Abstract: Disclosed is a method for preparing T cells for adoptive T cell therapy by contacting a population of activated T cells with an Eukaryotic initiation factor-4A (eIF4A) inhibitor. Also disclosed is a kit, a population of T cells or engineered T cells produced by the method and use of the same in adoptive T cell therapy and the treatment of cancer.

Abstract: Compositions and methods are provided for suppressing tumors by modulating the LAP pathway. Targeting components of the LAP pathway for specific drug design can be used as n immunotherapy strategy that modulates the tumor microenvironment. It is well established that infiltrating monocytes and macrophages play a pivotal role in shaping an immunosuppressive tumor microenvironment. By modulating LAP in the innate immune cells, the function of effector T cells can be manipulated toward an effective, cytotoxic immune response that can eliminate tumor cells. Thus, methods are provided for reducing the size or number of tumor cells and for treating cancer or other cell proliferative disorders. Further provided are methods for increasing the Th1 response or increasing IFN? and/or TNF? expression in the tumor microenvironment by administering a LAP inhibitor.

Abstract: Compositions and methods are provided for modifying and treating neuroinflammatory and neurodegenerative diseases. The methods and compositions can be used to ameliorate the effects of a deficiency in the LC3-associated endocytosis (LANDO) pathway for clearing ?-amyloid. Thus, methods are further provided for modulating ?-amyloid clearance using an effective amount of a pharmaceutical composition that targets the LANDO pathway. Accordingly, pharmaceutical compositions that target the LANDO pathway are provided herein. The methods and compositions described herein can be used to treat neuroinflammatory and neurodegenerative diseases, such as Alzheimer's disease.

Abstract: Compositions and methods are provided for suppressing tumors by modulating the LAP pathway. Targeting components of the LAP pathway for specific drug design can be used as n immunotherapy strategy that modulates the tumor microenvironment. It is well established that infiltrating monocytes and macrophages play a pivotal role in shaping an immunosuppressive tumor microenvironment. By modulating LAP in the innate immune cells, the function of effector T cells can be manipulated toward an effective, cytotoxic immune response that can eliminate tumor cells. Thus, methods are provided for reducing the size or number of tumor cells and for treating cancer or other cell proliferative disorders. Further provided are methods for increasing the Th1 response or increasing IFN? and/or TNF? expression in the tumor microenvironment by administering a LAP inhibitor.

Abstract: Compositions and methods are provided for blocking Tim4 on the surface of myeloid cells in order to treat and prevent cancer in a subject. Blocking Tim4 on the surface of myeloid cells can restore anti-tumor immunity and reduce the uptake of apoptotic cells. Further, by administering an anti-Tim4 antibody, the pro-inflammatory anti-tumor response can be increased. Accordingly, methods for reducing the uptake of apoptotic cells and methods for increasing anti-tumor immunity are provided herein. The present disclosure further describes a method for producing monoclonal antibodies that bind Tim4 on the surface of myeloid cells. The anti-Tim4 antibodies can further be selected for their ability to inhibit engulfment of dead or dying cells, to elicit the production of inflammatory cytokines, and to restrict the growth of tumors.

Abstract: Compositions and methods are provided for modifying diagnosing and treating inflammatory disease. The methods and compositions can be used to ameliorate the effects of a deficiency in the LAP pathway for clearing dead cells. Thus, methods are further provided for modulating dead cell clearance using an effective amount of a pharmaceutical composition that targets the LAP pathway. Accordingly, pharmaceutical compositions that target the LAP pathway re provided herein. The methods and compositions described herein can be used to treat inflammatory disease, such as systemic lupus erythematosus (SLE).

Abstract: A method and system for providing a user of a wireless communication device (WCD) with vending service. The WCD may present the user with data indicating items available for purchase from a vendor. The WCD may then receive the user's directive to order an item from the vendor. In response, the WCD may obtain data stored at a transponder in proximity to the WCD that indicates a location of the WCD. In one example, the transponder may be at a fixed location, such as by being affixed to a fixed object at a venue (e.g., a stadium seat), in which case the stored data may indicate the fixed location. The WCD may then send an order for the item and the obtained data to the vendor. In turn, the vendor may use the data to determine a location of the WCD and then deliver the item to the determined location.

Abstract: A location validation system comprising a communication interface configured to receive an asserted location of a wireless communication device and a processing system configured to determine a trusted location of the wireless communication device, receive the asserted location from the communication interface, compare the asserted location to the trusted location, and generate a notification if the asserted location differs from the trusted location.

Abstract: A wireless communication system generates operating information indicating if a monitoring wireless communication device is in active mode or in idle mode for a wireless data service. The wireless system receives location information that indicates geographic locations of a monitored wireless communication device for delivery to the monitoring wireless communication device. The system stores the location information if the monitoring wireless communication device is in idle mode. The system wirelessly transfers the location information to the monitoring wireless communication device if the monitoring wireless communication device is in active mode. If the monitoring wireless communication device transitions from idle mode to active mode and has stored location information, the system generates summary location data for the monitored wireless communication device based on the stored location information and wirelessly transfers the summary location data to the monitoring wireless communication device.

Abstract: Media and systems are provided for limiting bandwidth consumption in a network environment by presenting customized browser-presentable resources. A request for a base universal resource locator (URL), followed by a request for a specific resource, is received. An optimized URL for the request is generated. When a predetermined number of requests for the specific component resource are received during the course of accessing the base URL, subsequent user requests for the base URL are redirected to the optimized URL. Thus, only the specific resources are presented for display. Requests to return to the base URL can result in discontinuing redirection. Returning to the base URL and accessing additional resources can modify the enhanced URL or redirect requests for the base URL to a difference component resource. Network bandwidth usage is enhanced by recognizing repetitive user requests.

Abstract: A wireless communication system generates operating information indicating if a monitoring wireless communication device is in active mode or in idle mode for a wireless data service. The wireless system receives location information that indicates geographic locations of a monitored wireless communication device for delivery to the monitoring wireless communication device. The system stores the location information if the monitoring wireless communication device is in idle mode. The system wirelessly transfers the location information to the monitoring wireless communication device if the monitoring wireless communication device is in active mode. If the monitoring wireless communication device transitions from idle mode to active mode and has stored location information, the system generates summary location data for the monitored wireless communication device based on the stored location information and wirelessly transfers the summary location data to the monitoring wireless communication device.

Abstract: What is disclosed is a method for communicating a presence message from a presence server to a monitoring wireless communication device, wherein the presence message indicates a location-oriented status of a monitored wireless communication device. The method includes receiving the presence message from the presence server and determining if the monitoring wireless communication device is in an active mode. If the monitoring wireless communication device is in the active mode, the method includes transferring the presence message for delivery to the monitoring wireless communication device. If the monitoring wireless communication device is not in the active mode, the method includes applying filtering characteristics to the presence message, creating summary data of the presence message, and transferring the summary data of the presence message for delivery to the monitoring wireless communication device once the monitoring wireless communication device enters the active mode.

Abstract: A plurality of public safety answering points (PSAPs) are accessible via a voice-over-packet (VoP) network. A wireless access point of the VoP network is provisioned with a PSAP identifier and/or access point identifier to facilitate the routing of emergency services calls from the wireless access point to the appropriate PSAP. When a mobile node transmits a message to originate a call, the wireless access point parses the message to determine whether the mobile node is requesting an emergency services call. If an emergency call is being requested, the wireless access point inserts the PSAP identifier and/or access point identifier with which it has been provisioned into the message and forwards the modified message to a proxy server. The proxy server receives the modified message and routes the call to the appropriate PSAP, based on the PSAP identifier and/or access point identifier contained therein.

Abstract: Methods, media and systems are provided for generating a dynamic web portal in a wireless network, and the portal is based on personal usage. An initialized portal contains no web content. Systems include one or more network elements configured to monitor requests for resource components, to generate web portals, and to dynamically update the portals based on the requests for resource components. Data structures embodied on a computer-readable media are included for storing numerical data regarding the requests and for storing a plurality of portals. The dynamic web portal is updated to contain component resources from visited web pages, each having a respective universal resource locator (URL) or portion of code with which it is associated. Requests for resources are monitored and added to a web portal when a specified threshold is surpassed so that an updated web portal can be presented.

Abstract: Methods and systems are described for providing a presence service that is useful for mobile telecommunications devices. A plurality of outgoing presence updates are sent to a presence client. The system monitors the level of network traffic and determines whether the client is in a region of high network load, and if so, the system throttles the outgoing presence updates during the condition of high network load. The level of throttling may depend at least in part on the amount of time that has elapsed since the presence client began a presence session, and/or the amount of time that has elapsed since an incoming presence update was received from the presence client. In determining the latter amount of elapsed time, the system may consider only the amount of time elapsed since an incoming non-automatic presence update was received from the presence client.

Abstract: What is disclosed is a method of operating a wireless communication network to authenticate a geographic location of a wireless communication device. The method includes transferring an authentication key for delivery to a service node, obtaining the geographic location of the wireless communication device, and authenticating the geographic location to create authenticated location information for the wireless communication device. The method also includes wirelessly transferring the authenticated location information to the wireless communication device, wirelessly receiving the authenticated location information from the wireless communication device for delivery to the service node, and transferring the authenticated location information for delivery to the service node, wherein the service node processes authenticated location information and the authentication key to identify the geographic location of the wireless communication device.

Abstract: There is disclosed herein a method, system and computer software product for associating a location with a wireless modem, wherein the modem has a modem identifier and a registered address associated therewith and wherein the method comprises: receiving a communication transmitted by the modem wherein the communication includes the modem identifier; determining whether the base station first receiving the communication is located within a predetermined proximity of the registered address; associating with the communication a receiving base station identifier of the base station that first received the communication; associating with the registered address a registered address base station identifier associated therewith; and comparing the registered address base station identifier with the receiving base station identifier.

Abstract: Methods and systems are described for providing a presence service that is useful for mobile telecommunications devices. A plurality of outgoing presence updates are sent to a presence client. The system monitors the level of network traffic and determines whether the client is in a region of high network load, and if so, the system throttles the outgoing presence updates during the condition of high network load. The level of throttling may depend at least in part on the amount of time that has elapsed since the presence client began a presence session, and/or the amount of time that has elapsed since an incoming presence update was received from the presence client. In determining the latter amount of elapsed time, the system may consider only the amount of time elapsed since an incoming non-automatic presence update was received from the presence client.

Abstract: Methods, systems, and media are provided for interfacing components in a wireless telecommunications network. An interface allows for the efficient transfer of data that facilitates billing and operations functions. This data is transferred from proxy gateways to application servers to servers that provide billing functions and operations, administration, and management (OAM) functions. The interface enables the transmission by communicating a mobile switching center code, a proxy identifier, a traffic restriction flag, and a packet data unit type. By aggregating this information at the application server into a useful form for devices used in billing and operations, information technology (IT) overhead for billing and operations systems support is reduced. Also lowered is the congestion present on the network, as fewer links are necessary between servers and proxies.

Abstract: A method is provided for monitoring multicasting traffic in an internetwork between a multicasting source in a first domain and a multicasting destination in a second domain. The multicasting source offers connections to a predetermined multicast stream according to predetermined multicast group information. The multicasting destination sends a join message to a router within the internetwork in order to initiate routing of the predetermined multicast stream to the multicasting destination. A notification of the joining is sent from the router to a ledger application, the notification including identifying information of the multicasting destination and the multicasting source. The multicasting source transmitting datagrams of the predetermined multicast stream to the multicasting destination via the router. The ledger application receives and logs the notification as a transaction event.