Patents by Inventor Douglas L. Cole

Douglas L. Cole has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbocyclic nucleoside analogs useful as immunosuppressants
    Patent number: 5605903
    Abstract: This invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering an effective amount of a compound of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentenyl ring is inthe CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: February 25, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
  • Synthesis of oligonucleotides
    Patent number: 5571902
    Abstract: Synthetic processes are provided for the solution phase synthesis of oligonucleotides, especially phosphorothioate oligonucleotides, and intermediate compounds useful in the processes. Intermediates having structure ##STR1## are prepared in accord with preferred embodiments.
    Type: Grant
    Filed: May 26, 1994
    Date of Patent: November 5, 1996
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Douglas L. Cole
  • Carbocation scavenging during oligonucleotide synthesis
    Patent number: 5510476
    Abstract: During the synthesis of oligonucleotides and phosphate linked oligomers, a carbocation scavenging agent is employed to increase the overall yield. The carbocation scavenging agent is used in conjunction with an acidic solution employed during the deprotection step.
    Type: Grant
    Filed: July 7, 1994
    Date of Patent: April 23, 1996
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Vasulinga Ravikumar, Mark Andrade, Dennis Mulvey, Douglas L. Cole
  • Carbocyclic nucleoside analogs useful as immunosuppressants
    Patent number: 5470857
    Abstract: This invention relates to a method of effecting immunosuppression in a patient in need thereof comprising administering an effective amount of a compound of the formula (1) ##STR1## wherein the hydroxy substituent on the cyclopentenyl ring is in the CIS configuration relative to the bicyclic substituent,Y.sub.3, Y.sub.7, Y.sub.8 and Y.sub.9 are each independently nitrogen or a CH group,Q is NH.sub.2, halogen or hydrogen, andZ is hydrogen, halogen, or NH.sub.2 ;or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: November 28, 1995
    Assignee: Marion Merrell Dow Inc.
    Inventors: David R. Borcherding, Carl K. Edwards, III, Ronald E. Esser, Douglas L. Cole
  • Window component extrusion
    Patent number: D351665
    Type: Grant
    Filed: April 22, 1993
    Date of Patent: October 18, 1994
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D353210
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: December 6, 1994
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D353470
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: December 13, 1994
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D353471
    Type: Grant
    Filed: August 30, 1993
    Date of Patent: December 13, 1994
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D353897
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: December 27, 1994
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D356381
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: March 14, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D356646
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: March 21, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D357074
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: April 4, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D357545
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: April 18, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D358663
    Type: Grant
    Filed: July 9, 1993
    Date of Patent: May 23, 1995
    Assignee: Mikron Industries
    Inventors: Sam S. Hosseini, Douglas L. Cole
  • Window component extrusion
    Patent number: D360040
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: July 4, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D360041
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: July 4, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D361140
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: August 8, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D363355
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: October 17, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D365644
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: December 26, 1995
    Assignee: Mikron Industries
    Inventor: Douglas L. Cole
  • Window component extrusion
    Patent number: D376433
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: December 10, 1996
    Assignee: Mikron Industries, Inc.
    Inventor: Douglas L. Cole