Patents by Inventor Douglas L. Cole

Douglas L. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the synthesis of oligomers using phosphoramidite compositions
    Patent number: 6610842
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: May 6, 1999
    Date of Patent: August 26, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030149260
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 7, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Method of synthesizing phosphorothioate oligonucleotides
    Publication number: 20030114662
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Application
    Filed: January 17, 2003
    Publication date: June 19, 2003
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Process for the synthesis of oligomeric compounds
    Publication number: 20030088088
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 8, 2003
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Synthesis of oligonucleotides
    Publication number: 20030069412
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes.
    Type: Application
    Filed: October 11, 2002
    Publication date: April 10, 2003
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6521775
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: February 18, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Method for the synthesis of nucleotide of oligonucleotide phosphoramidites
    Publication number: 20030013864
    Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Application
    Filed: August 29, 2002
    Publication date: January 16, 2003
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Patent number: 6486312
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: November 26, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6465628
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: April 9, 1999
    Date of Patent: October 15, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Compounds for the synthesis of nucleotide or oligonucleotide phosphoramidites
    Patent number: 6458941
    Abstract: This invention presents novel methods for recovery of phophoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: October 1, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Method of synthesizing phosphorothioate oligonucleotides
    Publication number: 20020128466
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Application
    Filed: February 6, 2002
    Publication date: September 12, 2002
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Compounds for the Synthesis of Nucleotide or oligonucleotide phosphoramidites
    Patent number: 6441150
    Abstract: This invention presents novel methods for recovery of phosphoramidites from the waste products of oligonucleotide synthesis. The methods include reacting a tribromophenoxydichlorophosphorane with an H-phosphonate in the presence of an amine.
    Type: Grant
    Filed: August 23, 1999
    Date of Patent: August 27, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Richard H. Griffey, Douglas L. Cole, Vasulinga Ravikumar
  • Trans cyclopentanyl purine analogs useful as immunosuppressants
    Patent number: 6436947
    Abstract: This invention relates to Trans cyclopentanyl purine analogs of the formula (1) wherein the substituent in the 3-position on the cyclopentanyl ring is in the Trans configuration relative to the bicyclic substituent, Y3, Y5 Y7, Y9 are each nitrogen and Y8 is a CH group, R is a hydrogen, a C1-C7 alkyl acyl or aryl acyl, Q is NH2, halogen or hydrogen, Z is hydrogen, halogen, or NH2; or a pharmaceutically-acceptable salt thereof, and to their use as immunosuppressants.
    Type: Grant
    Filed: November 20, 1997
    Date of Patent: August 20, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
  • Method of synthesizing phosphorothioate oligonucleotides
    Patent number: 6403781
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Grant
    Filed: January 8, 2001
    Date of Patent: June 11, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Reagent useful for synthesizing sulfurized oligonucleotide analogs
    Patent number: 6399831
    Abstract: The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole, Daniel C. Capaldi
  • Process for the synthesis of oligomeric compounds
    Patent number: 6399756
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: June 4, 2002
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Window component extrusion
    Patent number: D459490
    Type: Grant
    Filed: April 4, 2001
    Date of Patent: June 25, 2002
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D468454
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: January 7, 2003
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D470251
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: February 11, 2003
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D472982
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: April 8, 2003
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole