Abstract: The invention provides methods for selective targeting of live cells, which have undergone or are undergoing radiation or chemotherapy, at a site of interest with a cell-penetrating polypeptide. In one embodiment of the invention, the method comprises contacting the live cells with a cell-penetrating polypeptide comprising cell-penetrating determinants so that the cell-penetrating polypeptide binds extracellular DNA near or around the live cells so as to form a complex or association therewith such that the complex or associated polypeptide-DNA so bound bind the live cells and penetrates the live cells thereby selectively targeting live cells at a site of interest with a cell-penetrating polypeptide.

Abstract: Embodiments of thermoformed monolayer or multilayer films are provided, wherein the thermoformed monolayer multilayer films comprise a first composition comprising at least one ethylene-based polymer, wherein the first composition comprises a Molecular Weighted Comonomer Distribution Index (MWCDI) value greater than 0.9, and a melt index ratio (I10/I2) that meets the following equation: I10/I2?7.0?1.2×log (I2).

Abstract: A one-piece, machined manifold for connecting air supply cylinders with a first stage regulator and recharge port has at least one bottle port configured to removably receive a bottle of pressurized air, a first stage regulator chamber, a quick disconnect fitting port, an air channel in fluid communication with the at least one bottle port and the first stage regulator chamber, and an outlet channel in fluid communication with the first stage regulator chamber.

Abstract: Embodiments described herein provide a network system to enable content playback on multiple devices. An electronic device can receive information associated with media playback request and resolve a media item and intended playback device for the media request based on a set of available media items and player devices. The device can then transmit, via the data interface, a request to play the media item at the player device via a secure device to device communication system.

Abstract: Implantable medical devices including interconnections having strain-relief structure. The interconnections can take the form of flexible circuits. Strain relief gaps and shapes are integrated in the interconnections to relieve forces in each of three dimensions. In some examples, the region of an interconnection which couples with a component of the implantable medical device is separated by a strain relief gap from a connection to a second component and/or a location where the flex bends around a corner.

Abstract: An acoustic transducer system for projecting and sensing acoustic waves or sound in fluid is disclosed in accordance with the present disclosure and figures herein. The system includes a transducer array of a plurality of channels, each channel having an inlet and an outlet, and a reservoir containing a liquid solution. A first electrode is disposed proximate to the inlet and a second electrode is disposed proximate to the outlet. A voltage source, connected to the first and second electrodes, is configured to apply voltage across a length of the array of the channels to generate an electric field parallel to each channel. The electric field causes an electroosmotic flow of ions from the reservoir to the outlet, producing a plurality of acoustic waves or sound at the outlet. A method for projecting and sensing acoustic waves or sound in fluid using the acoustic transducer system is also disclosed herein.

Abstract: Systems, devices, methods, and computer-readable media for. A method can include receiving, from a laser scan device of a tolling station, a time series of distance measurements, determining, based on the time series of distance measurements, height measurements indicating a height of a vehicle from a surface of a road. generating, based on the height measurements, an image of the height measurements, and classifying, using the image as input to a convolutional neural network (CNN), the vehicle.

Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.

Abstract: Embodiments disclosed herein related to superalloy compositions and applications using the same. The superalloy compositions disclosed herein including at least one ternary intermetallic compound having a general chemical composition of AZ[BXCY]. Base element A is selected from the group consisting of cobalt, iron, and nickel; and element B and element C are independently selected from different members of a group consisting 40 elements of the periodic table. Base element A, element B, and element C are each different elements. Z is about 2.1 to about 3.9. X and Y are about 0.1 to about 1.9. Additionally, the at least one ternary intermetallic compound of each of the superalloy compositions exhibits the face-centered cubic structure L12. The at least one ternary intermetallic compound of each of the ternary superalloy compositions may exhibit a theoretical formation enthalpy and a decomposition energy less than Co3[Al, W].

Abstract: An integrated manifold system is disclosed that combines in a single, compact, unitary assembly a one-piece, machined manifold for connecting air supply cylinders with a first stage regulator and recharge port. The manifold body has at least one bottle port configured to removably receive a bottle of pressurized air, a first stage regulator chamber, a quick disconnect fitting port, an air channel in fluid communication with the at least one bottle port and the first stage regulator chamber, and an outlet channel in fluid communication with the first stage regulator chamber.

Abstract: Disclosed is a friction ring including a body and a contact member. The body is configured to couple the friction ring to at least one of a faucet assembly or a faucet valve assembly. The contact member is disposed on the body. The contact member is configured to slidably engage with a valve stem of the faucet valve assembly. The contact member is further configured to press against the valve stem to increase a frictional force between the contact member and the valve stem over a full range of movement of the valve stem.

Abstract: The present disclosure provides resins that can be used as a tie layer in a multilayer structure and to multilayer structures comprising one or more tie layers formed from such resins. In one aspect, a resin for use as a tie layer in a multilayer structure comprises a first composition, wherein the first composition comprises at least one ethylene-based polymer and wherein the first composition comprises a MWCDI value greater than 0.9, and a melt index ratio (I10/I2) that meets the following equation: I10/I2 ? 7.0?1.2×log (I2), wherein the first composition comprises 1 to 99 weight percent of the resin; and a maleic anhydride grafted polyethylene comprising a maleic anhydride grafted high density polyethylene, a maleic anhydride grafted linear low density polyethylene, a maleic anhydride grafted polyethylene elastomer, or a combination thereof, wherein the maleic anhydride grafted polyethylene comprises 1 to 99 weight percent of the resin.

Abstract: Embodiments are directed to a tie layer composition comprising functionalized polyethylene, styrene block copolymer, base polyethylene, and antioxidant co-stabilizers, wherein the antioxidant co-stabilizers comprise at least one oxygen scavenger, at least one peroxy free radical scavenger, and at least one alkyl free radical scavenger. Further embodiments are directed to multilayer films or sheets which include the tie layer composition.

Abstract: Embodiments described herein provide a network system to enable content playback on multiple devices. An electronic device can receive information associated with media playback request and resolve a media item and intended playback device for the media request based on a set of available media items and player devices. The device can then transmit, via the data interface, a request to play the media item at the player device via a secure device to device communication system.

Abstract: Disclosed is a friction ring including a body and a contact member. The body is configured to couple the friction ring to at least one of a faucet assembly or a faucet valve assembly. The contact member is disposed on the body. The contact member is configured to slidably engage with a valve stem of the faucet valve assembly. The contact member is further configured to press against the valve stem to increase a frictional force between the contact member and the valve stem over a full range of movement of the valve stem.

Abstract: A method for mitigating the effects of cable wear in an active heave compensated hoisting system of an offshore vessel in a locked to bottom mode of operation is disclosed. The method comprises supporting an upper end of a string which is connected to a subsea well from a travelling block of the hoisting system, wherein the travelling block is suspended from a crown block via a cable. The method further comprises operating an active heave compensation system to control a drawworks of the hoisting system to pay in and out the cable to compensate for motion of the offshore vessel and maintain a target overpull in the string. The method further comprises adjusting a ballast system of the offshore vessel to vary the draft of the vessel, and controlling the drawworks in accordance with the variation in the draft of the vessel to cause a length of cable to slip through the hoisting system and maintain the target overpull in the string.

Abstract: The present disclosure provides a fitment. In an embodiment, the fitment includes a top portion, a base, and a channel extending through the top portion and the base for passage of a flowable material. The fitment is composed of a polymeric composition. The polymeric composition comprises: (i) from 60 weight % to 90 weight % of a propylene-based polymer having a density of 0.900 g/cc and a melt flow rate greater than 10.0 g/10 min; and (ii) from 40 weight % to 10 weight % of a propylene-based plastomer or elastomer (“PBPE”) having a density less than 0.900 g/cc, and a melt flow rate (MFR) from 5 g/10 min to 30 g/10 min. The present disclosure also provides a process for sealing multilayer films to the base of the fitment and the resultant flexible container formed from the process.

Abstract: Compositions and methods of treating autoimmune diseases by administering a subject in need thereof an effective amount of an inhibitor of the importin pathway are also provided. Typically, the autoimmune disease has one or more symptoms or pathologies dependent on or otherwise caused by nuclear penetrating antibodies, for example, nuclear penetrating autoantibodies. In specific embodiments, the autoimmune disease is scleroderma or a form of lupus, for example systemic lupus erythematosus. In preferred embodiments, the inhibitor of the importin pathway is a macrocyclic lactone such as an avermectin or a milbemycin. Compositions, formulations, and dosage forms including an effective amount of the macrocyclic lactones to reduce nuclear localization of a nuclear penetrating antibody are also provided. The compositions can be employed in the disclosed methods. Exemplary dosages ranges and dosage regimens are also provided.