Patents by Inventor Douglas R. Green

Douglas R. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhancement of adoptosis using antisense oligonucleotides
    Patent number: 5583034
    Abstract: A method is disclosed for enhancement of the efficacy of therapeutic treatment for inducing cell death in a cell having an anti-apoptotic gene by the enhancement of apoptosis. An antisense oligonucleotide is disclosed which hybridizes with the nucleic acid sequence of the anti-apoptotic gene. The oligonucleotide is administered to the cell in an amount sufficient to inhibit expression of the gene, thus rendering the cell susceptible to induction of apoptosis, and consequently achieving higher efficacy of therapeutic treatment.
    Type: Grant
    Filed: February 22, 1994
    Date of Patent: December 10, 1996
    Assignee: La Jolla Institute for Allergy and Immunology
    Inventors: Douglas R. Green, Thomas G. Cotter