Patents by Inventor Douglas L. Cole

Douglas L. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neckwear and jewelry storage device
    Patent number: 8672146
    Abstract: A vertically adjustable combination neckwear and jewelry storage device comprised of a head rail assembly, a jewelry rail assembly, and a plurality of neckwear rods operatively connected together such that jewelry rail assembly and the plurality of neckwear rods vertically adjust with respect to the head rail assembly.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: March 18, 2014
    Inventor: Douglas L. Cole
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7723511
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: May 25, 2010
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar, Zacharia S. Cheruvallath
  • Analytical Methods for Validating Excipient Purity
    Publication number: 20090124709
    Abstract: The invention concerns methods of validating the purity of n-Dodecyl beta-D-maltoside (DDM), a membrane permeation enhancer used in nasal and oral drug delivery methods, using HPLC and Mass Spectrometry techniques.
    Type: Application
    Filed: September 9, 2008
    Publication date: May 14, 2009
    Inventors: Douglas L. Cole, Jing J. Zhang
  • SYNTHESIS OF SULFURIZED OLIGONUCLEOTIDES
    Publication number: 20080293929
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Application
    Filed: April 21, 2008
    Publication date: November 27, 2008
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7378516
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: May 27, 2008
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Derivatization and low level detection of drugs in biological fluid and other solution matrices using a proxy marker
    Publication number: 20080111066
    Abstract: New and improved mass spectrometry methods of determining the pharmacokinetic fate of a compound of interest are described. The methods involve PEGylating the compound, administering to a biological system, withdrawing an analyte from said system, and subjecting said analyte to in-source ionization and fragmentation into PEG ions that are then measured as a surrogate marker or markers for the presence and/or amount of said compound in said analyte.
    Type: Application
    Filed: August 31, 2006
    Publication date: May 15, 2008
    Inventors: Jing Jim Zhang, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 7227016
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: June 5, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Synthesis of sulfurized oligonucleotides
    Patent number: 7227015
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Grant
    Filed: January 10, 2001
    Date of Patent: June 5, 2007
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga T. Ravikumar, Zacharia S. Cheruvallath
  • Process for the synthesis of oligomeric compounds
    Patent number: 7199236
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: April 3, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7186822
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: March 6, 2007
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei P. Guzaev
  • Process for the synthesis of oligomeric compounds
    Patent number: 7041816
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: May 9, 2006
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Window component extrusion
    Patent number: D508740
    Type: Grant
    Filed: May 6, 2004
    Date of Patent: August 23, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D509913
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: September 20, 2005
    Assignee: Mikron Industries, Inc
    Inventor: Douglas L. Cole
  • Window component extrusion 8575
    Patent number: D517222
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: March 14, 2006
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D521655
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 23, 2006
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D536103
    Type: Grant
    Filed: May 3, 2005
    Date of Patent: January 30, 2007
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D536104
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: January 30, 2007
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D537960
    Type: Grant
    Filed: October 19, 2005
    Date of Patent: March 6, 2007
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D558899
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: January 1, 2008
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D577131
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: September 16, 2008
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole