Patents by Inventor Douglas Phillips

Douglas Phillips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Calcium channel blocking polypeptide from agelenopsis aperta and therapeutic methods employing it
    Patent number: 5599559
    Abstract: A polypeptide isolated from the venom of the Agelenopsis aperta spider blocks calcium channels in cells of various organisms and is useful in blocking such calcium channels in cells per se, in the treatment of calcium channel-mediated diseases and conditions, and in the control of invertebrate pests.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: February 4, 1997
    Assignee: Pfizer Inc.
    Inventors: Douglas Phillips, Mary E. Kelly, Nicholas A. Saccomano, Robert A. Volkmann
  • Intermediate for the preparation of penems
    Patent number: 5286857
    Abstract: An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1-yl]acetic acid esters.
    Type: Grant
    Filed: October 9, 1990
    Date of Patent: February 15, 1994
    Assignee: Pfizer Inc.
    Inventors: Brian T. O'Neill, Douglas Phillips
  • Process for the preparation of penems
    Patent number: 5191075
    Abstract: An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1-yl]acetic acid esters.
    Type: Grant
    Filed: March 17, 1992
    Date of Patent: March 2, 1993
    Assignee: Pfizer Inc
    Inventors: Brian T. O'Neill, Douglas Phillips
  • Polypeptides useful as blockers of calcium channels
    Patent number: 5122596
    Abstract: This invention relates to a polypeptide found to be present in the venom of the Agelenopsis aperta spider and to polypeptides having substantially the same amino acid sequence and substantially the same activity as said polypeptide. The polypeptides of this invention and the salts thereof block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se; in the treatment of calcium channel mediated diseases and conditions; and in the control of invertebrate pests. This invention also relates to compositions comprising said polypeptides and salts thereof.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: June 16, 1992
    Assignee: Pfizer Inc.
    Inventors: Douglas Phillips, Nicholas A. Saccomano, Robert A. Volkmann
  • Penem derivatives
    Patent number: 4992543
    Abstract: An efficient, multistep process for the synthesis of certain 6-(1-hydroxyethyl) 2-substituted penem antibiotics from 2-[4R-(triphenylmethylthio)-3S-(1R-(dimethyl-t-butylsilyloxy)ethyl)-2-azet idon-1 yl]acetic acid ester.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: February 12, 1991
    Assignee: Pfizer Inc.
    Inventors: Brian T. O'Neill, Douglas Phillips
  • Process for the preparation of penems
    Patent number: 4895940
    Abstract: An efficient, multistep process for the synthesis of 6-(1-hydroxyethyl) 2-thio-substituted penem antibiotics from 2-[4R-(triphenylmethy lthio)-3S-(1S-(dimethyl-t-butylsilyloxy)ethyl)-2-azetidon-1-yl]acetic acid esters.
    Type: Grant
    Filed: October 19, 1988
    Date of Patent: January 23, 1990
    Assignee: Pfizer Inc.
    Inventors: Brian T. O'Neill, Douglas Phillips