Abstract: Methods and systems are described for providing a presence service that is particularly useful for mobile telecommunications devices. A plurality of outgoing presence updates are sent to a presence client. The system monitors the level of network traffic and determines whether the client is in a region of high network load. If the client is in a region experiencing a condition of high network load, the system throttles the outgoing presence updates during the condition of high network load. The level of throttling may depend at least in part on the amount of time that has elapsed since the presence client began a presence session, and/or the amount of time that has elapsed since an incoming presence update was received from the presence client. In determining the latter amount of elapsed time, the system may consider only the amount of time elapsed since an incoming non-automatic presence update was received from the presence client.

Abstract: Methods of modulating a T cell response are provided. Methods include, among other things, contacting a T cell that expresses TNF-related apoptosis-inducing ligand (TRAIL, Apo-2L) or TRAIL receptor (DR4 or DR5) with a molecule that binds to TRAIL (Apo-2L), a molecule that binds to TRAIL receptor (DR4 or DR5), or with a soluble TRAIL (Apo-2L) reagent.

Abstract: A method is provided in a communication system for determining a relative position change of a wireless modem. The first location of the wireless modem is determined, and then the wireless modem reports the first location to a service node. A dead reckoning device within the wireless modem then determines a second location of the wireless modem. If the second location is greater than a predetermined distance from the first location, then the wireless modem reports the second location to the service node.

Abstract: What is disclosed is a method for communicating a presence message from a presence server to a monitoring wireless communication device, wherein the presence message indicates a location-oriented status of a monitored wireless communication device. The method includes receiving the presence message from the presence server and determining if the monitoring wireless communication device is in an active mode. If the monitoring wireless communication device is in the active mode, the method includes transferring the presence message for delivery to the monitoring wireless communication device. If the monitoring wireless communication device is not in the active mode, the method includes applying filtering characteristics to the presence message, creating summary data of the presence message, and transferring the summary data of the presence message for delivery to the monitoring wireless communication device once the monitoring wireless communication device enters the active mode.

Abstract: What is disclosed is a method of operating a wireless communication network to authenticate a geographic location of a wireless communication device. The method includes transferring an authentication key for delivery to a service node, obtaining the geographic location of the wireless communication device, and authenticating the geographic location to create authenticated location information for the wireless communication device. The method also includes wirelessly transferring the authenticated location information to the wireless communication device, wirelessly receiving the authenticated location information from the wireless communication device for delivery to the service node, and transferring the authenticated location information for delivery to the service node, wherein the service node processes authenticated location information and the authentication key to identify the geographic location of the wireless communication device.

Abstract: Methods, media and systems are provided for generating a dynamic web portal in a wireless network, and the portal is based on personal usage. An initialized portal contains no web content. Systems include one or more network elements configured to monitor requests for resource components, to generate web portals, and to dynamically update the portals based on the requests for resource components. Data structures embodied on a computer-readable media are included for storing numerical data regarding the requests and for storing a plurality of portals. The dynamic web portal is updated to contain component resources from visited web pages, each having a respective universal resource locator (URL) or portion of code with which it is associated. Requests for resources are monitored and added to a web portal when a specified threshold is surpassed so that an updated web portal can be presented.

Abstract: A client device transmits, via a voice-over-packet (VoP) access network, a message that requests an emergency services call. An outbound proxy server receives the message and obtains a network-provided location of the client device, e.g., by looking up the source address of the message in a location database maintained by the access network or by invoking an active network location function. The outbound proxy server inserts the network-provided location into the message, leaving any client-provided location in the message undisturbed, and forwards the message to an emergency services routing server. The emergency services routing server determines which public safety answering point (PSAP) should receive the call, based on at least one of the network-provided location and any client-provided location in the message.

Abstract: A method for identifying therapeutically effective immunosuppressive agents by screening such agents for those which induce apoptosis in activated T cells is disclosed. T cells were isolated then activated and treating with various test compounds. A caspase substrate is added to detect caspase activation and apoptosis in the cells. Compounds which stimulate caspase activation and apoptosis are also tested against resting T cells to determine those agents which are more effective in activated T cells compared to resting T cells. Compounds with this selectivity are effective in treating immunopathological disorders such as arthritis, graft rejection, graft versus host disease, inflammatory bowel syndrome and the like.

Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.

Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: 1

Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.

Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

Abstract: The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: 1

Abstract: The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy and radiation therapy and for treating and ameliorating the side effects of chemotherapy and radiation therapy of cancer is disclosed.

Abstract: The present invention is directed to novel substituted &agr;-hydroxy acid thereof, represented by the general Formula I: where R1-R5, X and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

Abstract: A method for identifying therapeutically effective immunosuppressive agents by screening such agents for those which induce apoptosis in activated T cells is disclosed. T cells were isolated then activated and treating with various test compounds. A caspase substrate is added to detect caspase activation and apoptosis in the cells. Compounds which stimulate caspase activation and apoptosis are also tested against resting T cells to determine those agents which are more effective in activated T cells compared to resting T cells. Compounds with this selectivity are effective in treating immunopathological disorders such as arthritis, graft rejection, graft versus host disease, inflammatory bowel syndrome and the like.

Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: 1

Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.

Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.

Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.