Abstract: Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: The present invention relates to apparatus (10) for determining a contribution of at least one grid subsystem of plural grid subsystems to oscillation in angle or grid oscillation in an electrical grid (12). The apparatus (10) is configured to receive a first quantity which corresponds to oscillation in angle at a first grid subsystem (14). The apparatus (10) is also configured to receive a second quantity which corresponds to oscillation in angle at a second grid subsystem (16). The apparatus (10) comprises a processor (32) which is operative to determine a contribution of at least one of the first and second grid subsystems to oscillation in angle or grid oscillation with the contribution being determined in dependence on a phase relationship between the first and second quantities.

Abstract: A method of controlling an electrical power network in which a sudden event which may lead to loss or excess of generation or load. The electrical power network comprises plural controllers, each controller configured to control an apparatus connected to the power network at a different respective location in the electrical power network. The method comprises determining the occurrence of the sudden and receiving synchronised quantities in each of the controllers each of the quantities corresponding to one of frequency and angle at respective different locations in the electrical power network. The method further comprises generating a control output from each controllers in dependence on the received plural quantities, each control output controlling its respective apparatus, each controller generating the control output independent of operation of any other controller and on an ongoing basis in dependence on ongoing receipt of the plural quantities.

Abstract: The present invention relates to a method of monitoring oscillations that are liable to interact in an electrical power network, in dependence on measurement of AC waveforms in the electrical power network. The method comprises receiving first waveform data corresponding to an electrical quantity in each phase of at least two phases of three-phase AC waveforms at a location in the electrical power network. The method further comprises applying a transformation to the first waveform data to provide therefrom second waveform data corresponding to an electrical quantity at the location in a single phase representation, the second waveform data depending on the at least two phases.

Abstract: The disclosed systems and methods relate to profiling users and recommending tires, and, more particularly, for systems and methods for determining the most appropriate tires for a customer based on fitment, location, and the customer's personal preferences. In some example embodiments, system may according to the present disclosure determine the most appropriate tires for a customer based on the customer's personal preferences, fitment, and location. In some embodiments, the system may provide a quiz (or “persona selection”) to the customer and, based on the findings provided by the quiz, return a data set tailored to the driving style and product preferences of the customer (or user). The data set may then be used to determine the most appropriate tire for the customer.

Abstract: A non-pneumatic tire is provided that has a hub with a central axis. A supporting structure is located outward from the hub in a radial direction, and a shear band is located outward from the supporting structure in the radial direction. Tread is located outward from the shear band in the radial direction. A static discharge element extends from a first radial end of the supporting structure to a second radial end of the supporting structure. The first radial end is located closer to the central axis than the second radial end in the radial direction. The static discharge element is electrically conductive to conduct electricity through the supporting structure.

Abstract: Business transactions are complex and require numerous documents to be completed. Moreover, managing signatures to every one of the documents in such transactions is also an important aspect. Traditional systems and method are not adept at handling the intricacies of complex business transactions. The disclosure herein relates to an improved system and method for managing virtual signatures and electronic documents, wherein documents are managed via an online web infrastructure, the documents are drafted, distributed, collected and verified using virtual signatures at the web infrastructure.

Abstract: A motor vehicle includes mating features in a sheet metal of the motor vehicle, an exterior rear view mirror assembly fixedly secured to the motor vehicle, where the exterior rear view mirror assembly includes a structural base frame that mates to the mating features of the sheet metal at a mounting plane, and a tuned mass damper secured to the structural base frame adjacent to the mounting plane. In an example, a primary axis of movement of the tuned mass damper is at least one of substantially parallel with or substantially perpendicular to the mounting plane. In another example, the tuned mass damper is configured to dampen resonant vibrations being generated by the motor vehicle.

Abstract: Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.

Abstract: Compounds and compositions useful for treating disorders related to Kit are described herein.

Abstract: An exterior rear-view assembly for a vehicle has at least one reflective element and at least one camera fixedly secured to a backing plate and movable therewith. A heating device having at least one heatable element is between the backing plate and the reflective element. The heatable element is divided into first and second regions, wherein the first and second regions are subjected to different heating output over time. At least one information element and at least one window for electromagnetic radiation are disposed in the second region and are visible before the entire reflective element is defrosted.

Abstract: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.

Abstract: An embodiment may involve a wireless remote control unit that comprises a wireless communication interface, an input device, a display, a processing unit, and data storage comprising instructions executable by the processing unit to carry out various operations. The operations include (i) establishing communication with an electronic gaming machine using the wireless communication interface, (ii) displaying on the display at least one game-play option for a particular wager game on the electronic gaming machine, (iii) receiving via the input device data indicative of a game-play command for the particular wager game, and (iv) sending to the electronic gaming machine, via the wireless communication interface, instructions for carrying out the game-play command.

Abstract: Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.

Abstract: Described herein are compounds that inhibit wild-type RET and its resistant mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: A molded article with an axis of rotation about a central axis having an outer interface element, an inner interface element, and a plurality of web spokes positioned therebetween. The common surfaces of the inner and outer interface elements and a pair of adjacent web spokes form a void space. The radially inner surface of an interface element common to one of the voids has a maximum radius of curvature in the longitudinal direction at any given point less than the distance between that point and the axis of rotation.

Abstract: Indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compounds.

Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: Compounds and compositions useful for treating disorders related to mutant KIT are described herein.