Patents by Inventor Douglas L. Cole

Douglas L. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of oligonucleotides
    Patent number: 6870039
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: September 19, 2003
    Date of Patent: March 22, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Oligomer phosphoramidite compositions and processes for synthesizing the same
    Patent number: 6858722
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: February 22, 2005
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the synthesis of oligomeric compounds
    Patent number: 6858715
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: February 22, 2005
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Process for the synthesis of oligomeric compounds
    Publication number: 20040219577
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
    Type: Application
    Filed: January 20, 2004
    Publication date: November 4, 2004
    Inventors: Vasulinga T. Ravikumar, Muthiah Manoharan, Daniel C. Capaldi, Achim Krotz, Douglas L. Cole, Andrei Guzaev
  • Diribonucleoside Phosphoramidites
    Patent number: 6780989
    Abstract: This invention presents novel methods for synthesizing phosphorothioate oligonucleotides, using support-bound phosphoramidites. Novel intermediates useful in the methods are also provided.
    Type: Grant
    Filed: January 17, 2003
    Date of Patent: August 24, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Douglas L. Cole, Vasulinga Ravikumar
  • Synthesis of oligonucleotides
    Publication number: 20040063925
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes.
    Type: Application
    Filed: September 19, 2003
    Publication date: April 1, 2004
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Intermediates for the synthesis of oligonucleotide analogues
    Patent number: 6677471
    Abstract: Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. Also provided are synthetic intermediates useful in such processes.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: January 13, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Zacharia S. Cheruvallath, Vasulinga T. Ravikumar, Douglas L. Cole
  • Oligomer phosphoramidite compositions and processes for synthesizing the same
    Publication number: 20030229220
    Abstract: Synthetic processes are provided wherein oligomers are prepared using phosphoramidite compositions. Oligomers having phosphodiester, phosphorothioate, phosphorodithioate covalent linkages are prepared that can include other covalent linkages. Also provided are compositions useful in such processes.
    Type: Application
    Filed: May 23, 2003
    Publication date: December 11, 2003
    Inventors: Vasulinga T. Ravikumar, Daniel C. Capaldi, Douglas L. Cole
  • Process for the preparation of oligonucleotide compounds
    Patent number: 6649750
    Abstract: Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: November 18, 2003
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Daniel C. Capaldi, Vasulinga T. Ravikumar, Douglas L. Cole
  • Synthesis of sulfurized oligonucleotides
    Publication number: 20030212267
    Abstract: Methods for the formation of sulfurized oligonucleotides are provided. The methods allow for the formation of phosphorothioate linkages in the oligonucleotides or derivatives, without the need for complex solvent mixtures and repeated washing or solvent changes. Oligonucleotides having from about 8, and up to about 50, nucleotides can be sulfurized according to the methods of the invention with higher yields than have been previously reported.
    Type: Application
    Filed: December 12, 2002
    Publication date: November 13, 2003
    Inventors: Douglas L Cole, Vasulinga T Ravikumar, Zacharia S Cheruvallath
  • Synthesis of oligonucleotides
    Patent number: 6646114
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: November 11, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Window component extrusion
    Patent number: D504958
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 10, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D504959
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: May 10, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D505498
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 24, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D505499
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 24, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D505500
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 24, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D505501
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 24, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D505502
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: May 24, 2005
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D493237
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: July 20, 2004
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D493544
    Type: Grant
    Filed: August 27, 2003
    Date of Patent: July 27, 2004
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole