Abstract: Embodiments described herein provide a network system to enable content playback on multiple devices. An electronic device can receive information associated with media playback request and resolve a media item and intended playback device for the media request based on a set of available media items and player devices. The device can then transmit, via the data interface, a request to play the media item at the player device via a secure device to device communication system.

Abstract: Disclosed is a friction ring including a body and a contact member. The body is configured to couple the friction ring to at least one of a faucet assembly or a faucet valve assembly. The contact member is disposed on the body. The contact member is configured to slidably engage with a valve stem of the faucet valve assembly. The contact member is further configured to press against the valve stem to increase a frictional force between the contact member and the valve stem over a full range of movement of the valve stem.

Abstract: A method for mitigating the effects of cable wear in an active heave compensated hoisting system of an offshore vessel in a locked to bottom mode of operation is disclosed. The method comprises supporting an upper end of a string which is connected to a subsea well from a travelling block of the hoisting system, wherein the travelling block is suspended from a crown block via a cable. The method further comprises operating an active heave compensation system to control a drawworks of the hoisting system to pay in and out the cable to compensate for motion of the offshore vessel and maintain a target overpull in the string. The method further comprises adjusting a ballast system of the offshore vessel to vary the draft of the vessel, and controlling the drawworks in accordance with the variation in the draft of the vessel to cause a length of cable to slip through the hoisting system and maintain the target overpull in the string.

Abstract: The present disclosure provides a fitment. In an embodiment, the fitment includes a top portion, a base, and a channel extending through the top portion and the base for passage of a flowable material. The fitment is composed of a polymeric composition. The polymeric composition comprises: (i) from 60 weight % to 90 weight % of a propylene-based polymer having a density of 0.900 g/cc and a melt flow rate greater than 10.0 g/10 min; and (ii) from 40 weight % to 10 weight % of a propylene-based plastomer or elastomer (“PBPE”) having a density less than 0.900 g/cc, and a melt flow rate (MFR) from 5 g/10 min to 30 g/10 min. The present disclosure also provides a process for sealing multilayer films to the base of the fitment and the resultant flexible container formed from the process.

Abstract: Compositions and methods of treating autoimmune diseases by administering a subject in need thereof an effective amount of an inhibitor of the importin pathway are also provided. Typically, the autoimmune disease has one or more symptoms or pathologies dependent on or otherwise caused by nuclear penetrating antibodies, for example, nuclear penetrating autoantibodies. In specific embodiments, the autoimmune disease is scleroderma or a form of lupus, for example systemic lupus erythematosus. In preferred embodiments, the inhibitor of the importin pathway is a macrocyclic lactone such as an avermectin or a milbemycin. Compositions, formulations, and dosage forms including an effective amount of the macrocyclic lactones to reduce nuclear localization of a nuclear penetrating antibody are also provided. The compositions can be employed in the disclosed methods. Exemplary dosages ranges and dosage regimens are also provided.

Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.

Abstract: A capacitively loaded loop antenna for an implantable medical device is disclosed comprising a feed extending from a conductive surface of an implantable housing, a radiating element having a cross section larger than the feed, and a return coupling the radiating element to a conductive surface of the implantable housing. The radiating element can have a height above the top surface of the implantable housing, creating a capacitance between the radiating element and the conductive surface of the implantable housing configured to counteract the inductance of the capacitively loaded loop antenna.

Abstract: Amino acid sequences capable of enhancing nuclear translocation are provided. Also referred to a nuclear localization signals (NLS) the sequences can be linked to or grafted into antibodies or fragments or fusion proteins thereof to enhance nuclear translocation of the antibody. Compositions and antibodies including an NLS conjugated or otherwise linked directly or indirectly to an active agent cargo are also provided. Exemplary cargo includes proteins, peptides, carbohydrates, polysaccharides, nucleic acid molecules, inorganic molecules, organic molecules, and diagnostic agents. Pharmaceutical compositions further including a pharmaceutically acceptable carrier are also provided. Methods of delivering the composition or antibody alone or with a cargo linked thereto to the nucleus of cell, methods of selecting or screening for compositions having a desired cellular activity, and methods of treating diseases and disorders are also provided.

Abstract: System and techniques for a virtual detent bezel device are described herein, a configuration that specifies a detent pattern and an output pattern corresponding to the detent pattern may be received receiving by the virtual detent bezel device. A physical portion of the virtual detent bezel device may sense a rotational action of a user interacting with a physical portion of the virtual detent bezel device. The rotational action may be compared to a present rotational position to determine a rotational change. The rotational change may be thresholded against the detent pattern to determine that a detent is crossed. A haptic feedback device may be activated in response to determining that the detent is crossed. A portion of the output pattern that corresponds to the detent that is crossed may be output by the virtual detent bezel device.

Abstract: An integrated manifold system is disclosed that combines in a single, compact, unitary assembly a one-piece, machined manifold for connecting air supply cylinders with a first stage regulator and recharge port. The manifold body has at least one bottle port configured to removably receive a bottle of pressurized air, a first stage regulator chamber, a quick disconnect fitting port, an air channel in fluid communication with the at least one bottle port and the first stage regulator chamber, and an outlet channel in fluid communication with the first stage regulator chamber.

Abstract: The present disclosure relates to a system of modular functional blocks that may be used to facilitate easy assembly of a welding head assembly in any one of a wide variety of configurations to allow for distribution of welding wire, gas, cooling fluid and other media throughout an interconnected assembly of the modular functional blocks. As such, the modular functional blocks can be mixed and matched into any desired configuration as needed depending on the welding process being undertaken. The modular functional blocks may be in the form of one or more different welding wire delivery blocks, gas delivery blocks, cooling water delivery blocks, shim plates, end plates, shield cup, cover plates, insulating plates, etc.

Abstract: The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.

Abstract: A faucet assembly includes a valve housing having a first side defining first and second openings, the second opening configured to receive a valve. The valve housing further includes a second side defining a third opening configured to receive at least one fluid inlet line and at least one fluid outlet line therethrough. The assembly further includes a cap configured to cover at least a portion of the third opening.

Abstract: Disclosed is a friction ring including a body and a contact member. The body is configured to couple the friction ring to at least one of a faucet assembly or a faucet valve assembly. The contact member is disposed on the body. The contact member is configured to slidably engage with a valve stem of the faucet valve assembly. The contact member is further configured to press against the valve stem to increase a frictional force between the contact member and the valve stem over a full range of movement of the valve stem.

Abstract: An optical system for beam pointing monitoring and compensation is provided. According to an embodiment, a beam pointing monitor and compensation system includes a surface plasmon resonance (SPR) optical element (800). The SPR optical element includes an optical element (801) that includes first (806) and second (802) surfaces. The first and second surfaces of the optical element are substantially parallel to each other. The SPR optical element further includes a first metal layer (803) provided on the second surface of the optical element, a dielectric layer (805) provided on the first metal layer, and a second metal layer (807) provided on the dielectric layer.

Abstract: Embodiments of thermoformed monolayer or multilayer films are provided, wherein the thermoformed monolayer multilayer films comprise a first composition comprising at least one ethylene-based polymer, wherein the first composition comprises a Molecular Weighted Comonomer Distribution Index (MWCDI) value greater than 0.9, and a melt index ratio (I10/I2) that meets the following equation: I10/I2?7.0-1.2×log (I2).

Abstract: Embodiments described herein provide a network system to enable content playback on multiple devices. An electronic device can receive information associated with media playback request and resolve a media item and intended playback device for the media request based on a set of available media items and player devices. The device can then transmit, via the data interface, a request to play the media item at the player device via a secure device to device communication system.

Abstract: The invention provides for a fusion protein comprising a 3E10 Fv joined to a Hsp-70, Hsp-27, Hsp-90 or GRP-78 or portion thereof, and optionally, the 3E10 Fv comprising an amino acid sequence AGIH at its amino terminus.

Abstract: Antigen binding molecules that bind to the epitope of 3E10, and methods of use thereof are provided. The antigen binding molecule can include, for example, two or more variant single chain variable fragments (scFv) of monoclonal antibody 3E10, wherein the variant scFv has one or more insertions, deletions, or substitutions relative to a corresponding 3E10 scFv, and wherein the molecule can bind, preferably specifically bind, to the epitope of 3E10. Methods of using the antigen binding molecules for treating cancer and viral infections or preventing viral infections are also provided.

Abstract: A method of fracturing a rock formation includes delivering particles to a wellbore disposed within the rock formation along a first section of the rock formation, flowing the particles into multiple gaps formed between the formation and a sealing element disposed within the wellbore at an intermediate position between the first section and a second section of the rock formation located downstream of the first section to fluidically isolate the first section from the second section, delivering treatment fluid to the wellbore along the first section of the rock formation, and reacting the treatment fluid with the rock formation along the first section to fracture the rock formation along the first section.