Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: A detachable carrier assembly is provided. The detachable carrier assembly includes a bracket assembly configured for attachment to a head tube of a bicycle and a plurality of segments configured for insertion into the bracket assembly. The plurality of segments is further configured for detachment from the bracket assembly. A container is attached to the plurality of segments. The container is configured to hold a quantity of desired articles.

Abstract: Systems, apparatus, and methods for capturing data related to athletic performances. Some methods comprise displaying a site map for the performance and accepting a selection of a target for the performance. Various methods comprise estimating, based on the user location, the initial location of the object and recording data regarding the performance. Moreover, some methods also comprise using a satellite-based map as the site map. If desired, the estimating comprises sensing a pause in the changing user location. Some methods further comprise estimating a trajectory of the object using the initial location of the object and a portion of the trajectory. In some scenarios, methods comprise capturing a location of the object at the ending of the performance. The recording can further comprise capturing a video of the performance. Furthermore, these methods can comprise capturing subjective information regarding the performance.

Abstract: A seal assembly includes a cover. A panel sealing apparatus includes the seal assembly. The apparatus includes a wall defining an orifice and the cover is disposed through the orifice. The cover includes a collar and a flange extending outwardly away from the collar. The cover defines an aperture through the collar and the flange. The assembly also includes a plate overlapping the flange and defining a hole. The collar of the cover is disposed through the hole. The assembly further includes a seal defining a passageway. The cover is disposed through the passageway. The assembly also includes a bushing defining an opening. The collar of the cover is disposed through the opening such that the bushing surrounds the collar. At least one of the plate and the bushing is configured to allow movement of the cover independently of the seal.

Abstract: Inhibiting formation of optical artifacts in a multi-layer film polarizer of an optical imaging assembly that includes a polarizing beam splitter. The beam splitter may include a multilayer reflective polarizing film having at least two materials, one of which may exhibit birefringence after uniaxial orientation; an adhesive disposed on the multilayer reflective polarizing film; and at least a first prism disposed on the adhesive. The adhesive may include a plasticizer for inhibiting formation of optical artifacts in the polarizing film.

Abstract: A system and method to modify avatar characteristics and, in particular, to modify avatar characteristics based on inferred conditions. The system comprises a collection engine configured to collect one or more inputs and at least one rule set. The system also comprises an emotion engine configured to accept the one or more inputs and operate on the at least one rule set by comparing the one or more inputs to the at least one rule set, the emotion engine configured to modify at least one characteristic of a user participating in a virtual universe when the comparing produces a match.

Abstract: Under the present disclosure, a chat interface and computer program product for comparing free time between instant message chat members in order to schedule an upcoming event are provided. One approach includes: storing individual calendars corresponding to each member of the chat; initiating a free time comparison; and combining the individual calendars corresponding to each member of the chat into a free time summary calendar, wherein the free time summary calendar indicates at least one of free time periods that are simultaneously available to all of the members of the chat and conflict time periods during which at least two chat members simultaneously have an event scheduled. The free time summary calendar may be viewed in day, week, and month view formats.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially.

Abstract: A method of assembling a panel sealing apparatus and the panel sealing apparatus includes a panel. The panel defines an aperture and a sealing assembly. The assembly includes a first component and a second component, with the second component at least partially surrounding the first component and is secured to the first component to form a unit. In certain embodiments, the assembly includes a plurality of clips disconnected from each other, each configured to be attached to the panel in the aperture separately from each other and attached to the panel separately from the unit. In other embodiments, the assembly includes a band and a plurality of clips each independently attachable to and detachable from the band, each of the clips configured to be attached to the panel in the aperture separately from the unit and the clips attached to the band before placement of the clips in the aperture.

Abstract: Systems and methods are provided for supporting the use of hypertext links in documents such as word processor documents. A given word processor document is scanned for link representations to sources that are external to the word processor document. These identified link representations are then checked for validity and functionality, and the external sources are also checked for content and accessibility. In order to facilitate checking the content of the external sources, the word processor document is appended to include all or part of the content of each linked external source. The appended information is then used for subsequent content comparisons. Checking of the link representations and external sources is used to produce a current validity status for each link representations.

Abstract: A seal assembly includes a cover. A panel sealing apparatus includes the seal assembly. The apparatus includes a wall defining an orifice and the cover is disposed through the orifice. The cover includes a collar and a flange extending outwardly away from the collar. The cover defines an aperture through the collar and the flange. The assembly also includes a plate overlapping the flange and defining a hole. The collar of the cover is disposed through the hole. The assembly further includes a seal defining a passageway. The cover is disposed through the passageway. The assembly also includes a bushing defining an opening. The collar of the cover is disposed through the opening such that the bushing surrounds the collar. At least one of the plate and the bushing is configured to allow movement of the cover independently of the seal.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: This disclosure relates to methods of treatment using compound (1) or analogs thereof, and pharmaceutically acceptable salts thereof. Also disclosed are compounds of formula (10): as defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising the same. Methods of treatment, such as for cancer, are provided that comprise administering the compounds and their salts to a subject in need of such treatment.

Abstract: A truck includes an alternator having a direct current electrical power output. The truck also includes a combined inverter and charger unit having an alternating current electrical power output, a house battery and a starting battery. The combined inverter and charger unit is configured to charge the house battery and the starting battery. The truck further includes a day cab forming an interior space and a climate control unit for conditioning the interior space of the day cab. The climate control unit is adapted to be powered by an alternating current electrical source. The climate control unit is powered by the alternator through the combined inverter and charger unit when an engine of the truck engine is running, and is powered by the house battery or the starting through the combined inverter and charger unit when the engine is not running.

Abstract: A processing apparatus may include a plasma chamber to house a plasma; and an extraction assembly disposed along a side of the plasma chamber. The extraction assembly may be configured to direct ions from the plasma to a substrate, wherein the ions generate etched species comprising material that is etched from the substrate; and wherein the extraction assembly comprises at least one component having a recess that faces the substrate and is configured to intercept and retain the etched species.

Abstract: A coupling assembly includes a panel and a clip. The panel has a panel hole, and the clip is partly inserted through the panel hole. The clip is a one-way clip because, once it is partly inserted through the panel hole, it cannot be decoupled from the panel. In an embodiment, the clip includes a clip base and a plurality of retainers coupled along the clip base. Once the coupling assembly is fully assembled, the retainers extend through the panel hole. Each retainer includes a frame coupled to the clip base and an overhang rotatably coupled to the frame. Each retainer also includes a restrictor coupled to the overhang. The restrictor can rotate relative to the frame between a first restrictor position and a second restrictor position. In the second restrictor position, the restrictor inhibits the clip from decoupling from the panel.

Abstract: A method of assembling a panel sealing apparatus and the panel sealing apparatus includes a panel. The panel defines an aperture and a sealing assembly. The assembly includes a first component and a second component, with the second component at least partially surrounding the first component and is secured to the first component to form a unit. In certain embodiments, the assembly includes a plurality of clips disconnected from each other, each configured to be attached to the panel in the aperture separately from each other and attached to the panel separately from the unit. In other embodiments, the assembly includes a band and a plurality of clips each independently attachable to and detachable from the band, each of the clips configured to be attached to the panel in the aperture separately from the unit and the clips attached to the band before placement of the clips in the aperture.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.

Abstract: Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain cancer in a subject in need thereof.