USES THEREOF
    Publication number: 20130059856
    Abstract: Chemical compounds which act as agonists of, or otherwise modulate the activity of, GPR131 are disclosed. Related compositions, formulations and methods of use are also described.
    Type: Application
    Filed: June 13, 2012
    Publication date: March 7, 2013
    Inventors: Aaron Robert Novack, Dong-Fang Shi, Jingyuan Ma, Imad Nashashibi, Phuongly Pham, Jiangao Song, David W. G. Wone, Xueyan Wang, Jeffrey D. Johnson, Brian Edward Lavan, Charles A. McWherter, Xin Chen
  • BICYCLIC AGONISTS OF GPR131 AND USES THEREOF
    Publication number: 20130059845
    Abstract: The present disclosure relates to compounds that act as agonists of, or otherwise modulate the activity of, GPR131 and to their use in the treatment of various diseases. In particular embodiments, the structure of the compounds is given by Formula I: wherein the variables are as described herein. Related compositions, formulations and methods for the preparation of compounds of formula I are also described.
    Type: Application
    Filed: August 24, 2012
    Publication date: March 7, 2013
    Inventors: Jiangao SONG, Phuongly Pham, Jingyuan Ma, Aaron Robert Novack, Imad Nashashibi, David W. G. Wone, Dong-Fang Shi, Xin Chen
  • N-LINKED HETEROCYCLIC RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETES AND METABOLIC DISORDERS
    Publication number: 20120322804
    Abstract: Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
    Type: Application
    Filed: May 3, 2012
    Publication date: December 20, 2012
    Inventors: Jingyuan Ma, Christopher J. Rabbat, Jiangao Song, Xin Chen, Imad Nashashibi, Zuchun Zhao, Aaron Novack, Dong Fang Shi, Peng Cheng, Yan Zhu, Alison Murphy